AutismKB 2.0

Annotation Detail for LRTOMT


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Basic Information Top
Gene Symbol:LRTOMT ( COMT2,DFNB63,FLJ52451,LRRC51,LRTOMT1,LRTOMT2 )
Gene Full Name: leucine rich transmembrane and 0-methyltransferase domain containing
Band: 11q13.4
Quick LinksEntrez ID:220074; OMIM: 611451,612414; Uniprot ID:LRC51_HUMAN; ENSEMBL ID: ENSG00000184154,ENSG00000241994; HGNC ID: 25033
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
No data
Location(AA) Modification Resource
6Phosphotyrosine(INSR)HMM predict
8N-linkedHMM predict
49Phosphoserine(IKK)HMM predict
145Phosphotyrosine(EGFR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_145309
  • Location:chr11 71469552-71485583
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 71468751 71470118 1367 118
FOXA1 MCF7GSE15244 71469264 71469804 540 19
PHF8 293TGSE20725 71468719 71470115 1396 136
PHF8 HeLaGSE20725 71468912 71470173 1261 10
Rb SenescentGSE19898 71469134 71469900 766 36
Rb shRbQuiescentGSE19898 71469140 71469749 609 108
Rb shRbSenescenceGSE19898 71469188 71469741 553 88
TFAP2C MCF7GSE21234 71469167 71469918 751 10
p130 shRbQuiescentGSE19898 71468720 71470054 1334 166
p130 shRbSenescentGSE19898 71468847 71469954 1107 152
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 71479873 71480284 411 0
CTCF CD4SISSRdata 71479873 71480284 411 0
GATA3 MCF7GSE15244 71477236 71477977 741 0
H3ac HepG2E 71469367 71469804 437 0
H3ac HepG2E 71470175 71471245 1070 0
RARG MCF7GSE15244 71479442 71480180 738 0
Rb GrowingGSE19898 71469492 71469776 284 0
Rb GrowingGSE19898 71478888 71479028 140 0
Rb QuiescentGSE19898 71469463 71469899 436 0
TAF HelaGSE8489 71470175 71471351 1176 0
TAF HelaGSE8489 71473847 71474227 380 0
TFAP2C MCF7GSE21234 71470405 71471188 783 0
hScc1 CdLSGSE12603 71479806 71480617 811 0
hScc1 G2GSE9613 71479873 71480427 554 0
p63 keratinocytesGSE17611 71472416 71473172 756 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018