AutismKB 2.0

Annotation Detail for SPRED2


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Basic Information Top
Gene Symbol:SPRED2 ( FLJ21897,FLJ31917,MGC163164,Spred-2 )
Gene Full Name: sprouty-related, EVH1 domain containing 2
Band: 2p14
Quick LinksEntrez ID:200734; OMIM: 609292; Uniprot ID:SPRE2_HUMAN; ENSEMBL ID: ENSG00000198369; HGNC ID: 17722
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
228Phosphotyrosine (Probable).
231Phosphotyrosine (Probable).
Location(AA) Modifications Resource
Location(AA) Modification Resource
12Phosphotyrosine(Jak)HMM predict
22Phosphothreonine(PKC)HMM predict
85N-linkedHMM predict
127O-linkedHMM predict
129O-linkedHMM predict
149O-linkedHMM predict
151O-linkedHMM predict
153Phosphoserine(IKK)HMM predict
154N-linkedHMM predict
155Phosphoserine(CDK)HMM predict
155Phosphoserine(CDC2)HMM predict
156Phosphoserine(CK1)HMM predict
156Phosphoserine(ATM)HMM predict
167O-linkedHMM predict
168O-linkedHMM predict
168Phosphoserine(CDK)HMM predict
168Phosphoserine(CDC2)HMM predict
192SulfotyrosineHMM predict
249Phosphoserine(CK1)HMM predict
251Phosphotyrosine(EGFR)HMM predict
264Phosphotyrosine(Syk)HMM predict
266SulfotyrosineHMM predict
351Phosphotyrosine(INSR)HMM predict
361SulfotyrosineHMM predict
390S-palmitoylHMM predict
401TyrosineHMM predict
404GlycineHMM predict
409S-palmitoylHMM predict
410S-palmitoylHMM predict
412GlycineHMM predict
413LysineHMM predict
415LysineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_181784
  • Location:chr2 65391489-65512813
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65512661 65512980 319 7
Rb SenescentGSE19898 65513065 65513583 518 511
hScc1 BcellGSE12603 65513068 65513546 478 494
p130 shRbQuiescentGSE19898 65513105 65513667 562 573
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 65373166 65373372 206 18221
CTCF G2GSE9613 65381971 65382295 324 9357
CTCF G2GSE9613 65388760 65388934 174 2643
ER MCF7GSE19013 65380610 65381477 867 10446
Fos K562GSE19551 65379879 65380390 511 11355
Oct1 HelaGSE14283 65385345 65385374 29 6130
Rb shRbQuiescentGSE19898 65381656 65381872 216 9726
TFAP2C MCF7GSE21234 65380717 65381172 455 10545
TFAP2C MCF7GSE21234 65390083 65391005 922 946
hScc1 BcellGSE12603 65381739 65382333 594 9454
p130 SenescentGSE19898 65380818 65381392 574 10385
p130 shRbSenescentGSE19898 65381545 65381825 280 9805
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 65496861 65499238 2377 0
CTCF G2GSE9613 65412366 65412514 148 0
CTCF G2GSE9613 65431166 65431877 711 0
CTCF G2GSE9613 65458300 65458806 506 0
CTCF G2GSE9613 65463510 65463748 238 0
CTCF G2GSE9613 65493905 65494150 245 0
CTCF G2GSE9613 65511326 65511904 578 0
FOXA1 MCF7GSE15244 65453376 65454852 1476 0
FOXA1 MCF7GSE15244 65458263 65458806 543 0
FOXA1 MCF7GSE15244 65476853 65477475 622 0
FOXA1 MCF7GSE15244 65491746 65492443 697 0
Fos K562GSE19551 65447028 65447836 808 0
FoxA1 MCF7MACSdata 65400545 65400776 231 0
FoxA1 MCF7MACSdata 65453920 65454308 388 0
H3ac HepG2E 65509973 65511187 1214 0
NFkBII GM10847GSE19485 65470523 65471601 1078 0
NFkBII GM12878GSE19485 65461773 65463456 1683 0
NFkBII GM12878GSE19485 65468384 65472280 3896 0
NFkBII GM12892GSE19485 65461773 65464210 2437 0
NFkBII GM12892GSE19485 65468555 65471632 3077 0
NFkBII GM18526GSE19485 65470114 65471583 1469 0
Oct4 hESGSE21916 65437892 65438454 562 0
Oct4 hESGSE21916 65484118 65484637 519 0
P300 T30-glioblastomaGSE21026 65439647 65440708 1061 0
P300 T30-glioblastomaGSE21026 65446953 65448926 1973 0
P300 T30-glioblastomaGSE21026 65457964 65458913 949 0
RARA MCF7GSE15244 65400586 65401336 750 0
Rb GrowingGSE19898 65511586 65511715 129 0
Rb SenescentGSE19898 65440091 65440298 207 0
TAF k562GSE8489 65495398 65495571 173 0
TAF k562GSE8489 65509066 65510522 1456 0
TFAP2C MCF7GSE21234 65395422 65396085 663 0
TFAP2C MCF7GSE21234 65435372 65435907 535 0
TFAP2C MCF7GSE21234 65448126 65448575 449 0
TFAP2C MCF7GSE21234 65457993 65458911 918 0
TFAP2C MCF7GSE21234 65468640 65469231 591 0
TFAP2C MCF7GSE21234 65511051 65511474 423 0
USF1 HepG2E 65444329 65445219 890 0
VDR GM10855-stimGSE22484 65510911 65513991 3080 0
hScc1 BcellGSE12603 65463510 65463783 273 0
hScc1 BcellGSE12603 65510667 65512661 1994 0
hScc1 CdLSGSE12603 65463510 65463783 273 0
p63 keratinocytesGSE17611 65396681 65397544 863 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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