AutismKB 2.0

Annotation Detail for EPHB3


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Basic Information Top
Gene Symbol:EPHB3 ( ETK2,HEK2,TYRO6 )
Gene Full Name: EPH receptor B3
Band: 3q27.1
Quick LinksEntrez ID:2049; OMIM: 601839; Uniprot ID:EPHB3_HUMAN; ENSEMBL ID: ENSG00000182580; HGNC ID: 3394
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
351N-linked (GlcNAc...) (Potential).
445N-linked (GlcNAc...) (Potential).
600Phosphotyrosine.
608Phosphotyrosine.
614Phosphotyrosine.
792Phosphotyrosine.
971Phosphothreonine.
998PDZ-binding (Potential).
Location(AA) Modifications Resource
351N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
445N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
608Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
608PhosphotyrosinePhospho.ELM 6.0
614Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
614Phosphotyrosine (EphB3)Phospho.ELM 6.0
792Phosphotyrosine (by autocatalysis)(Potential).Swiss-Prot 53.0
942Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
Location(AA) Modification Resource
11O-linkedHMM predict
68Phosphotyrosine(Syk)HMM predict
87Phosphoserine(CK1)HMM predict
146Phosphoserine(ATM)HMM predict
176Phosphothreonine(PKC)HMM predict
282Phosphoserine(IKK)HMM predict
312Phosphoserine(IKK)HMM predict
312Phosphoserine(CAMK2)HMM predict
312PhosphoserineHMM predict
312Phosphoserine(PKB)HMM predict
312Phosphoserine(CDC2)HMM predict
316O-linkedHMM predict
331O-linkedHMM predict
334O-linkedHMM predict
337O-linkedHMM predict
338O-linkedHMM predict
341O-linkedHMM predict
341Phosphoserine(CDC2)HMM predict
351N-linkedHMM predict
435Phosphoserine(CDC2)HMM predict
435Phosphoserine(CDK)HMM predict
441Phosphotyrosine(Jak)HMM predict
445N-linkedHMM predict
449N-linkedHMM predict
463Phosphoserine(CK1)HMM predict
464O-linkedHMM predict
467Phosphoserine(CK1)HMM predict
472Phosphoserine(IKK)HMM predict
486SulfotyrosineHMM predict
527Phosphothreonine(PKC)HMM predict
548Phosphoserine(IKK)HMM predict
614PhosphotyrosineHMM predict
614Phosphotyrosine(Syk)HMM predict
702Phosphothreonine(PKC)HMM predict
788Phosphoserine(CK1)HMM predict
816Phosphothreonine(PKA)HMM predict
817Phosphoserine(PKA)HMM predict
839Phosphotyrosine(Syk)HMM predict
855Phosphotyrosine(EGFR)HMM predict
925O-linkedHMM predict
983IsoleucineHMM predict
991N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004443
  • Location:chr3 185762280-185782888
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 185744518 185744869 351 17587
CTCF CD4GSE12889 185761680 185762150 470 366
CTCF CD4SISSRdata 185744518 185744869 351 17587
CTCF CD4SISSRdata 185761680 185762150 470 366
CTCF G2GSE9613 185742348 185742614 266 19800
CTCF G2GSE9613 185743979 185744938 959 17822
CTCF G2GSE9613 185747643 185747918 275 14500
CTCF G2GSE9613 185750053 185750510 457 11999
CTCF G2GSE9613 185751517 185752354 837 10345
CTCF G2GSE9613 185755908 185756054 146 6300
CTCF G2GSE9613 185757700 185758032 332 4415
CTCF G2GSE9613 185758635 185758914 279 3506
CTCF G2GSE9613 185759780 185760118 338 2332
CTCF G2GSE9613 185760960 185763523 2563 39
FOXA1 MCF7GSE15244 185759245 185760365 1120 2476
FOXA1 MCF7GSE15244 185761369 185761926 557 633
Fos K562GSE19551 185761668 185762293 625 300
P300 T0-glioblastomaGSE21026 185744244 185744990 746 17664
RARA MCF7GSE15244 185750546 185750935 389 11540
RARG MCF7GSE15244 185759202 185760365 1163 2497
RARG MCF7GSE15244 185761434 185761889 455 619
hScc1 BcellGSE12603 185743943 185744872 929 17873
hScc1 BcellGSE12603 185760960 185762492 1532 555
hScc1 CdLSGSE12603 185744401 185744909 508 17626
hScc1 CdLSGSE12603 185761434 185762426 992 351
hScc1 G2GSE9613 185743943 185744938 995 17840
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 185782531 185784068 1537 411
CTCF G2GSE9613 185784735 185785172 437 2065
CTCF G2GSE9613 185788508 185788719 211 5725
CTCF G2GSE9613 185792266 185792794 528 9642
CTCF G2GSE9613 185793330 185793905 575 10729
CTCF G2GSE9613 185794154 185794584 430 11481
CTCF G2GSE9613 185796202 185796539 337 13482
CTCF G2GSE9613 185798402 185799414 1012 16020
ER MCF7GSE19013 185798284 185799055 771 15781
Nanog hESGSE18292 185796137 185796534 397 13447
TFAP2C MCF7GSE21234 185801267 185802030 763 18760
hScc1 BcellGSE12603 185784895 185785172 277 2145
hScc1 BcellGSE12603 185801540 185801737 197 18750
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 185764142 185764491 349 0
CTCF G2GSE9613 185766155 185766861 706 0
CTCF G2GSE9613 185767378 185767708 330 0
CTCF G2GSE9613 185769132 185770224 1092 0
CTCF G2GSE9613 185770979 185771199 220 0
CTCF G2GSE9613 185775472 185776424 952 0
CTCF G2GSE9613 185777338 185778902 1564 0
CTCF G2GSE9613 185779175 185780447 1272 0
CTCF G2GSE9613 185781314 185781680 366 0
FOXA1 MCF7GSE15244 185779913 185780486 573 0
FoxA1 MCF7MACSdata 185766938 185767247 309 0
RARG MCF7GSE15244 185779843 185780783 940 0
TFAP2C MCF7GSE21234 185765969 185766728 759 0
TFAP2C MCF7GSE21234 185779767 185780557 790 0
hScc1 BcellGSE12603 185769744 185770091 347 0
hScc1 BcellGSE12603 185771982 185772155 173 0
hScc1 BcellGSE12603 185778237 185778936 699 0
hScc1 G2GSE9613 185761332 185763946 2614 0
hScc1 G2GSE9613 185769132 185770187 1055 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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