AutismKB 2.0

Annotation Detail for PTK2B


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Basic Information Top
Gene Symbol:PTK2B ( CADTK,CAKB,FADK2,FAK2,PKB,PTK,PYK2,RAFTK )
Gene Full Name: PTK2B protein tyrosine kinase 2 beta
Band: 8p21.2
Quick LinksEntrez ID:2185; OMIM: 601212; Uniprot ID:FAK2_HUMAN; ENSEMBL ID: ENSG00000120899; HGNC ID: 9612
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2Phosphoserine.
15Phosphothreonine.
361Phosphoserine.
375Phosphoserine.
389Phosphoserine.
392Phosphoserine.
394Phosphoserine.
396Phosphoserine.
399Phosphoserine.
402Phosphotyrosine.
440Phosphotyrosine (By similarity).
559Phosphoserine.
579Phosphotyrosine; by autocatalysis.
580Phosphotyrosine.
583Phosphoserine.
722Phosphotyrosine.
746Phosphoserine.
758Phosphoserine.
762Phosphoserine.
765Phosphothreonine.
778Phosphoserine.
819Phosphotyrosine.
834Phosphotyrosine.
839Phosphoserine.
842Phosphothreonine.
849Phosphotyrosine.
866Phosphoserine.
881Phosphotyrosine (By similarity).
966Phosphothreonine.
Location(AA) Modifications Resource
375Phosphoserine.Swiss-Prot 53.0
402Phosphotyrosine.Swiss-Prot 53.0
402Phosphotyrosine (Syk;PYK2)Phospho.ELM 6.0
579Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
579PhosphotyrosinePhospho.ELM 6.0
580Phosphotyrosine.Swiss-Prot 53.0
580PhosphotyrosinePhospho.ELM 6.0
881Phosphotyrosine (By similarity).Swiss-Prot 53.0
881PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
15Phosphothreonine(PKC)HMM predict
110Phosphothreonine(PKC)HMM predict
162Phosphotyrosine(INSR)HMM predict
162Phosphotyrosine(Syk)HMM predict
265Phosphotyrosine(Jak)HMM predict
274N-linkedHMM predict
291Phosphoserine(ATM)HMM predict
351Phosphotyrosine(Jak)HMM predict
375Phosphoserine(CK1)HMM predict
389Phosphoserine(PKG)HMM predict
402Phosphotyrosine(Syk)HMM predict
402Phosphotyrosine(INSR)HMM predict
402SulfotyrosineHMM predict
402Phosphotyrosine(EGFR)HMM predict
579PhosphotyrosineHMM predict
579Phosphotyrosine(INSR)HMM predict
579Phosphotyrosine(Syk)HMM predict
579Phosphotyrosine(Jak)HMM predict
580Phosphotyrosine(EGFR)HMM predict
580Phosphotyrosine(Syk)HMM predict
603Phosphothreonine(PKA)HMM predict
604Phosphothreonine(PKA)HMM predict
683Phosphotyrosine(Syk)HMM predict
747Phosphoserine(CDC2)HMM predict
842Phosphothreonine(CDC2)HMM predict
842Phosphothreonine(MAPK)HMM predict
842Phosphothreonine(CDK)HMM predict
842PhosphothreonineHMM predict
881Phosphotyrosine(Syk)HMM predict
906Phosphotyrosine(Abl)HMM predict
916Phosphothreonine(PKC)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004103
  • Location:chr8 27224915-27372819
  • strand:+
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 27228698 27229017 319 0
CTCF CD4GSE12889 27237119 27237557 438 0
CTCF CD4SISSRdata 27228698 27229017 319 0
CTCF CD4SISSRdata 27237119 27237557 438 0
CTCF G2GSE9613 27228784 27229109 325 0
CTCF G2GSE9613 27236952 27238312 1360 0
FOXA1 DLD1GSE12801 27236164 27237024 860 0
FOXA1 MCF7GSE15244 27236362 27236783 421 0
Fos K562GSE19551 27224584 27225426 842 0
GABP k562GSE8489 27224956 27225624 668 0
H3K4me2 HCT116GSE10453 27225213 27225624 411 0
Oct1 H2O2-HelaGSE14283 27228252 27228279 27 0
Oct1 HelaGSE14283 27228252 27228281 29 0
Rb GrowingGSE19898 27224747 27225087 340 0
Rb QuiescentGSE19898 27224715 27225292 577 0
hScc1 BcellGSE12603 27228784 27229156 372 0
hScc1 BcellGSE12603 27236987 27237817 830 0
hScc1 CdLSGSE12603 27228784 27229156 372 0
hScc1 CdLSGSE12603 27236916 27237854 938 0
hScc1 CdLSGSE12603 27238601 27239192 591 0
hScc1 G2GSE9613 27228784 27229071 287 0
hScc1 G2GSE9613 27237024 27237738 714 0
p130 QuiescentGSE19898 27224736 27225158 422 0
p130 SenescentGSE19898 27224786 27225326 540 0
p130 shRbQuiescentGSE19898 27224786 27225233 447 0
p130 shRbSenescentGSE19898 27224832 27225162 330 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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