AutismKB 2.0

Annotation Detail for EPHA3


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:EPHA3 ( EK4,ETK,ETK1,HEK,HEK4,TYRO4 )
Gene Full Name: EPH receptor A3
Band: 3p11.1
Quick LinksEntrez ID:2042; OMIM: 179611; Uniprot ID:EPHA3_HUMAN; ENSEMBL ID: ENSG00000044524; HGNC ID: 3387
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
232N-linked (GlcNAc...) (Potential).
337N-linked (GlcNAc...) (Potential).
391N-linked (GlcNAc...) (Potential).
404N-linked (GlcNAc...) (Potential).
493N-linked (GlcNAc...) (Potential).
596Phosphotyrosine; by autocatalysis
602Phosphotyrosine; by autocatalysis
779Phosphotyrosine; by autocatalysis.
937Phosphotyrosine (By similarity).
983PDZ-binding (Potential).
Location(AA) Modifications Resource
232N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
337N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
391N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
404N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
493N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
596Phosphotyrosine (EphA3)Phospho.ELM 6.0
596Phosphotyrosine (by autocatalysis)(Potential).Swiss-Prot 53.0
602Phosphotyrosine (by autocatalysis)(Potential).Swiss-Prot 53.0
602Phosphotyrosine (EphA3)Phospho.ELM 6.0
779Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
779Phosphotyrosine (EphA3)Phospho.ELM 6.0
Location(AA) Modification Resource
63Phosphothreonine(CDC2)HMM predict
123SulfotyrosineHMM predict
124SulfotyrosineHMM predict
151Phosphoserine(IKK)HMM predict
222Phosphoserine(IKK)HMM predict
229Phosphoserine(IKK)HMM predict
232N-linkedHMM predict
233N-linkedHMM predict
328O-linkedHMM predict
328Phosphoserine(CDC2)HMM predict
337N-linkedHMM predict
366S-palmitoylHMM predict
391N-linkedHMM predict
404N-linkedHMM predict
420Phosphoserine(CDC2)HMM predict
438Phosphoserine(MAPK)HMM predict
454Phosphoserine(CK1)HMM predict
475Phosphotyrosine(Syk)HMM predict
493N-linkedHMM predict
497Phosphoserine(CDC2)HMM predict
532Phosphoserine(IKK)HMM predict
534Phosphoserine(CK1)HMM predict
536Phosphoserine(CK2)HMM predict
536Phosphoserine(ATM)HMM predict
540Phosphoserine(ATM)HMM predict
602Phosphotyrosine(Syk)HMM predict
602Phosphotyrosine(SRC)HMM predict
602Phosphotyrosine(INSR)HMM predict
602PhosphotyrosineHMM predict
644PhosphoserineHMM predict
690Phosphothreonine(PKC)HMM predict
704N-linkedHMM predict
742Phosphotyrosine(Jak)HMM predict
802Phosphothreonine(PKA)HMM predict
803Phosphoserine(PKA)HMM predict
938Phosphoserine(IKK)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005233
  • Location:chr3 89239363-89613971
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 89230862 89231196 334 8335
Oct1 HelaGSE14283 89237661 89237717 56 1675
hScc1 BcellGSE12603 89230756 89231111 355 8430
hScc1 CdLSGSE12603 89230542 89231267 725 8459
hScc1 G2GSE9613 89230827 89231267 440 8317
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 89545349 89545387 38 0
Oct1 H2O2-HelaGSE14283 89549240 89549271 31 0
Oct1 H2O2-HelaGSE14283 89551079 89551108 29 0
Oct1 H2O2-HelaGSE14283 89572478 89572506 28 0
Oct1 H2O2-HelaGSE14283 89580927 89580953 26 0
Oct1 HelaGSE14283 89549241 89549271 30 0
Oct1 HelaGSE14283 89580909 89580956 47 0
RNAII Tamoxifen-MCF7GSE14664 89587685 89587776 91 0
RNAII Tamoxifen-MCF7GSE14664 89588581 89588675 94 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved