Annotation Detail for ERG
Basic Information Top
| Gene Symbol: | ERG ( erg-3,p55 ) |
|---|---|
| Gene Full Name: | v-ets erythroblastosis virus E26 oncogene homolog (avian) |
| Band: | 21q22.2 |
| Quick Links | Entrez ID:2078; OMIM: 165080; Uniprot ID:ERG_HUMAN; ENSEMBL ID: ENSG00000157554; HGNC ID: 3446 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 93 | Phosphoserine. | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 85 | Phosphoserine | Phospho.ELM 6.0 |
| 93 | Phosphoserine. | Swiss-Prot 53.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 46 | Phosphoserine(CK1) | HMM predict |
| 48 | Phosphotyrosine(INSR) | HMM predict |
| 65 | Phosphoserine(ATM) | HMM predict |
| 78 | N-linked | HMM predict |
| 83 | N-linked | HMM predict |
| 87 | N-linked | HMM predict |
| 88 | Phosphoserine(IKK) | HMM predict |
| 124 | N-linked | HMM predict |
| 128 | N-linked | HMM predict |
| 235 | Phosphotyrosine(Jak) | HMM predict |
| 250 | Phosphothreonine(CDC2) | HMM predict |
| 250 | Phosphothreonine(CDK) | HMM predict |
| 250 | Phosphothreonine(MAPK) | HMM predict |
| 253 | Phosphoserine(IKK) | HMM predict |
| 259 | O-linked | HMM predict |
| 259 | Phosphoserine(IKK) | HMM predict |
| 261 | O-linked | HMM predict |
| 305 | Phosphoserine(CK1) | HMM predict |
| 308 | Phosphoserine(IKK) | HMM predict |
| 309 | N-linked | HMM predict |
| 400 | Phosphotyrosine(Jak) | HMM predict |
- RefSeq ID: NM_004449
- Location:chr21 38675670-38955487
- strand:-
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| KLF4 | hES | GSE17917 | 38966673 | 38966832 | 159 | 11265 |
| P300 | T30-glioblastoma | GSE21026 | 38955458 | 38956276 | 818 | 380 |
| P300 | T30-glioblastoma | GSE21026 | 38973401 | 38973983 | 582 | 18205 |
| hScc1 | Bcell | GSE12603 | 38963044 | 38963403 | 359 | 7736 |
| No data |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CTCF | CD4 | GSE12889 | 38799560 | 38799714 | 154 | 0 |
| CTCF | CD4 | SISSRdata | 38799560 | 38799714 | 154 | 0 |
| CTCF | G2 | GSE9613 | 38799084 | 38799583 | 499 | 0 |
| CTCF | G2 | GSE9613 | 38954237 | 38954528 | 291 | 0 |
| ER | MCF7 | GSE19013 | 38854636 | 38855584 | 948 | 0 |
| ER | MCF7 | GSE19013 | 38954784 | 38955658 | 874 | 0 |
| FOXA1 | MCF7 | GSE15244 | 38885536 | 38886411 | 875 | 0 |
| FOXA1 | MCF7 | GSE15244 | 38906768 | 38907399 | 631 | 0 |
| FOXA1 | MCF7 | GSE15244 | 38930124 | 38930560 | 436 | 0 |
| NRSF | Jurkat | GSE13047 | 38827588 | 38828182 | 594 | 0 |
| NRSF | mAb | Jurkat | 38801990 | 38802462 | 472 | 0 |
| NRSF | mAb | Jurkat | 38826772 | 38828276 | 1504 | 0 |
| NRSF | mAb | Jurkat | 38829282 | 38830271 | 989 | 0 |
| NRSF-mono | Jurkat | QuESTdata | 38827630 | 38828085 | 455 | 0 |
| NRSF-poly | Jurkat | QuESTdata | 38827618 | 38828202 | 584 | 0 |
| Nanog | hES | GSE18292 | 38799552 | 38799773 | 221 | 0 |
| RARA | MCF7 | GSE15244 | 38930124 | 38930339 | 215 | 0 |
| Sox2 | hES | GSE18292 | 38799427 | 38799911 | 484 | 0 |
| Stat6 | IL-4-hr1 | GSE17850 | 38800175 | 38801094 | 919 | 0 |
| Stat6 | IL-4-hr4 | GSE17850 | 38834659 | 38835132 | 473 | 0 |
| TFAP2C | MCF7 | GSE21234 | 38885510 | 38885956 | 446 | 0 |
| TFAP2C | MCF7 | GSE21234 | 38929998 | 38930633 | 635 | 0 |
| hScc1 | Bcell | GSE12603 | 38953991 | 38954418 | 427 | 0 |
| hScc1 | CdLS | GSE12603 | 38799084 | 38799802 | 718 | 0 |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-miR-133a | hsa-mir-133a-1 | 18 | 17344217 |
| hsa-miR-133a | hsa-mir-133a-2 | 20 | 17344217 |
| hsa-miR-133b | hsa-mir-133b | 6 | 17344217 |
| hsa-miR-148a | hsa-mir-148a | 7 | 20841507 |
| hsa-miR-148a | hsa-mir-148a | 7 | 18378853 |
| hsa-miR-148a* | hsa-mir-148a | 7 | 20841507 |
| hsa-miR-148a* | hsa-mir-148a | 7 | 18378853 |
| hsa-miR-181a | hsa-mir-181a-2 | 9 | 18809607 |
| hsa-miR-181a | hsa-mir-181a-1 | 1 | 18809607 |
| hsa-miR-181a* | hsa-mir-181a-1 | 1 | 18809607 |
| hsa-miR-181a-2* | hsa-mir-181a-2 | 9 | 18809607 |
| hsa-miR-181b | hsa-mir-181b-1 | 1 | 18809607 |
| hsa-miR-181b | hsa-mir-181b-2 | 9 | 18809607 |
| hsa-miR-181c | hsa-mir-181c | 19 | 18809607 |
| hsa-miR-181c* | hsa-mir-181c | 19 | 18809607 |
| hsa-miR-181d | hsa-mir-181d | 19 | 18809607 |
| hsa-miR-196a | hsa-mir-196a-1 | 17 | 20570349 |
| hsa-miR-196a | hsa-mir-196a-2 | 12 | 20570349 |
| hsa-miR-196b | hsa-mir-196b | 7 | 20570349 |
| hsa-miR-221 | hsa-mir-221 | X | 21378318 |
| hsa-miR-221* | hsa-mir-221 | X | 21378318 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 450 | mRNA repression | TRUE | miR-133 | ERG | in vitro reporter gene assay (Luciferase) | 17344217 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000157554 | "cardiac and skeletal muscles, cardiogenesis" | n_a | n_a | "squamous cell, lymphocyte, muscle cell, lymphoblast" | "benign tumour, carcinoma, leukaemia, sarcoma, malignant tumour" |
Cis-Nats regulation