AutismKB 2.0

Annotation Detail for MARK2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:MARK2 ( EMK-1,EMK1,MGC99619,PAR-1,Par1b )
Gene Full Name: MAP/microtubule affinity-regulating kinase 2
Band: 11q13.1
Quick LinksEntrez ID:2011; OMIM: 600526; Uniprot ID:MARK2_HUMAN; ENSEMBL ID: ENSG00000072518; HGNC ID: 3332
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
29Phosphoserine.
40Phosphoserine.
42Phosphothreonine.
43Phosphoserine.
197Phosphoserine.
208Phosphothreonine.
212Phosphoserine (By similarity).
365Phosphoserine.
390Phosphoserine.
409Phosphoserine.
419Phosphothreonine.
420Phosphoserine.
422Phosphoserine.
423Phosphotyrosine.
456Phosphoserine.
469Phosphothreonine.
471Phosphoserine.
479Phosphoserine.
483Phosphoserine.
486Phosphoserine.
493Phosphoserine.
533Phosphoserine.
569Phosphoserine.
571Phosphoserine.
576Phosphoserine.
595Phosphoserine (By similarity).
596Phosphothreonine; by PKC/PRKCZ.
619Phosphoserine.
621Phosphoserine.
631Phosphoserine.
667Phosphothreonine.
722Phosphoserine.
Location(AA) Modifications Resource
40Phosphoserine.Swiss-Prot 53.0
208Phosphothreonine.Swiss-Prot 53.0
208Phosphothreonine (LKB1)Phospho.ELM 6.0
212Phosphoserine (By similarity).Swiss-Prot 53.0
456Phosphoserine.Swiss-Prot 53.0
456PhosphoserinePhospho.ELM 6.0
469Phosphothreonine.Swiss-Prot 53.0
479Phosphoserine.Swiss-Prot 53.0
486PhosphoserinePhospho.ELM 6.0
486Phosphoserine.Swiss-Prot 53.0
569Phosphoserine.Swiss-Prot 53.0
571Phosphoserine.Swiss-Prot 53.0
596Phosphothreonine (by PKC/PRKCZ).Swiss-Prot 53.0
596Phosphothreonine (PKC alpha)Phospho.ELM 6.0
619Phosphoserine.Swiss-Prot 53.0
631Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
6Phosphothreonine(CDK)HMM predict
6Phosphothreonine(CDC2)HMM predict
6Phosphothreonine(MAPK)HMM predict
30Phosphoserine(IKK)HMM predict
40Phosphoserine(PKG)HMM predict
90N-linkedHMM predict
126Phosphotyrosine(INSR)HMM predict
208PhosphothreonineHMM predict
215Phosphotyrosine(Syk)HMM predict
215Phosphotyrosine(Abl)HMM predict
226Phosphotyrosine(INSR)HMM predict
288N-linkedHMM predict
294Phosphothreonine(PKC)HMM predict
351Phosphotyrosine(EGFR)HMM predict
385N-linkedHMM predict
387O-linkedHMM predict
390Phosphoserine(ATM)HMM predict
390Phosphoserine(CDK)HMM predict
390Phosphoserine(CDC2)HMM predict
398Phosphoserine(IKK)HMM predict
409Phosphoserine(PKA)HMM predict
420O-linkedHMM predict
424Phosphoserine(CK1)HMM predict
448Phosphoserine(PKG)HMM predict
456Phosphoserine(CDC2)HMM predict
466Phosphothreonine(PKC)HMM predict
466Phosphothreonine(PKA)HMM predict
467Phosphothreonine(MAPK)HMM predict
469Phosphothreonine(MAPK)HMM predict
469Phosphothreonine(CDK)HMM predict
469O-linkedHMM predict
474Phosphoserine(IKK)HMM predict
477Phosphoserine(CK1)HMM predict
481N-linkedHMM predict
485N-linkedHMM predict
486Phosphoserine(MAPK)HMM predict
514O-linkedHMM predict
517O-linkedHMM predict
519O-linkedHMM predict
559O-linkedHMM predict
569Phosphoserine(MAPK)HMM predict
574N-linkedHMM predict
576O-linkedHMM predict
592Phosphoserine(PKB)HMM predict
619Phosphoserine(CDC2)HMM predict
619Phosphoserine(CDK)HMM predict
619Phosphoserine(MAPK)HMM predict
628MethylarginineHMM predict
631Phosphoserine(PKB)HMM predict
639Phosphothreonine(PKC)HMM predict
667Phosphothreonine(PKC)HMM predict
782IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001039469
  • Location:chr11 63419206-63433620
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 63430746 63430923 177 0
CTCF CD4SISSRdata 63430746 63430923 177 0
NRSF pAbJurkat 63426275 63426783 508 0
hScc1 BcellGSE12603 63427703 63428169 466 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 20422465
hsa-miR-1 hsa-mir-1-1 20 20422465
hsa-miR-181c hsa-mir-181c 19 20422465
hsa-miR-181c* hsa-mir-181c 19 20422465
hsa-miR-26a hsa-mir-26a-1 3 20422465
hsa-miR-26a hsa-mir-26a-2 12 20422465
hsa-miR-30d hsa-mir-30d 8 20422465
hsa-miR-30d* hsa-mir-30d 8 20422465
hsa-miR-376b hsa-mir-376b 0 20422465
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
4640 mRNA MARK2 chr11 63412650 63433628 664 EST chr11 63432921 63433639Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved