Annotation Detail for F2
Basic Information Top
| Gene Symbol: | F2 ( PT ) |
|---|---|
| Gene Full Name: | coagulation factor II (thrombin) |
| Band: | 11p11.2 |
| Quick Links | Entrez ID:2147; OMIM: 176930; Uniprot ID:THRB_HUMAN; ENSEMBL ID: ENSG00000180210; HGNC ID: 3535 |
| Relate to Another Database: | SFARIGene; denovo-db |
| Location(AA) | Modification | |
|---|---|---|
| 49 | 4-carboxyglutamate. | |
| 50 | 4-carboxyglutamate. | |
| 57 | 4-carboxyglutamate. | |
| 59 | 4-carboxyglutamate. | |
| 62 | 4-carboxyglutamate. | |
| 63 | 4-carboxyglutamate. | |
| 68 | 4-carboxyglutamate. | |
| 69 | 4-carboxyglutamate. | |
| 72 | 4-carboxyglutamate. | |
| 75 | 4-carboxyglutamate. | |
| 121 | N-linked (GlcNAc...). | |
| 143 | N-linked (GlcNAc...). | |
| 416 | N-linked (GlcNAc...) (complex). | |
| Location(AA) | Modifications | Resource |
|---|---|---|
| 49 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 50 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 57 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 59 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 62 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 63 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 68 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 69 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 72 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 75 | 4-carboxyglutamate. | Swiss-Prot 53.0 |
| 121 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
| 143 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
| 416 | N-linked (GlcNAc...). | Swiss-Prot 53.0 |
| Location(AA) | Modification | Resource |
|---|---|---|
| 24 | Phosphoserine(ATM) | HMM predict |
| 67 | Phosphotyrosine(Syk) | HMM predict |
| 95 | Phosphothreonine(MAPK) | HMM predict |
| 95 | Phosphothreonine(CDC2) | HMM predict |
| 121 | N-linked | HMM predict |
| 143 | N-linked | HMM predict |
| 196 | Phosphothreonine(CDK) | HMM predict |
| 196 | Phosphothreonine(MAPK) | HMM predict |
| 196 | Phosphothreonine(CDC2) | HMM predict |
| 205 | N-linked | HMM predict |
| 246 | Phosphoserine(CK1) | HMM predict |
| 299 | Phosphothreonine(CK2) | HMM predict |
| 368 | Phosphoserine(CK2) | HMM predict |
| 385 | Phosphoserine(CDC2) | HMM predict |
| 416 | N-linked | HMM predict |
| 420 | N-linked | HMM predict |
| 477 | Phosphotyrosine(INSR) | HMM predict |
- RefSeq ID: NM_000506
- Location:chr11 46697330-46717630
- strand:+
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| CBP | T30-glioblastoma | GSE21026 | 46692047 | 46693297 | 1250 | 4659 |
| FOXA1 | MCF7 | GSE15244 | 46696246 | 46696637 | 391 | 889 |
| Fos | K562 | GSE19551 | 46692687 | 46692909 | 222 | 4533 |
| P300 | T30-glioblastoma | GSE21026 | 46692366 | 46693287 | 921 | 4504 |
| No data |
| Transcrip Factors | Experimental Cell | Database | TF Binding Start | TF Binding End | TF Binding Length | The Distance to Gene |
|---|---|---|---|---|---|---|
| H3ac | HepG2 | E | 46698032 | 46699111 | 1079 | 0 |
| H3ac | HepG2 | E | 46699487 | 46699779 | 292 | 0 |
| Oct1 | H2O2-Hela | GSE14283 | 46705383 | 46705423 | 40 | 0 |
| Oct1 | H2O2-Hela | GSE14283 | 46707691 | 46707727 | 36 | 0 |
| Oct1 | Hela | GSE14283 | 46702611 | 46702644 | 33 | 0 |
| Oct1 | Hela | GSE14283 | 46705383 | 46705423 | 40 | 0 |
| Oct1 | Hela | GSE14283 | 46707692 | 46707722 | 30 | 0 |
| Micro RNA Name | Stem Loop Name | The chromosome that miRNA located | Publication |
|---|---|---|---|
| hsa-let-7b | hsa-let-7b | 22 | 18668040 |
| hsa-let-7b* | hsa-let-7b | 22 | 18668040 |
| hsa-miR-1 | hsa-mir-1-2 | 18 | 18668040 |
| hsa-miR-1 | hsa-mir-1-1 | 20 | 18668040 |
| hsa-miR-155 | hsa-mir-155 | 21 | 18668040 |
| hsa-miR-155* | hsa-mir-155 | 21 | 18668040 |
| hsa-miR-16 | hsa-mir-16-1 | 13 | 18668040 |
| hsa-miR-16 | hsa-mir-16-2 | 3 | 18668040 |
| hsa-miR-30a | hsa-mir-30a | 6 | 18668040 |
| hsa-miR-30a* | hsa-mir-30a | 6 | 18668040 |
| hsa-miR-30b | hsa-mir-30b | 8 | 18668040 |
| hsa-miR-30b* | hsa-mir-30b | 8 | 18668040 |
| hsa-miR-30c | hsa-mir-30c-2 | 6 | 18668040 |
| hsa-miR-30c | hsa-mir-30c-1 | 1 | 18668040 |
| hsa-miR-30c-1* | hsa-mir-30c-1 | 1 | 18668040 |
| hsa-miR-30c-2* | hsa-mir-30c-2 | 6 | 18668040 |
| hsa-miR-30d | hsa-mir-30d | 8 | 18668040 |
| hsa-miR-30d* | hsa-mir-30d | 8 | 18668040 |
| hsa-miR-30e | hsa-mir-30e | 1 | 18668040 |
| hsa-miR-30e* | hsa-mir-30e | 1 | 18668040 |
| ID in Tarbase | Data Type | Support Type | miRNA | Gene | Direct Support | Publication |
|---|---|---|---|---|---|---|
| 864 | Unknown | pSILAC | let-7b | F2 | down 50-25% | 18668040 |
| 866 | Unknown | pSILAC | let-7b | F2 | down 50-25% | 18668040 |
| 918 | Unknown | pSILAC | LNA_let-7b | F2 | up >75% | 18668040 |
| 920 | Unknown | pSILAC | LNA_let-7b | F2 | up <25% | 18668040 |
| 989 | Unknown | pSILAC | miR-155 | F2 | down 50-25% | 18668040 |
| 1022 | Unknown | pSILAC | miR-16 | F2 | down 50-25% | 18668040 |
| 1038 | Unknown | pSILAC | miR-16 | F2 | down 50-25% | 18668040 |
| 1039 | Unknown | pSILAC | miR-16 | F2 | down 75-50% | 18668040 |
| 1058 | Unknown | pSILAC | miR-16 | F2 | down 50-25% | 18668040 |
| 1166 | Unknown | pSILAC | miR-1 | F2 | down 75-50% | 18668040 |
| 1303 | Unknown | pSILAC | miR-30 | F2 | down 50-25% | 18668040 |
| Ensembl | Protein Type | Differentially expressed in | Pathology or Event | Mis Regulation | Gene Expression | Tumour Involvement |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a | |
| ENSG00000180210 | n_a | n_a | n_a | n_a | n_a |
Cis-Nats regulation