Annotation Detail for HYLS1

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Basic Information Top

Gene Symbol:	HYLS1 ( FLJ32915,HLS )
Gene Full Name:	hydrolethalus syndrome 1
Band:	11q24.2
Quick Links	Entrez ID:219844; OMIM: 610693; Uniprot ID:HYLS1_HUMAN; ENSEMBL ID: ENSG00000198331; HGNC ID: 26558
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:0 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:7 results

No data

Location(AA)	Modification	Resource
83	Phosphoserine(IKK)	HMM predict
116	Phosphoserine(CK1)	HMM predict
120	Phosphoserine(CK1)	HMM predict
120	Phosphoserine(IKK)	HMM predict
160	Phosphotyrosine(Syk)	HMM predict
194	Phosphoserine(IKK)	HMM predict
293	Proline	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_145014
Location:chr11 125258718-125275748
strand:+

Upstream the gene:3 results
Downstream the gene:0 results
Inside the gene:7 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	125249716	125250028	312	8847
CTCF	CD4	SISSRdata	125249716	125250028	312	8847
Myc	K562	GSE19551	125249706	125249885	179	8923

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	DLD1	GSE12801	125267120	125267896	776	0
Fos	K562	GSE19551	125262460	125262996	536	0
PHF8	HeLa	GSE20725	125262592	125263462	870	0
PHF8	Hs68minusFBS	GSE20725	125262634	125263432	798	0
PHF8	Hs68plusFBS	GSE20725	125262526	125263420	894	0
hScc1	Bcell	GSE12603	125262057	125262522	465	0
hScc1	CdLS	GSE12603	125262057	125262634	577	0

Validated miRNA targets

miR Walk:2 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-155	hsa-mir-155	21	16041695
hsa-miR-155*	hsa-mir-155	21	16041695

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
5391	mRNA	HYLS1	chr11	125258718	125275749	7159	mRNA	PUS3	chr11	125268590	125278315	Non-exonic Bidirectional (NOB) pairs

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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