Annotation Detail for FGF2

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Basic Information Top

Gene Symbol:	FGF2 ( BFGF,FGFB,HBGF-2 )
Gene Full Name:	fibroblast growth factor 2 (basic)
Band:	4q28.1
Quick Links	Entrez ID:2247; OMIM: 134920; Uniprot ID:FGF2_HUMAN; ENSEMBL ID: ENSG00000138685; HGNC ID: 3676
Relate to Another Database:	SFARIGene; denovo-db

Post Translation Modification

Location(AA)	Modification
181	Cell attachment site; atypical
223	Cell attachment site; atypical

Location(AA)	Modifications	Resource
73	Phosphoserine (PKC alpha)	Phospho.ELM 6.0
121	Phosphothreonine (PKA

Location(AA)	Modification	Resource
112	Phosphotyrosine(Syk)	HMM predict
114	Phosphothreonine(PKC)	HMM predict

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Myc	K562	GSE19551	123953552	123953728	176	13673
P300	T30-glioblastoma	GSE21026	123960353	123961023	670	6625

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length
CTCF	G2	GSE9613	123967219	123968332	1113
H3K27me3	colorectal	cancer	123968915	123969298	383
H3K27me3	colorectal	cancer	123969536	123969813	277
Jun	K562	GSE19551	124014873	124015225	352
NFkBII	GM12878	GSE19485	123967770	123970027	2257
NFkBII	GM12892	GSE19485	123967325	123970051	2726
NFkBII	GM15510	GSE19485	123967626	123969592	1966
Oct1	H2O2-Hela	GSE14283	123982627	123982659	32
Oct1	Hela	GSE14283	123970313	123970360	47
Oct1	Hela	GSE14283	123970865	123970909	44
Oct4	hES	GSE21916	123967949	123969332	1383
P300	T30-glioblastoma	GSE21026	124014111	124015442	1331
TAF	Hela	GSE8489	123968332	123968581	249
hScc1	Bcell	GSE12603	123967186	123968488	1302
hScc1	G2	GSE9613	123967081	123968581	1500

Validated miRNA targets

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-let-7b	hsa-let-7b	22	18668040
hsa-let-7b*	hsa-let-7b	22	18668040
hsa-miR-1	hsa-mir-1-2	18	18668040
hsa-miR-1	hsa-mir-1-1	20	18668040
hsa-miR-146a	hsa-mir-146a	5	20641033
hsa-miR-146a*	hsa-mir-146a	5	20641033
hsa-miR-146b-3p	hsa-mir-146b	10	20641033
hsa-miR-146b-5p	hsa-mir-146b	10	20641033
hsa-miR-155	hsa-mir-155	21	18668040
hsa-miR-155*	hsa-mir-155	21	18668040
hsa-miR-16	hsa-mir-16-1	13	18668040
hsa-miR-16	hsa-mir-16-2	3	18668040
hsa-miR-30a	hsa-mir-30a	6	18668040
hsa-miR-30a*	hsa-mir-30a	6	18668040
hsa-miR-30b	hsa-mir-30b	8	18668040
hsa-miR-30b*	hsa-mir-30b	8	18668040
hsa-miR-30c	hsa-mir-30c-2	6	18668040
hsa-miR-30c	hsa-mir-30c-1	1	18668040
hsa-miR-30c-1*	hsa-mir-30c-1	1	18668040
hsa-miR-30c-2*	hsa-mir-30c-2	6	18668040
hsa-miR-30d	hsa-mir-30d	8	18668040
hsa-miR-30d*	hsa-mir-30d	8	18668040
hsa-miR-30e	hsa-mir-30e	1	18668040
hsa-miR-30e*	hsa-mir-30e	1	18668040

ID in Tarbase	Data Type	Support Type	miRNA	Gene	Direct Support	Publication
1040	Unknown	pSILAC	miR-16	FGF2	down 75-50%	18668040
Ensembl	Protein Type	Differentially expressed in	Pathology or Event	Mis Regulation	Gene Expression	Tumour Involvement
ENSG00000138685		n_a	n_a	n_a	"squamous cell, lymphocyte, muscle cell"	"benign tumour, malignant tumour, carcinoma, sarcoma"

Cis-Nats regulation

Cluster ID	Plue Type	Plus Gene Name	Plus Chromosome	Plus Start	Plus End	Overlap Length	Minus Type	Minus Gene Name	Minus Chromosome	Minus Star	Minus End	Type
20164	mRNA	FGF2	chr4	124105467	124176995	636	mRNA	NUDT6	chr4	124171404	124201364	Sense/Antisense (SA) pairs

Simple Query:

Paper Collected: 6/30/2018

Last Update: 8/26/2018