Annotation Detail for FASN

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Basic Information Top

Gene Symbol:	FASN ( FAS,MGC14367,MGC15706,OA-519,SDR27X1 )
Gene Full Name:	fatty acid synthase
Band:	17q25.3
Quick Links	Entrez ID:2194; OMIM: 600212; Uniprot ID:FAS_HUMAN; ENSEMBL ID: ENSG00000169710; HGNC ID: 3594
Relate to Another Database:	SFARIGene; denovo-db

General

Expression

Regulation

Pathways, Diseases and Drugs

PTM

TF binding site

miRNA targets

Cis-NATs

Post Translation Modification

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PTM Sites from Uniprot:17 results
Experimental PTM Sites from dbPTM:3 results
Predicted PTM Sites by profile HMM from dbPTM:56 results

Location(AA)	Modification
1	N-acetylmethionine.
70	N6-acetyllysine.
207	Phosphoserine.
298	N6-acetyllysine.
436	N6-acetyllysine.
528	N6-acetyllysine.
673	N6-acetyllysine.
1704	N6-acetyllysine.
1704	N6-(pyridoxal phosphate)lysine (By
1752	N6-acetyllysine.
1771	N6-acetyllysine.
1847	N6-acetyllysine.
1995	N6-acetyllysine.
2156	O-(pantetheine 4'-phosphoryl)serine (By
2198	Phosphoserine.
2204	Phosphothreonine.
2236	Phosphoserine.

Location(AA)	Modifications	Resource
1	N-acetylmethionine.	Swiss-Prot 53.0
2204	Phosphothreonine.	Swiss-Prot 53.0
2204	Phosphothreonine	Phospho.ELM 6.0

Location(AA)	Modification	Resource
114	Phosphoserine(CK2)	HMM predict
159	O-linked	HMM predict
234	Phosphothreonine(PKC)	HMM predict
289	Phosphotyrosine(EGFR)	HMM predict
289	Phosphotyrosine(Jak)	HMM predict
430	Phosphothreonine(MAPK)	HMM predict
544	Phosphoserine(CK2)	HMM predict
730	Phosphoserine(PKG)	HMM predict
741	Phosphoserine(MAPK)	HMM predict
852	N-linked	HMM predict
854	O-linked	HMM predict
856	Phosphoserine(CDC2)	HMM predict
856	Phosphoserine(CDK)	HMM predict
891	Phosphotyrosine(Jak)	HMM predict
974	Phosphoserine(CDC2)	HMM predict
976	O-linked	HMM predict
976	Phosphothreonine(MAPK)	HMM predict
976	Phosphothreonine(CDC2)	HMM predict
976	Phosphothreonine(CDK)	HMM predict
978	N-linked	HMM predict
1037	Phosphoserine(IKK)	HMM predict
1053	Phosphothreonine(PKA)	HMM predict
1261	Phosphoserine(MAPK)	HMM predict
1327	Phosphoserine(IKK)	HMM predict
1367	Phosphotyrosine(Abl)	HMM predict
1407	Phosphothreonine(PKA)	HMM predict
1407	Phosphothreonine(CDK)	HMM predict
1438	Phosphoserine(CK1)	HMM predict
1476	N-linked	HMM predict
1478	Phosphoserine(CK1)	HMM predict
1479	Phosphoserine(CK1)	HMM predict
1597	Phosphoserine(IKK)	HMM predict
1639	N-linked	HMM predict
1697	Phosphothreonine(PKA)	HMM predict
1707	Phosphotyrosine(EGFR)	HMM predict
1707	Phosphotyrosine(Jak)	HMM predict
1719	Phosphoserine(IKK)	HMM predict
1727	Phosphoserine(IKK)	HMM predict
1775	Phosphoserine(ATM)	HMM predict
1788	N-linked	HMM predict
1801	N-linked	HMM predict
1948	Phosphoserine(CK1)	HMM predict
1982	N-linked	HMM predict
2076	N-linked	HMM predict
2165	Phosphothreonine(PKC)	HMM predict
2183	Phosphothreonine(PKC)	HMM predict
2265	Phosphoserine(CK1)	HMM predict
2265	Phosphoserine(PKG)	HMM predict
2302	Phosphotyrosine(SRC)	HMM predict
2319	Phosphoserine(ATM)	HMM predict
2326	Phosphoserine(IKK)	HMM predict
2343	Phosphotyrosine(INSR)	HMM predict
2343	Phosphotyrosine(SRC)	HMM predict
2356	Phosphothreonine(MAPK)	HMM predict
2463	N-linked	HMM predict
2507	Phosphoserine(PKG)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_004104
Location:chr17 77629503-77649394
strand:-

Upstream the gene:9 results
Downstream the gene:0 results
Inside the gene:15 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	77649319	77649508	189	19
CTCF	CD4	SISSRdata	77649319	77649508	189	19
CTCF	G2	GSE9613	77648894	77650065	1171	85
Fos	K562	GSE19551	77649251	77650364	1113	413
NFkBII	GM10847	GSE19485	77648905	77650848	1943	482
NFkBII	GM15510	GSE19485	77648784	77650601	1817	298
PHF8	HeLa	GSE20725	77648032	77650849	2817	46
hScc1	CdLS	GSE12603	77648419	77650462	2043	46
p130	shRbQuiescent	GSE19898	77650547	77651048	501	1403

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	77634625	77635384	759
CTCF	G2	GSE9613	77636620	77636951	331
CTCF	G2	GSE9613	77641405	77641834	429
CTCF	G2	GSE9613	77644524	77645240	716
CTCF	G2	GSE9613	77647636	77648574	938
P300	T30-glioblastoma	GSE21026	77648317	77650324	2007
PHF8	293T	GSE20725	77648228	77650557	2329
PHF8	Hs68plusFBS	GSE20725	77648242	77650318	2076
hScc1	Bcell	GSE12603	77632833	77634882	2049
hScc1	Bcell	GSE12603	77635208	77635826	618
hScc1	Bcell	GSE12603	77636470	77636763	293
hScc1	Bcell	GSE12603	77639147	77639516	369
hScc1	Bcell	GSE12603	77647509	77647848	339
hScc1	Bcell	GSE12603	77648347	77649780	1433
p130	Senescent	GSE19898	77649272	77649485	213

Validated miRNA targets

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miR Walk:168 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7a	hsa-let-7a-1	9	21228813
hsa-let-7a	hsa-let-7a-2	11	21228813
hsa-let-7a	hsa-let-7a-3	22	21228813
hsa-let-7a	hsa-let-7a-1	9	21228813
hsa-let-7a	hsa-let-7a-2	11	21228813
hsa-let-7a	hsa-let-7a-3	22	21228813
hsa-let-7a*	hsa-let-7a-1	9	21228813
hsa-let-7a*	hsa-let-7a-3	22	21228813
hsa-let-7a*	hsa-let-7a-1	9	21228813
hsa-let-7a*	hsa-let-7a-3	22	21228813
hsa-let-7b	hsa-let-7b	22	21228813
hsa-let-7b	hsa-let-7b	22	21228813
hsa-let-7b*	hsa-let-7b	22	21228813
hsa-let-7b*	hsa-let-7b	22	21228813
hsa-let-7c	hsa-let-7c	21	21228813
hsa-let-7c	hsa-let-7c	21	21228813
hsa-let-7c*	hsa-let-7c	21	21228813
hsa-let-7c*	hsa-let-7c	21	21228813
hsa-let-7d	hsa-let-7d	9	21228813
hsa-let-7d	hsa-let-7d	9	21228813
hsa-let-7d*	hsa-let-7d	9	21228813
hsa-let-7d*	hsa-let-7d	9	21228813
hsa-let-7e	hsa-let-7e	19	21228813
hsa-let-7e	hsa-let-7e	19	21228813
hsa-let-7e*	hsa-let-7e	19	21228813
hsa-let-7e*	hsa-let-7e	19	21228813
hsa-let-7f	hsa-let-7f-1	9	21228813
hsa-let-7f	hsa-let-7f-2	X	21228813
hsa-let-7f	hsa-let-7f-1	9	21228813
hsa-let-7f	hsa-let-7f-2	X	21228813
hsa-let-7f-1*	hsa-let-7f-1	9	21228813
hsa-let-7f-1*	hsa-let-7f-1	9	21228813
hsa-let-7f-2*	hsa-let-7f-2	X	21228813
hsa-let-7f-2*	hsa-let-7f-2	X	21228813
hsa-let-7g	hsa-let-7g	3	21228813
hsa-let-7g	hsa-let-7g	3	21228813
hsa-let-7g*	hsa-let-7g	3	21228813
hsa-let-7g*	hsa-let-7g	3	21228813
hsa-let-7i	hsa-let-7i	12	21228813
hsa-let-7i	hsa-let-7i	12	21228813
hsa-let-7i*	hsa-let-7i	12	21228813
hsa-let-7i*	hsa-let-7i	12	21228813
hsa-miR-107	hsa-mir-107	10	21120623
hsa-miR-107	hsa-mir-107	10	21120623
hsa-miR-122	hsa-mir-122	18	20124555
hsa-miR-122	hsa-mir-122	18	20124555
hsa-miR-122*	hsa-mir-122	18	20124555
hsa-miR-122*	hsa-mir-122	18	20124555
hsa-miR-132	hsa-mir-132	17	20497147
hsa-miR-132	hsa-mir-132	17	20497147
hsa-miR-132*	hsa-mir-132	17	20497147
hsa-miR-132*	hsa-mir-132	17	20497147
hsa-miR-143	hsa-mir-143	5	19464056
hsa-miR-143	hsa-mir-143	5	19464056
hsa-miR-143*	hsa-mir-143	5	19464056
hsa-miR-143*	hsa-mir-143	5	19464056
hsa-miR-146a	hsa-mir-146a	5	20459811
hsa-miR-146a	hsa-mir-146a	5	19965651
hsa-miR-146a	hsa-mir-146a	5	19596990
hsa-miR-146a	hsa-mir-146a	5	20459811
hsa-miR-146a	hsa-mir-146a	5	19965651
hsa-miR-146a	hsa-mir-146a	5	19596990
hsa-miR-146a*	hsa-mir-146a	5	20459811
hsa-miR-146a*	hsa-mir-146a	5	19965651
hsa-miR-146a*	hsa-mir-146a	5	19596990
hsa-miR-146a*	hsa-mir-146a	5	20459811
hsa-miR-146a*	hsa-mir-146a	5	19965651
hsa-miR-146a*	hsa-mir-146a	5	19596990
hsa-miR-146b-3p	hsa-mir-146b	10	20029416
hsa-miR-146b-3p	hsa-mir-146b	10	20029416
hsa-miR-146b-5p	hsa-mir-146b	10	20029416
hsa-miR-146b-5p	hsa-mir-146b	10	20029416
hsa-miR-150	hsa-mir-150	19	20497147
hsa-miR-150	hsa-mir-150	19	20497147
hsa-miR-150*	hsa-mir-150	19	20497147
hsa-miR-150*	hsa-mir-150	19	20497147
hsa-miR-155	hsa-mir-155	21	19650740
hsa-miR-155	hsa-mir-155	21	19650740
hsa-miR-155*	hsa-mir-155	21	19650740
hsa-miR-155*	hsa-mir-155	21	19650740
hsa-miR-197	hsa-mir-197	1	20497147
hsa-miR-197	hsa-mir-197	1	20497147
hsa-miR-199a-5p	hsa-mir-199a-1	19	20814244
hsa-miR-199a-5p	hsa-mir-199a-2	1	20814244
hsa-miR-199a-5p	hsa-mir-199a-1	19	20814244
hsa-miR-199a-5p	hsa-mir-199a-2	1	20814244
hsa-miR-21	hsa-mir-21	17	20814244
hsa-miR-21	hsa-mir-21	17	20404348
hsa-miR-21	hsa-mir-21	17	17991735
hsa-miR-21	hsa-mir-21	17	20814244
hsa-miR-21	hsa-mir-21	17	20404348
hsa-miR-21	hsa-mir-21	17	17991735
hsa-miR-21*	hsa-mir-21	17	20814244
hsa-miR-21*	hsa-mir-21	17	20404348
hsa-miR-21*	hsa-mir-21	17	17991735
hsa-miR-21*	hsa-mir-21	17	20814244
hsa-miR-21*	hsa-mir-21	17	20404348
hsa-miR-21*	hsa-mir-21	17	17991735
hsa-miR-23a	hsa-mir-23a	19	19513126
hsa-miR-23a	hsa-mir-23a	19	19513126
hsa-miR-23a*	hsa-mir-23a	19	19513126
hsa-miR-23a*	hsa-mir-23a	19	19513126
hsa-miR-24	hsa-mir-24-2	19	19513126
hsa-miR-24	hsa-mir-24-2	19	19513126
hsa-miR-24-2*	hsa-mir-24-2	19	19513126
hsa-miR-24-2*	hsa-mir-24-2	19	19513126
hsa-miR-27a	hsa-mir-27a	19	19513126
hsa-miR-27a	hsa-mir-27a	19	19513126
hsa-miR-27a*	hsa-mir-27a	19	19513126
hsa-miR-27a*	hsa-mir-27a	19	19513126
hsa-miR-28-3p	hsa-mir-28	3	20497147
hsa-miR-28-3p	hsa-mir-28	3	20497147
hsa-miR-335	hsa-mir-335	7	19460359
hsa-miR-335	hsa-mir-335	7	19460359
hsa-miR-335*	hsa-mir-335	7	19460359
hsa-miR-335*	hsa-mir-335	7	19460359
hsa-miR-34a	hsa-mir-34a	1	20734047
hsa-miR-34a	hsa-mir-34a	1	20213410
hsa-miR-34a	hsa-mir-34a	1	20734047
hsa-miR-34a	hsa-mir-34a	1	20213410
hsa-miR-34a*	hsa-mir-34a	1	20734047
hsa-miR-34a*	hsa-mir-34a	1	20213410
hsa-miR-34a*	hsa-mir-34a	1	20734047
hsa-miR-34a*	hsa-mir-34a	1	20213410
hsa-miR-34b	hsa-mir-34b	11	20213410
hsa-miR-34b	hsa-mir-34b	11	20213410
hsa-miR-34b*	hsa-mir-34b	11	20213410
hsa-miR-34b*	hsa-mir-34b	11	20213410
hsa-miR-34c-3p	hsa-mir-34c	11	20213410
hsa-miR-34c-3p	hsa-mir-34c	11	20213410
hsa-miR-34c-5p	hsa-mir-34c	11	20213410
hsa-miR-34c-5p	hsa-mir-34c	11	20213410
hsa-miR-363	hsa-mir-363	X	20459811
hsa-miR-363	hsa-mir-363	X	20459811
hsa-miR-363*	hsa-mir-363	X	20459811
hsa-miR-363*	hsa-mir-363	X	20459811
hsa-miR-370	hsa-mir-370	14	20124555
hsa-miR-370	hsa-mir-370	14	20124555
hsa-miR-433	hsa-mir-433	14	20497147
hsa-miR-433	hsa-mir-433	14	20497147
hsa-miR-498	hsa-mir-498	19	20459811
hsa-miR-498	hsa-mir-498	19	20459811
hsa-miR-511	hsa-mir-511-1	10	20497147
hsa-miR-511	hsa-mir-511-1	10	20497147
hsa-miR-511	hsa-mir-511-2	10	20497147
hsa-miR-511	hsa-mir-511-2	10	20497147
hsa-miR-511	hsa-mir-511-1	10	20497147
hsa-miR-511	hsa-mir-511-1	10	20497147
hsa-miR-511	hsa-mir-511-2	10	20497147
hsa-miR-511	hsa-mir-511-2	10	20497147
hsa-miR-517*	hsa-mir-517a	19	20497147
hsa-miR-517*	hsa-mir-517a	19	20497147
hsa-miR-517a	hsa-mir-517a	19	20497147
hsa-miR-517a	hsa-mir-517a	19	20497147
hsa-miR-601	hsa-mir-601	9	19889580
hsa-miR-601	hsa-mir-601	9	19889580
hsa-miR-671-3p	hsa-mir-671	7	20497147
hsa-miR-671-3p	hsa-mir-671	7	20497147
hsa-miR-671-5p	hsa-mir-671	7	20497147
hsa-miR-671-5p	hsa-mir-671	7	20497147
hsa-miR-99a	hsa-mir-99a	21	20497147
hsa-miR-99a	hsa-mir-99a	21	20497147
hsa-miR-99a*	hsa-mir-99a	21	20497147
hsa-miR-99a*	hsa-mir-99a	21	20497147
hsa-miR-99b	hsa-mir-99b	19	20497147
hsa-miR-99b	hsa-mir-99b	19	20497147
hsa-miR-99b*	hsa-mir-99b	19	20497147
hsa-miR-99b*	hsa-mir-99b	19	20497147

Cis-Nats regulation

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Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

AutismKB 2.0

Annotation Detail for FASN

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics