AutismKB 2.0

Annotation Detail for ERBB4


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Basic Information Top
Gene Symbol:ERBB4 ( HER4,MGC138404,p180erbB4 )
Gene Full Name: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
Band: 2q34
Quick LinksEntrez ID:2066; OMIM: 600543; Uniprot ID:ERBB4_HUMAN; ENSEMBL ID: ENSG00000178568; HGNC ID: 3432
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
138N-linked (GlcNAc...).
174N-linked (GlcNAc...).
181N-linked (GlcNAc...) (Potential).
253N-linked (GlcNAc...).
358N-linked (GlcNAc...).
410N-linked (GlcNAc...).
473N-linked (GlcNAc...).
495N-linked (GlcNAc...).
548N-linked (GlcNAc...) (Potential).
576N-linked (GlcNAc...).
620N-linked (GlcNAc...) (Potential).
733Phosphotyrosine.
1035PPxY motif 1.
1056PPxY motif 2.
1162Phosphotyrosine; by autocatalysis (By
1188Phosphotyrosine; by autocatalysis (By
1258Phosphotyrosine; by autocatalysis (By
1284Phosphotyrosine; by autocatalysis (By
1301PPxY motif 3.
1308PDZ-binding.
Location(AA) Modifications Resource
138N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
174N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
181N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
253N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
358N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
410N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
473N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
495N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
548N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
576N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
620N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1056PhosphotyrosinePhospho.ELM 6.0
1162Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1188Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1188PhosphotyrosinePhospho.ELM 6.0
1242PhosphotyrosinePhospho.ELM 6.0
1258Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1284Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1284PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
25Phosphoserine(ATM)HMM predict
27Phosphoserine(IKK)HMM predict
40Phosphoserine(CK1)HMM predict
40Phosphoserine(CK2)HMM predict
53Phosphotyrosine(Syk)HMM predict
67Phosphoserine(CK1)HMM predict
96Phosphotyrosine(Jak)HMM predict
111Phosphotyrosine(Syk)HMM predict
138N-linkedHMM predict
144N-linkedHMM predict
148Phosphotyrosine(Abl)HMM predict
174N-linkedHMM predict
181N-linkedHMM predict
189S-palmitoylHMM predict
239Phosphoserine(ATM)HMM predict
253N-linkedHMM predict
269N-linkedHMM predict
293S-palmitoylHMM predict
347Phosphothreonine(PKC)HMM predict
358N-linkedHMM predict
363N-linkedHMM predict
394Phosphothreonine(PKC)HMM predict
410N-linkedHMM predict
473N-linkedHMM predict
476O-linkedHMM predict
495N-linkedHMM predict
548N-linkedHMM predict
576N-linkedHMM predict
620N-linkedHMM predict
626N-linkedHMM predict
635SulfotyrosineHMM predict
679Phosphoserine(PKG)HMM predict
699Phosphothreonine(MAPK)HMM predict
701O-linkedHMM predict
701Phosphoserine(IKK)HMM predict
754N-linkedHMM predict
789Phosphoserine(CDC2)HMM predict
875Phosphotyrosine(Syk)HMM predict
891S-palmitoylHMM predict
898Phosphothreonine(PKA)HMM predict
950Phosphotyrosine(SRC)HMM predict
984Phosphotyrosine(Syk)HMM predict
984Phosphotyrosine(Jak)HMM predict
999N-linkedHMM predict
1022Phosphotyrosine(Syk)HMM predict
1022Phosphotyrosine(INSR)HMM predict
1044N-linkedHMM predict
1046Phosphoserine(CK1)HMM predict
1051Phosphoserine(ATM)HMM predict
1056Phosphotyrosine(SRC)HMM predict
1056Phosphotyrosine(INSR)HMM predict
1086O-linkedHMM predict
1087O-linkedHMM predict
1108N-linkedHMM predict
1124Phosphoserine(CK1)HMM predict
1150Phosphotyrosine(Syk)HMM predict
1150Phosphotyrosine(INSR)HMM predict
1150Phosphotyrosine(Abl)HMM predict
1162Phosphotyrosine(Syk)HMM predict
1188Phosphotyrosine(INSR)HMM predict
1190N-linkedHMM predict
1193N-linkedHMM predict
1202SulfotyrosineHMM predict
1202Phosphotyrosine(EGFR)HMM predict
1242Phosphotyrosine(INSR)HMM predict
1244N-linkedHMM predict
1252Phosphothreonine(PKC)HMM predict
1252Phosphothreonine(PKA)HMM predict
1258SulfotyrosineHMM predict
1301TyrosineHMM predict
1304ArginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005235
  • Location:chr2 211948686-213111596
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 213120809 213121460 651 9538
FoxA1 MCF7MACSdata 213120628 213120955 327 9195
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 212235010 212235220 210 0
CBP T30-glioblastomaGSE21026 212625217 212626053 836 0
CTCF G2GSE9613 212076275 212076884 609 0
CTCF G2GSE9613 213110478 213111766 1288 0
ER MCF7GSE19013 211995968 211996520 552 0
ER MCF7GSE19013 212008121 212008725 604 0
FOXA1 MCF7GSE15244 211951193 211951983 790 0
FOXA1 MCF7GSE15244 211969826 211970307 481 0
FOXA1 MCF7GSE15244 211981354 211981922 568 0
FOXA1 MCF7GSE15244 212008112 212008329 217 0
FOXA1 MCF7GSE15244 212527471 212528062 591 0
FOXA1 MCF7GSE15244 212530684 212531391 707 0
FOXA1 MCF7GSE15244 212708732 212709245 513 0
FoxA1 MCF7MACSdata 211969810 211970121 311 0
FoxA1 MCF7MACSdata 211981464 211981784 320 0
FoxA1 MCF7MACSdata 212994907 212995093 186 0
H3K27me3 colorectalcancer 213109119 213110042 923 0
Myc hESGSE17917 212347404 212347634 230 0
NRSF JurkatGSE13047 212041970 212042337 367 0
NRSF JurkatSISSRdata 212042022 212042337 315 0
NRSF-mono JurkatQuESTdata 212041969 212042336 367 0
NRSF-mono JurkatQuESTdata 212419782 212419965 183 0
NRSF-poly JurkatQuESTdata 212041971 212042247 276 0
Nanog ESGSE20650 211953122 211953501 379 0
Nanog ESGSE20650 212339577 212340016 439 0
Nanog hESGSE18292 212899832 212900139 307 0
Nanog hESGSE18292 212956480 212956733 253 0
P300 T30-glioblastomaGSE21026 212604714 212605467 753 0
PAX3-FKHR RDGSE19063 212346605 212347290 685 0
Pol3 GM12878GSE19551 212094694 212095052 358 0
RARA MCF7GSE15244 211981392 211981890 498 0
RARA MCF7GSE15244 211995939 211996479 540 0
Stat6 IL-4-hr4GSE17850 212837061 212837624 563 0
TAF k562GSE8489 212053076 212053221 145 0
TFAP2C MCF7GSE21234 212408687 212408934 247 0
TFAP2C MCF7GSE21234 212500339 212500674 335 0
TFAP2C MCF7GSE21234 212512081 212512516 435 0
TFAP2C MCF7GSE21234 212827238 212827812 574 0
TFAP2C MCF7GSE21234 212845308 212845667 359 0
TFAP2C MCF7GSE21234 212867726 212868198 472 0
hScc1 G2GSE9613 212076275 212076884 609 0
hScc1 G2GSE9613 213110478 213111766 1288 0
p63 keratinocytesGSE17611 212669757 212670622 865 0
p63 keratinocytesGSE17611 212727065 212727828 763 0
p63 keratinocytesGSE17611 212957977 212958893 916 0
p63 keratinocytesGSE17611 213024355 213025220 865 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-122 hsa-mir-122 18 21253009
hsa-miR-122* hsa-mir-122 18 21253009
hsa-miR-141 hsa-mir-141 12 20420713
hsa-miR-141* hsa-mir-141 12 20420713
hsa-miR-142-3p hsa-mir-142 17 20420713
hsa-miR-149 hsa-mir-149 2 20420713
hsa-miR-149* hsa-mir-149 2 20420713
hsa-miR-184 hsa-mir-184 15 21253009
hsa-miR-185 hsa-mir-185 22 20420713
hsa-miR-185* hsa-mir-185 22 20420713
hsa-miR-19a hsa-mir-19a 13 19885849
hsa-miR-19a* hsa-mir-19a 13 19885849
hsa-miR-200a* hsa-mir-200a 1 20420713
hsa-miR-200c hsa-mir-200c 12 20420713
hsa-miR-200c* hsa-mir-200c 12 20420713
hsa-miR-206 hsa-mir-206 6 21253009
hsa-miR-21 hsa-mir-21 17 20420713
hsa-miR-21* hsa-mir-21 17 20420713
hsa-miR-210 hsa-mir-210 11 21253009
hsa-miR-217 hsa-mir-217 2 19885849
hsa-miR-224 hsa-mir-224 X 20420713
hsa-miR-302d hsa-mir-302d 4 19885849
hsa-miR-302d* hsa-mir-302d 4 19885849
hsa-miR-34a hsa-mir-34a 1 20420713
hsa-miR-34a* hsa-mir-34a 1 20420713
hsa-miR-372 hsa-mir-372 19 19885849
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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