AutismKB 2.0

Annotation Detail for EN2


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Basic Information Top
Gene Symbol:EN2 ( - )
Gene Full Name: engrailed homeobox 2
Band: 7q36.3
Quick LinksEntrez ID:2020; OMIM: 131310; Uniprot ID:HME2_HUMAN; ENSEMBL ID: ENSG00000164778; HGNC ID: 3343
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
1AcetylmethionineHMM predict
24Phosphoserine(ATM)HMM predict
24O-linkedHMM predict
24Phosphoserine(CDC2)HMM predict
36Phosphoserine(CDC2)HMM predict
42Phosphothreonine(PKC)HMM predict
96MethylarginineHMM predict
150Phosphoserine(ATM)HMM predict
162Phosphoserine(CK1)HMM predict
192Phosphoserine(ATM)HMM predict
195Phosphoserine(CK1)HMM predict
197Phosphoserine(CK1)HMM predict
199Phosphoserine(CK1)HMM predict
200Phosphoserine(ATM)HMM predict
268Phosphotyrosine(Jak)HMM predict
270Phosphothreonine(PKC)HMM predict
276Phosphoserine(PKG)HMM predict
276Phosphoserine(PKA)HMM predict
282Phosphoserine(CK1)HMM predict
284N-linkedHMM predict
320N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001427
  • Location:chr7 154942175-154950259
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 154922366 154922540 174 19723
CTCF G2GSE9613 154925386 154925636 250 16665
CTCF G2GSE9613 154933669 154934058 389 8312
CTCF G2GSE9613 154935604 154936277 673 6235
CTCF G2GSE9613 154939169 154939399 230 2892
CTCF G2GSE9613 154940289 154941008 719 1527
CTCF G2GSE9613 154941452 154941777 325 561
ER MCF7GSE19013 154924380 154924890 510 17541
H3K27me3 colorectalcancer 154936496 154938612 2116 4622
H3K27me3 colorectalcancer 154941925 154942314 389 56
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 154967623 154968055 432 17580
NRSF JurkatSISSRdata 154960175 154960370 195 10013
RARA MCF7GSE15244 154967552 154968423 871 17728
hScc1 BcellGSE12603 154953101 154953487 386 3035
p63 keratinocytesGSE17611 154969268 154970138 870 19444
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 154943556 154944694 1138 0
CTCF G2GSE9613 154946094 154946483 389 0
CTCF G2GSE9613 154947146 154948003 857 0
Validated miRNA targets Top
Cis-Nats regulation Top

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  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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