AutismKB 2.0

Annotation Detail for EPHB2


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Basic Information Top
Gene Symbol:EPHB2 ( CAPB,DRT,EK5,EPHT3,ERK,Hek5,MGC87492,PCBC,Tyro5 )
Gene Full Name: EPH receptor B2
Band: 1p36.12
Quick LinksEntrez ID:2048; OMIM: 600997; Uniprot ID:EPHB2_HUMAN; ENSEMBL ID: ENSG00000133216; HGNC ID: 3393
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
148Phosphoserine.
265N-linked (GlcNAc...) (Potential).
336N-linked (GlcNAc...) (Potential).
428N-linked (GlcNAc...) (Potential).
482N-linked (GlcNAc...) (Potential).
596Phosphotyrosine.
602Phosphotyrosine.
775Phosphothreonine.
776Phosphoserine.
779Phosphothreonine.
780Phosphotyrosine.
897Phosphoserine.
983Phosphoserine.
986PDZ-binding (in isoform 2) (Potential).
Location(AA) Modifications Resource
265N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
336N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
428N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
482N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
596Phosphotyrosine (by autocatalysis)(Potential).Swiss-Prot 53.0
602Phosphotyrosine (by autocatalysis)(Potential).Swiss-Prot 53.0
775Phosphothreonine.Swiss-Prot 53.0
780Phosphotyrosine (by autocatalysis)(Potential).Swiss-Prot 53.0
930Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
99Phosphoserine(IKK)HMM predict
99Phosphoserine(CK1)HMM predict
102Phosphoserine(CK1)HMM predict
106Phosphoserine(IKK)HMM predict
114SulfotyrosineHMM predict
115SulfotyrosineHMM predict
122O-linkedHMM predict
148Phosphoserine(CK1)HMM predict
148Phosphoserine(ATM)HMM predict
212Phosphoserine(CK2)HMM predict
212Phosphoserine(ATM)HMM predict
265N-linkedHMM predict
297Phosphoserine(IKK)HMM predict
297Phosphoserine(CAMK2)HMM predict
297O-linkedHMM predict
336N-linkedHMM predict
421Phosphoserine(CDK)HMM predict
421Phosphoserine(CDC2)HMM predict
428N-linkedHMM predict
432N-linkedHMM predict
448Phosphothreonine(PKC)HMM predict
457Phosphoserine(IKK)HMM predict
457Phosphoserine(ATM)HMM predict
473SulfotyrosineHMM predict
474Phosphotyrosine(EGFR)HMM predict
479Phosphoserine(CK1)HMM predict
482N-linkedHMM predict
490O-linkedHMM predict
512Phosphothreonine(PKC)HMM predict
575Phosphoserine(CK1)HMM predict
590Phosphothreonine(CDC2)HMM predict
602Phosphotyrosine(Syk)HMM predict
602PhosphotyrosineHMM predict
654Phosphothreonine(PKC)HMM predict
693Phosphothreonine(PKA)HMM predict
704N-linkedHMM predict
776Phosphoserine(CK1)HMM predict
779O-linkedHMM predict
804Phosphothreonine(PKA)HMM predict
805Phosphoserine(PKA)HMM predict
996Phosphothreonine(PKA)HMM predict
996Phosphothreonine(PKC)HMM predict
1027Phosphothreonine(PKA)HMM predict
1053S-farnesylHMM predict
1054GlycineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004442
  • Location:chr1 22909917-23114408
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 22903616 22903874 258 6173
CTCF CD4SISSRdata 22903616 22903874 258 6173
CTCF G2GSE9613 22894106 22894488 382 15621
CTCF G2GSE9613 22903509 22903875 366 6226
CTCF G2GSE9613 22908661 22908836 175 1169
CTCF G2GSE9613 22909677 22909935 258 112
hScc1 BcellGSE12603 22903509 22904095 586 6116
hScc1 CdLSGSE12603 22903240 22904131 891 6232
p130 SenescentGSE19898 22901892 22902178 286 7883
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 23115422 23115802 380 1204
CTCF G2GSE9613 23124289 23124494 205 9983
CTCF G2GSE9613 23129295 23129694 399 15086
Oct4 hESGSE17917 23123623 23123947 324 9377
hScc1 BcellGSE12603 23115422 23115937 515 1271
hScc1 BcellGSE12603 23124171 23124494 323 9924
hScc1 BcellGSE12603 23129331 23129731 400 15123
hScc1 CdLSGSE12603 23129295 23129731 436 15105
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 22949125 22949859 734 0
CTCF JurkatGSE12889 23088428 23088565 137 0
CTCF G2GSE9613 22910404 22910714 310 0
CTCF G2GSE9613 22912146 22912908 762 0
CTCF G2GSE9613 22921923 22922217 294 0
CTCF G2GSE9613 22923710 22923961 251 0
CTCF G2GSE9613 22926382 22926612 230 0
CTCF G2GSE9613 22929709 22929938 229 0
CTCF G2GSE9613 22930946 22931122 176 0
CTCF G2GSE9613 22956357 22956473 116 0
CTCF G2GSE9613 22961178 22961464 286 0
CTCF G2GSE9613 22982368 22982582 214 0
CTCF G2GSE9613 23004777 23005030 253 0
CTCF G2GSE9613 23021970 23022123 153 0
CTCF G2GSE9613 23026329 23026505 176 0
CTCF G2GSE9613 23052708 23053027 319 0
CTCF G2GSE9613 23053919 23054427 508 0
CTCF G2GSE9613 23055050 23055277 227 0
CTCF G2GSE9613 23059431 23060025 594 0
CTCF G2GSE9613 23061149 23061364 215 0
CTCF G2GSE9613 23062134 23062694 560 0
CTCF G2GSE9613 23069280 23069790 510 0
CTCF G2GSE9613 23088821 23089283 462 0
CTCF G2GSE9613 23109323 23109636 313 0
CTCF G2GSE9613 23113031 23113310 279 0
ER E2-MCF7GSE14664 22993733 22993776 43 0
NFkBII GM12878GSE19485 23008992 23010412 1420 0
NFkBII GM12892GSE19485 23009004 23010356 1352 0
Oct1 H2O2-HelaGSE14283 22993733 22993768 35 0
Oct1 HelaGSE14283 22979896 22979926 30 0
Oct1 HelaGSE14283 22993733 22993764 31 0
Oct1 HelaGSE14283 23091480 23091546 66 0
P300 T0-glioblastomaGSE21026 22949373 22950007 634 0
P300 T30-glioblastomaGSE21026 22938509 22939988 1479 0
P300 T30-glioblastomaGSE21026 22945697 22947206 1509 0
P300 T30-glioblastomaGSE21026 22949185 22950038 853 0
P300 T30-glioblastomaGSE21026 23030637 23031862 1225 0
RARA MCF7GSE15244 23025327 23027013 1686 0
RARG MCF7GSE15244 23025327 23026977 1650 0
Rb GrowingGSE19898 23006410 23006681 271 0
Rb GrowingGSE19898 23012305 23012493 188 0
Rb QuiescentGSE19898 22911731 22911896 165 0
Rb QuiescentGSE19898 22967003 22967212 209 0
Rb SenescentGSE19898 22910892 22911218 326 0
TFAP2C MCF7GSE21234 22950132 22950735 603 0
TFAP2C MCF7GSE21234 22956172 22956693 521 0
TFAP2C MCF7GSE21234 23049500 23050235 735 0
hScc1 BcellGSE12603 22910404 22910714 310 0
hScc1 BcellGSE12603 22930946 22931122 176 0
hScc1 BcellGSE12603 22946551 22946886 335 0
hScc1 BcellGSE12603 22960755 22961369 614 0
hScc1 BcellGSE12603 22998040 22998334 294 0
hScc1 BcellGSE12603 23003490 23003781 291 0
hScc1 BcellGSE12603 23004847 23005030 183 0
hScc1 BcellGSE12603 23026150 23026867 717 0
hScc1 BcellGSE12603 23053919 23054174 255 0
hScc1 CdLSGSE12603 22930946 22931335 389 0
hScc1 CdLSGSE12603 23060764 23061364 600 0
hScc1 CdLSGSE12603 23088243 23088783 540 0
p130 QuiescentGSE19898 23007831 23008042 211 0
p130 QuiescentGSE19898 23008051 23008183 132 0
p130 SenescentGSE19898 23007868 23008126 258 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7a hsa-let-7a-1 9 20097187
hsa-let-7a hsa-let-7a-2 11 20097187
hsa-let-7a hsa-let-7a-3 22 20097187
hsa-let-7a hsa-let-7a-1 9 19804757
hsa-let-7a hsa-let-7a-2 11 19804757
hsa-let-7a hsa-let-7a-3 22 19804757
hsa-let-7a* hsa-let-7a-1 9 19804757
hsa-let-7a* hsa-let-7a-3 22 19804757
hsa-let-7b hsa-let-7b 22 18704095
hsa-let-7b hsa-let-7b 22 19804757
hsa-let-7b* hsa-let-7b 22 18704095
hsa-let-7b* hsa-let-7b 22 19804757
hsa-let-7c hsa-let-7c 21 18704095
hsa-let-7c hsa-let-7c 21 19804757
hsa-let-7c* hsa-let-7c 21 18704095
hsa-let-7c* hsa-let-7c 21 19804757
hsa-let-7d hsa-let-7d 9 19804757
hsa-let-7d* hsa-let-7d 9 19804757
hsa-let-7e hsa-let-7e 19 19804757
hsa-let-7e* hsa-let-7e 19 19804757
hsa-let-7f hsa-let-7f-1 9 19804757
hsa-let-7f hsa-let-7f-2 X 19804757
hsa-let-7f-1* hsa-let-7f-1 9 19804757
hsa-let-7f-2* hsa-let-7f-2 X 19804757
hsa-let-7g hsa-let-7g 3 19804757
hsa-let-7g* hsa-let-7g 3 19804757
hsa-let-7i hsa-let-7i 12 19804757
hsa-let-7i* hsa-let-7i 12 19804757
hsa-miR-101 hsa-mir-101-1 1 20444294
hsa-miR-101 hsa-mir-101-2 9 20444294
hsa-miR-126 hsa-mir-126 9 20097187
hsa-miR-126 hsa-mir-126 9 18987025
hsa-miR-126* hsa-mir-126 9 20097187
hsa-miR-126* hsa-mir-126 9 18987025
hsa-miR-132 hsa-mir-132 17 19958814
hsa-miR-132* hsa-mir-132 17 19958814
hsa-miR-144 hsa-mir-144 17 18704095
hsa-miR-144* hsa-mir-144 17 18704095
hsa-miR-145 hsa-mir-145 5 20097187
hsa-miR-145* hsa-mir-145 5 20097187
hsa-miR-155 hsa-mir-155 21 19074725
hsa-miR-155 hsa-mir-155 21 18048365
hsa-miR-155* hsa-mir-155 21 19074725
hsa-miR-155* hsa-mir-155 21 18048365
hsa-miR-15b hsa-mir-15b 3 20154725
hsa-miR-15b* hsa-mir-15b 3 20154725
hsa-miR-16 hsa-mir-16-1 13 20154725
hsa-miR-16 hsa-mir-16-2 3 20154725
hsa-miR-184 hsa-mir-184 15 19074725
hsa-miR-190 hsa-mir-190 15 20457614
hsa-miR-199a-3p hsa-mir-199a-1 19 20643939
hsa-miR-199a-3p hsa-mir-199a-2 1 20643939
hsa-miR-206 hsa-mir-206 6 19074725
hsa-miR-21 hsa-mir-21 17 20832755
hsa-miR-21 hsa-mir-21 17 20489163
hsa-miR-21 hsa-mir-21 17 20154725
hsa-miR-21* hsa-mir-21 17 20832755
hsa-miR-21* hsa-mir-21 17 20489163
hsa-miR-21* hsa-mir-21 17 20154725
hsa-miR-22 hsa-mir-22 17 20214878
hsa-miR-22* hsa-mir-22 17 20214878
hsa-miR-221 hsa-mir-221 X 20299489
hsa-miR-221 hsa-mir-221 X 19438724
hsa-miR-221 hsa-mir-221 X 18704095
hsa-miR-221* hsa-mir-221 X 20299489
hsa-miR-221* hsa-mir-221 X 19438724
hsa-miR-221* hsa-mir-221 X 18704095
hsa-miR-222 hsa-mir-222 X 20299489
hsa-miR-222 hsa-mir-222 X 19438724
hsa-miR-222* hsa-mir-222 X 20299489
hsa-miR-222* hsa-mir-222 X 19438724
hsa-miR-29c hsa-mir-29c 1 20444294
hsa-miR-29c* hsa-mir-29c 1 20444294
hsa-miR-30c hsa-mir-30c-2 6 18704095
hsa-miR-30c hsa-mir-30c-1 1 18704095
hsa-miR-34a hsa-mir-34a 1 20299489
hsa-miR-34a hsa-mir-34a 1 18704095
hsa-miR-34a* hsa-mir-34a 1 20299489
hsa-miR-34a* hsa-mir-34a 1 18704095
hsa-miR-363* hsa-mir-363 X 19074725
hsa-miR-372 hsa-mir-372 19 20154725
hsa-miR-373 hsa-mir-373 19 20154725
hsa-miR-373* hsa-mir-373 19 20154725
hsa-miR-375 hsa-mir-375 2 21291493
hsa-miR-494 hsa-mir-494 14 19074725
hsa-miR-7 hsa-mir-7-1 9 20978205
hsa-miR-7 hsa-mir-7-2 15 20978205
hsa-miR-7 hsa-mir-7-3 19 20978205
hsa-miR-9 hsa-mir-9-1 1 19958814
hsa-miR-9 hsa-mir-9-2 5 19958814
hsa-miR-9 hsa-mir-9-3 15 19958814
hsa-miR-9* hsa-mir-9-1 1 19074725
hsa-miR-9* hsa-mir-9-2 5 19074725
hsa-miR-9* hsa-mir-9-3 15 19074725
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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