AutismKB 2.0

Annotation Detail for MECOM


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Basic Information Top
Gene Symbol:MECOM ( AML1-EVI-1,EVI1,MDS1,MDS1-EVI1,MGC163392,MGC97004,PRDM3 )
Gene Full Name: MDS1 and EVI1 complex locus
Band: 3q26.2
Quick LinksEntrez ID:2122; OMIM: 165215; Uniprot ID:EVI1_HUMAN; ENSEMBL ID: ENSG00000085276,ENSG00000244102; HGNC ID: 3498
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
434Nuclear localization signal (Potential).
557CTBP-binding motif 1 (By similarity).
588CTBP-binding motif 2 (By similarity).
854Phosphoserine (By similarity).
858Phosphoserine.
860Phosphoserine.
Location(AA) Modifications Resource
860PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
21Phosphotyrosine(Jak)HMM predict
38O-linkedHMM predict
38Phosphothreonine(CDK)HMM predict
48Phosphoserine(ATM)HMM predict
48Phosphoserine(MAPK)HMM predict
52O-linkedHMM predict
53O-linkedHMM predict
62Phosphoserine(CDC2)HMM predict
62PhosphoserineHMM predict
131Phosphotyrosine(INSR)HMM predict
135Phosphoserine(PKG)HMM predict
135Phosphoserine(PKA)HMM predict
193S-palmitoylHMM predict
267Phosphoserine(IKK)HMM predict
270N-linkedHMM predict
275N-linkedHMM predict
322Phosphoserine(CDK)HMM predict
322Phosphoserine(CDC2)HMM predict
322PhosphoserineHMM predict
334N-linkedHMM predict
376Phosphoserine(CK1)HMM predict
377PhosphoserineHMM predict
377Phosphoserine(CK1)HMM predict
386Phosphoserine(CK2)HMM predict
391Phosphoserine(CK2)HMM predict
392Phosphoserine(CK2)HMM predict
392Phosphoserine(CK1)HMM predict
415Phosphoserine(CK1)HMM predict
436Phosphoserine(IKK)HMM predict
450Phosphotyrosine(INSR)HMM predict
452N-linkedHMM predict
567Phosphothreonine(MAPK)HMM predict
571O-linkedHMM predict
576Phosphothreonine(MAPK)HMM predict
576O-linkedHMM predict
580Phosphoserine(ATM)HMM predict
649Phosphothreonine(PKA)HMM predict
663Phosphoserine(CDC2)HMM predict
707Phosphoserine(ATM)HMM predict
707Phosphoserine(IKK)HMM predict
733Phosphotyrosine(INSR)HMM predict
747N-linkedHMM predict
761Phosphotyrosine(EGFR)HMM predict
771Phosphoserine(CK1)HMM predict
795S-palmitoylHMM predict
816N-linkedHMM predict
827Phosphoserine(CK2)HMM predict
827Phosphoserine(IKK)HMM predict
858Phosphoserine(ATM)HMM predict
869N-linkedHMM predict
882Phosphoserine(ATM)HMM predict
930Phosphotyrosine(EGFR)HMM predict
930Phosphotyrosine(Syk)HMM predict
930Phosphotyrosine(SRC)HMM predict
943Phosphoserine(CDC2)HMM predict
979Phosphotyrosine(SRC)HMM predict
979Phosphotyrosine(Syk)HMM predict
979Phosphotyrosine(INSR)HMM predict
979Phosphotyrosine(EGFR)HMM predict
980Phosphoserine(CK2)HMM predict
988O-linkedHMM predict
988Phosphoserine(CK1)HMM predict
1006Phosphoserine(PKA)HMM predict
1009Phosphotyrosine(Syk)HMM predict
1016Phosphoserine(ATM)HMM predict
1020Phosphoserine(IKK)HMM predict
1023Phosphoserine(CK1)HMM predict
1025O-linkedHMM predict
1029Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_005241
  • Location:chr3 170285243-170346786
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 170346735 170347221 486 192
CTCF G2GSE9613 170347836 170348163 327 1213
H3K4me3 colorectalcancer 170347149 170347645 496 611
H3K4me3 colorectalcancer 170347913 170348248 335 1294
PHF8 293TGSE20725 170346737 170347122 385 143
hScc1 G2GSE9613 170346580 170348464 1884 736
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 170267521 170267843 322 17562
CTCF G2GSE9613 170284436 170284579 143 736
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 170312351 170313399 1048 0
CTCF G2GSE9613 170330714 170330966 252 0
FOXA1 MCF7GSE15244 170286098 170286676 578 0
FOXA1 MCF7GSE15244 170297068 170297202 134 0
FOXA1 MCF7GSE15244 170305469 170305825 356 0
FOXA1 MCF7GSE15244 170307923 170308348 425 0
Nanog ESGSE20650 170286193 170286731 538 0
Nanog hESGSE18292 170286315 170286757 442 0
P300 T30-glioblastomaGSE21026 170286014 170287394 1380 0
P300 T30-glioblastomaGSE21026 170312300 170313370 1070 0
RARA MCF7GSE15244 170285871 170286716 845 0
RARG MCF7GSE15244 170285893 170286639 746 0
RARG MCF7GSE15244 170297068 170297202 134 0
TAF k562GSE8489 170344899 170347542 2643 0
hScc1 G2GSE9613 170333636 170333869 233 0
p63 keratinocytesGSE17611 170286147 170286996 849 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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