AutismKB 2.0

Annotation Detail for FEN1


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Basic Information Top
Gene Symbol:FEN1 ( FEN-1,MF1,RAD2 )
Gene Full Name: flap structure-specific endonuclease 1
Band: 11q12.2
Quick LinksEntrez ID:2237; OMIM: 600393; Uniprot ID:FEN1_HUMAN; ENSEMBL ID: ENSG00000168496; HGNC ID: 3650
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
19Symmetric dimethylarginine; by PRMT5.
80N6-acetyllysine.
100Symmetric dimethylarginine; by PRMT5.
104Symmetric dimethylarginine; by PRMT5.
187Phosphoserine; by CDK2.
192Symmetric dimethylarginine; by PRMT5.
267N6-acetyllysine.
354N6-acetyllysine.
375N6-acetyllysine.
377N6-acetyllysine.
380N6-acetyllysine.
Location(AA) Modifications Resource
187Phosphoserine (CDK1)Phospho.ELM 6.0
354N6-acetyllysine.Swiss-Prot 53.0
375N6-acetyllysine.Swiss-Prot 53.0
377N6-acetyllysine.Swiss-Prot 53.0
380N6-acetyllysine.Swiss-Prot 53.0
Location(AA) Modification Resource
268Phosphotyrosine(Syk)HMM predict
317Phosphoserine(CK1)HMM predict
329Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_004111
  • Location:chr11 61316725-61321282
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p130 QuiescentGSE19898 61316296 61317139 843 8
p130 shRbQuiescentGSE19898 61316083 61317307 1224 31
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 61321265 61321607 342 154
CTCF CD4SISSRdata 61321265 61321607 342 154
Sox2 hESGSE18292 61321343 61321644 301 211
hScc1 CdLSGSE12603 61321080 61321635 555 75
hScc1 G2GSE9613 61320930 61321672 742 19
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 61316371 61317381 1010 0
E2F4 SGSE7516 61316407 61317448 1041 0
ETS1 JurkatGSE17954 61315814 61317688 1874 0
GABP k562GSE8489 61315823 61317938 2115 0
H3K4me2 HCT116GSE10453 61317757 61317974 217 0
H3ac HepG2E 61315823 61317974 2151 0
H3ac HepG2E 61318760 61319382 622 0
LIN54 G0GSE7516 61316432 61317298 866 0
LIN9 G0GSE7516 61316151 61317472 1321 0
LIN9 SGSE7516 61316258 61317472 1214 0
PHF8 HeLaGSE20725 61315973 61317597 1624 0
Rb GrowingGSE19898 61316768 61317358 590 0
Rb QuiescentGSE19898 61316561 61317252 691 0
Rb SenescentGSE19898 61316387 61317409 1022 0
Rb SenescentGSE19898 61317584 61317897 313 0
Rb shRbSenescenceGSE19898 61316797 61317394 597 0
TAF HelaGSE8489 61316999 61317974 975 0
USF1 HepG2E 61315823 61317974 2151 0
USF1 HepG2E 61318489 61319382 893 0
USF2 HepG2E 61315823 61317974 2151 0
hScc1 BcellGSE12603 61321044 61321490 446 0
p130 QuiescentGSE19898 61317161 61317400 239 0
p130 shRbSenescentGSE19898 61315902 61317803 1901 0
p130 G0GSE7516 61316151 61317472 1321 0
p130 SGSE7516 61316222 61317448 1226 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-24 hsa-mir-24-1 9 19748357
hsa-miR-24 hsa-mir-24-2 19 19748357
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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