AutismKB 2.0

Annotation Detail for EP300


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Basic Information Top
Gene Symbol:EP300 ( KAT3B,p300 )
Gene Full Name: E1A binding protein p300
Band: 22q13.2
Quick LinksEntrez ID:2033; OMIM: 602700; Uniprot ID:EP300_HUMAN; ENSEMBL ID: ENSG00000100393; HGNC ID: 3373
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
17Nuclear localization signal (Potential).
285Phosphoserine.
580Omega-N-methylated arginine; by CARM1.
604Omega-N-methylated arginine; by CARM1.
636N6-acetyllysine.
885Phosphothreonine.
887Phosphothreonine.
977N6-acetyllysine.
981N6-acetyllysine.
1038Phosphoserine.
1103N6-acetyllysine.
1336N6-acetyllysine; by autocatalysis.
1473N6-acetyllysine; by autocatalysis.
1499N6-acetyllysine; by autocatalysis.
1542N6-acetyllysine; by autocatalysis.
1546N6-acetyllysine; by autocatalysis.
1549N6-acetyllysine; by autocatalysis.
1550N6-acetyllysine; by autocatalysis.
1551N6-acetyllysine; by autocatalysis.
1554N6-acetyllysine; by autocatalysis.
1555N6-acetyllysine; by autocatalysis.
1558N6-acetyllysine; by autocatalysis.
1560N6-acetyllysine; by autocatalysis.
1568N6-acetyllysine; by autocatalysis.
1569N6-acetyllysine; by autocatalysis.
1583N6-acetyllysine.
1590N6-acetyllysine.
1637N6-acetyllysine; by autocatalysis.
1674N6-acetyllysine.
1734Phosphoserine.
1857Phosphothreonine.
1859Phosphothreonine.
2142Asymmetric dimethylarginine; by CARM1;
2142Citrulline; by PADI4; alternate.
Location(AA) Modifications Resource
24Phosphoserine (CaM-KIV)Phospho.ELM 6.0
89Phosphoserine (PKC alpha;PK)Phospho.ELM 6.0
580Omega-N-methylated arginine.Swiss-Prot 53.0
604Omega-N-methylated arginine.Swiss-Prot 53.0
1554N6-acetyllysine.Swiss-Prot 53.0
1555N6-acetyllysine.Swiss-Prot 53.0
1558N6-acetyllysine.Swiss-Prot 53.0
1560N6-acetyllysine.Swiss-Prot 53.0
1834Phosphoserine (PKB
2142Asymmetric dimethylarginine; alternate.Swiss-Prot 53.0
2142Citrulline; alternate.Swiss-Prot 53.0
Location(AA) Modification Resource
20Phosphoserine(CDC2)HMM predict
24O-linkedHMM predict
49N-linkedHMM predict
89PhosphoserineHMM predict
106Phosphoserine(ATM)HMM predict
200MethylarginineHMM predict
253Phosphotyrosine(INSR)HMM predict
253Phosphotyrosine(Abl)HMM predict
255O-linkedHMM predict
255Phosphoserine(CDC2)HMM predict
285Phosphoserine(CDC2)HMM predict
317Phosphothreonine(MAPK)HMM predict
405N-linkedHMM predict
439N-linkedHMM predict
452N-linkedHMM predict
499Phosphoserine(CDC2)HMM predict
524Phosphothreonine(MAPK)HMM predict
539Phosphoserine(ATM)HMM predict
547N-linkedHMM predict
552O-linkedHMM predict
620Phosphotyrosine(EGFR)HMM predict
620Phosphotyrosine(INSR)HMM predict
629SulfotyrosineHMM predict
719Phosphoserine(IKK)HMM predict
730Phosphothreonine(PKA)HMM predict
730Phosphothreonine(MAPK)HMM predict
730PhosphothreonineHMM predict
776N-linkedHMM predict
779N-linkedHMM predict
786O-linkedHMM predict
792Phosphoserine(ATM)HMM predict
792Phosphoserine(IKK)HMM predict
812Phosphoserine(ATM)HMM predict
815O-linkedHMM predict
831O-linkedHMM predict
833O-linkedHMM predict
833Phosphoserine(CDC2)HMM predict
833Phosphoserine(MAPK)HMM predict
833Phosphoserine(CDK)HMM predict
833Phosphoserine(ATM)HMM predict
833PhosphoserineHMM predict
837O-linkedHMM predict
839Phosphothreonine(MAPK)HMM predict
841Phosphothreonine(MAPK)HMM predict
845Phosphothreonine(MAPK)HMM predict
848O-linkedHMM predict
857O-linkedHMM predict
857O-linkedHMM predict
865O-linkedHMM predict
887O-linkedHMM predict
887Phosphothreonine(MAPK)HMM predict
891O-linkedHMM predict
900O-linkedHMM predict
916Phosphoserine(ATM)HMM predict
916Phosphoserine(IKK)HMM predict
919O-linkedHMM predict
919Phosphoserine(IKK)HMM predict
920O-linkedHMM predict
923O-linkedHMM predict
923Phosphoserine(IKK)HMM predict
938Phosphothreonine(MAPK)HMM predict
938Phosphothreonine(CDK)HMM predict
952Phosphoserine(IKK)HMM predict
956O-linkedHMM predict
956O-linkedHMM predict
956Phosphoserine(IKK)HMM predict
958Phosphoserine(CK1)HMM predict
973Phosphoserine(ATM)HMM predict
1009PhosphoserineHMM predict
1010Phosphothreonine(CK2)HMM predict
1031O-linkedHMM predict
1031Phosphoserine(IKK)HMM predict
1033O-linkedHMM predict
1035O-linkedHMM predict
1037Phosphoserine(IKK)HMM predict
1038O-linkedHMM predict
1163S-palmitoylHMM predict
1164S-palmitoylHMM predict
1220Phosphoserine(ATM)HMM predict
1220Phosphoserine(IKK)HMM predict
1236N-linkedHMM predict
1275S-palmitoylHMM predict
1491Phosphothreonine(PKC)HMM predict
1532N-linkedHMM predict
1534Phosphoserine(CK1)HMM predict
1535N-linkedHMM predict
1559N-linkedHMM predict
1585Phosphotyrosine(INSR)HMM predict
1726Phosphoserine(IKK)HMM predict
1734Phosphoserine(PKG)HMM predict
1752N-linkedHMM predict
1790S-palmitoylHMM predict
1834Phosphoserine(PKA)HMM predict
1834Phosphoserine(CAMK2)HMM predict
1849O-linkedHMM predict
1849Phosphoserine(CDC2)HMM predict
1849Phosphoserine(MAPK)HMM predict
1849Phosphoserine(CDK)HMM predict
1851O-linkedHMM predict
1854O-linkedHMM predict
1857O-linkedHMM predict
1864O-linkedHMM predict
1868Phosphothreonine(MAPK)HMM predict
1868Phosphothreonine(CDK)HMM predict
1872O-linkedHMM predict
1872O-linkedHMM predict
1872O-linkedHMM predict
1873O-linkedHMM predict
1873O-linkedHMM predict
1873Phosphoserine(ATM)HMM predict
1873Phosphoserine(IKK)HMM predict
1878O-linkedHMM predict
1878Phosphothreonine(MAPK)HMM predict
1878PhosphothreonineHMM predict
1897O-linkedHMM predict
1897Phosphoserine(ATM)HMM predict
1906O-linkedHMM predict
1906Phosphothreonine(MAPK)HMM predict
1909Phosphothreonine(MAPK)HMM predict
1909Phosphothreonine(CDK)HMM predict
1909PhosphothreonineHMM predict
2039Phosphoserine(CDC2)HMM predict
2057Phosphothreonine(PKC)HMM predict
2060Phosphoserine(CDC2)HMM predict
2060Phosphoserine(IKK)HMM predict
2062Phosphoserine(CK1)HMM predict
2062PhosphoserineHMM predict
2063Phosphoserine(CDC2)HMM predict
2063Phosphoserine(MAPK)HMM predict
2063Phosphoserine(IKK)HMM predict
2271Phosphoserine(CDC2)HMM predict
2291Phosphoserine(CDK)HMM predict
2309Phosphoserine(CDC2)HMM predict
2309Phosphoserine(CDK)HMM predict
2315O-linkedHMM predict
2315Phosphoserine(CDC2)HMM predict
2315Phosphoserine(MAPK)HMM predict
2320Phosphoserine(ATM)HMM predict
2320Phosphoserine(IKK)HMM predict
2326Phosphoserine(CDC2)HMM predict
2326Phosphoserine(CDK)HMM predict
2328O-linkedHMM predict
2345O-linkedHMM predict
2346Phosphoserine(CDC2)HMM predict
2371Phosphoserine(IKK)HMM predict
2374Phosphoserine(ATM)HMM predict
2378Phosphoserine(IKK)HMM predict
2404Phosphoserine(IKK)HMM predict
2405N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001429
  • Location:chr22 39818552-39906023
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 39817797 39817946 149 681
PHF8 293TGSE20725 39816997 39819035 2038 537
PHF8 HeLaGSE20725 39816747 39819532 2785 413
PHF8 Hs68minusFBSGSE20725 39816879 39817629 750 1299
Pol2 GM12878GSE19551 39817043 39818875 1832 594
RARG MCF7GSE15244 39800172 39800798 626 18068
Rb GrowingGSE19898 39817055 39817255 200 1398
hScc1 BcellGSE12603 39816998 39817977 979 1065
hScc1 CdLSGSE12603 39816788 39817725 937 1296
p130 QuiescentGSE19898 39817158 39817392 234 1278
p130 SenescentGSE19898 39817110 39817429 319 1283
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog hESGSE18292 39914283 39914521 238 8379
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 39819055 39820113 1058 0
H3ac HepG2E 39819027 39820870 1843 0
NRSF JurkatGSE13047 39873713 39874127 414 0
NRSF JurkatSISSRdata 39873745 39874127 382 0
NRSF mAbJurkat 39872494 39872946 452 0
NRSF mAbJurkat 39873704 39875552 1848 0
NRSF-mono JurkatQuESTdata 39873738 39874126 388 0
NRSF-poly JurkatQuESTdata 39873721 39874121 400 0
Rb SenescentGSE19898 39818415 39818691 276 0
TAF k562GSE8489 39819089 39820870 1781 0
TAF k562GSE8489 39822187 39822519 332 0
hScc1 BcellGSE12603 39818706 39819124 418 0
hScc1 BcellGSE12603 39903076 39903552 476 0
hScc1 BcellGSE12603 39904018 39904647 629 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-132 hsa-mir-132 17 21118894
hsa-miR-132 hsa-mir-132 17 20418869
hsa-miR-132* hsa-mir-132 17 21118894
hsa-miR-132* hsa-mir-132 17 20418869
hsa-miR-182 hsa-mir-182 7 19569050
hsa-miR-182* hsa-mir-182 7 19569050
hsa-miR-194 hsa-mir-194-1 1 19569050
hsa-miR-194 hsa-mir-194-2 11 19569050
hsa-miR-200b hsa-mir-200b 1 19569050
hsa-miR-200b* hsa-mir-200b 1 19569050
hsa-miR-200c hsa-mir-200c 12 19569050
hsa-miR-200c* hsa-mir-200c 12 19569050
hsa-miR-26b hsa-mir-26b 2 19569050
hsa-miR-26b* hsa-mir-26b 2 19569050
hsa-miR-30e hsa-mir-30e 1 20579744
hsa-miR-30e* hsa-mir-30e 1 20579744
hsa-miR-372 hsa-mir-372 19 20423907
hsa-miR-374a hsa-mir-374a X 19569050
hsa-miR-374a* hsa-mir-374a X 19569050
hsa-miR-374b hsa-mir-374b X 19569050
hsa-miR-374b* hsa-mir-374b X 19569050
hsa-miR-429 hsa-mir-429 1 19569050
hsa-miR-548a-5p hsa-mir-548a-3 8 21057533
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
17519 mRNA EP300 chr22 39813106 39900578 60 EST chr22 39889693 39903648Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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