AutismKB 2.0

Annotation Detail for FHIT


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Basic Information Top
Gene Symbol:FHIT ( AP3Aase,FRA3B )
Gene Full Name: fragile histidine triad gene
Band: 3p14.2
Quick LinksEntrez ID:2272; OMIM: 601153; Uniprot ID:FHIT_HUMAN; ENSEMBL ID: ENSG00000189283; HGNC ID: 3701
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
98Histidine triad motif.
114Phosphotyrosine; by SRC.
145Phosphotyrosine.
Location(AA) Modifications Resource
113PhosphotyrosinePhospho.ELM 6.0
114Phosphotyrosine (by SRC).Swiss-Prot 53.0
145Phosphotyrosine.Swiss-Prot 53.0
Location(AA) Modification Resource
67Phosphothreonine(PKC)HMM predict
91Phosphothreonine(PKC)HMM predict
114Phosphotyrosine(EGFR)HMM predict
114Phosphotyrosine(INSR)HMM predict
114Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002012
  • Location:chr3 59710077-61212163
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 61211846 61212754 908 137
Fos K562GSE19551 61211931 61212511 580 58
H3K4me3 colorectalcancer 61212239 61212824 585 368
H3ac HepG2E 61212166 61213148 982 494
LIN9 G0GSE7516 61212135 61212549 414 179
P300 T0-glioblastomaGSE21026 61211997 61212756 759 213
P300 T30-glioblastomaGSE21026 61211976 61212718 742 184
Rb GrowingGSE19898 61212110 61212461 351 122
Rb QuiescentGSE19898 61211980 61212420 440 37
Rb SenescentGSE19898 61212108 61212604 496 193
Rb shRbQuiescentGSE19898 61212126 61212281 155 40
Rb shRbSenescenceGSE19898 61212214 61212422 208 155
p130 QuiescentGSE19898 61212133 61212467 334 137
p130 SenescentGSE19898 61211987 61212672 685 166
p130 shRbQuiescentGSE19898 61212063 61212691 628 214
p130 shRbSenescentGSE19898 61212017 61212493 476 92
p130 G0GSE7516 61212166 61212620 454 230
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 59709211 59709240 29 852
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 60027197 60027515 318 0
CBP T0-glioblastomaGSE21026 60255030 60255381 351 0
CBP T30-glioblastomaGSE21026 60703134 60703971 837 0
CTCF CD4GSE12889 59818488 59818953 465 0
CTCF CD4SISSRdata 59818488 59818953 465 0
CTCF G2GSE9613 59721484 59721794 310 0
CTCF G2GSE9613 59818491 59818904 413 0
CTCF G2GSE9613 59847610 59847948 338 0
CTCF G2GSE9613 60194062 60194379 317 0
CTCF G2GSE9613 60475735 60476060 325 0
CTCF G2GSE9613 60482699 60482854 155 0
CTCF G2GSE9613 60521537 60521827 290 0
CTCF G2GSE9613 60574145 60574285 140 0
CTCF G2GSE9613 60693241 60693432 191 0
CTCF G2GSE9613 60893529 60893707 178 0
CTCF G2GSE9613 61211757 61212202 445 0
ER E2-MCF7GSE14664 60035424 60035486 62 0
ER E2-MCF7GSE14664 60038062 60038106 44 0
ER Fulvestrant-MCF7GSE14664 59899590 59899629 39 0
ER Fulvestrant-MCF7GSE14664 60038062 60038108 46 0
ER Fulvestrant-MCF7GSE14664 60244611 60244646 35 0
ER Fulvestrant-MCF7GSE14664 60811091 60811133 42 0
ER Fulvestrant-MCF7GSE14664 61066745 61066787 42 0
ER Fulvestrant-MCF7GSE14664 61082675 61082709 34 0
FOXA1 MCF7GSE15244 60731333 60731480 147 0
FOXA1 MCF7GSE15244 60789720 60790441 721 0
FOXA1 MCF7GSE15244 60801912 60802578 666 0
FOXA1 MCF7GSE15244 61017985 61018639 654 0
FOXA1 MCF7GSE15244 61025268 61026432 1164 0
Fos K562GSE19551 59823409 59823893 484 0
Fos K562GSE19551 60014389 60014649 260 0
Fos K562GSE19551 60047473 60048047 574 0
FoxA1 MCF7MACSdata 60802115 60802420 305 0
Gata2 K562GSE18868 59837979 59838398 419 0
H3K4me2 HCT116GSE10453 61210974 61211568 594 0
H3K4me3 colorectalcancer 61210974 61211667 693 0
H3ac HepG2E 61210974 61211711 737 0
Jun K562GSE19551 59823408 59823812 404 0
KLF4 hESGSE17917 60512175 60512381 206 0
KLF4 hESGSE17917 60589827 60589983 156 0
Myc K562GSE19551 59804556 59804875 319 0
Myc K562GSE19551 59838063 59838311 248 0
Myc K562GSE19551 60237963 60238685 722 0
Myc hESGSE17917 60566739 60567050 311 0
NRSF-mono JurkatQuESTdata 60397113 60397463 350 0
Nanog ESGSE20650 60201283 60201745 462 0
Nanog hESGSE18292 60371140 60371750 610 0
Nanog hESGSE18292 60532364 60532746 382 0
Nanog hESGSE18292 60570401 60570669 268 0
Nanog hESGSE18292 60576477 60576731 254 0
Nanog hESGSE18292 60630348 60630968 620 0
Nanog hESGSE18292 60793118 60793530 412 0
Nanog hESGSE18292 60847173 60847553 380 0
Nanog hESGSE18292 61000636 61000902 266 0
Nanog hESGSE18292 61202360 61202642 282 0
Oct1 H2O2-HelaGSE14283 59793322 59793359 37 0
Oct1 H2O2-HelaGSE14283 59878557 59878584 27 0
Oct1 H2O2-HelaGSE14283 59916836 59916874 38 0
Oct1 H2O2-HelaGSE14283 60038067 60038108 41 0
Oct1 H2O2-HelaGSE14283 60241129 60241157 28 0
Oct1 H2O2-HelaGSE14283 60256076 60256103 27 0
Oct1 H2O2-HelaGSE14283 60462354 60462395 41 0
Oct1 H2O2-HelaGSE14283 60699773 60699807 34 0
Oct1 H2O2-HelaGSE14283 60745737 60745770 33 0
Oct1 H2O2-HelaGSE14283 60783023 60783052 29 0
Oct1 H2O2-HelaGSE14283 60799987 60800028 41 0
Oct1 H2O2-HelaGSE14283 60825986 60826034 48 0
Oct1 H2O2-HelaGSE14283 60973047 60973090 43 0
Oct1 H2O2-HelaGSE14283 61148442 61148473 31 0
Oct1 HelaGSE14283 59739408 59739447 39 0
Oct1 HelaGSE14283 59793322 59793358 36 0
Oct1 HelaGSE14283 59900028 59900107 79 0
Oct1 HelaGSE14283 59916836 59916874 38 0
Oct1 HelaGSE14283 59978100 59978139 39 0
Oct1 HelaGSE14283 60035445 60035486 41 0
Oct1 HelaGSE14283 60038068 60038107 39 0
Oct1 HelaGSE14283 60060780 60060807 27 0
Oct1 HelaGSE14283 60121448 60121479 31 0
Oct1 HelaGSE14283 60122131 60122163 32 0
Oct1 HelaGSE14283 60241123 60241158 35 0
Oct1 HelaGSE14283 60387611 60387655 44 0
Oct1 HelaGSE14283 60462367 60462395 28 0
Oct1 HelaGSE14283 60745738 60745766 28 0
Oct1 HelaGSE14283 60783023 60783052 29 0
Oct1 HelaGSE14283 60799983 60800029 46 0
Oct1 HelaGSE14283 60825987 60826026 39 0
Oct1 HelaGSE14283 60973045 60973092 47 0
Oct1 HelaGSE14283 61066751 61066784 33 0
Oct1 HelaGSE14283 61078446 61078481 35 0
Oct1 HelaGSE14283 61082654 61082710 56 0
Oct1 HelaGSE14283 61110935 61110969 34 0
Oct4 ESGSE20650 60660857 60660944 87 0
Oct4 hESGSE17917 60512189 60512376 187 0
P300 T0-glioblastomaGSE21026 60770294 60771252 958 0
P300 T0-glioblastomaGSE21026 60801857 60802794 937 0
P300 T30-glioblastomaGSE21026 59726583 59727538 955 0
P300 T30-glioblastomaGSE21026 60025391 60026267 876 0
P300 T30-glioblastomaGSE21026 60261863 60262452 589 0
P300 T30-glioblastomaGSE21026 60702971 60704045 1074 0
P300 T30-glioblastomaGSE21026 60770331 60771174 843 0
P300 T30-glioblastomaGSE21026 60802056 60802652 596 0
PAX3-FKHR Rh4GSE19063 60259286 60260518 1232 0
RARA MCF7GSE15244 60560379 60560839 460 0
RARA MCF7GSE15244 61017942 61018639 697 0
RARA MCF7GSE15244 61025268 61026432 1164 0
RARA MCF7GSE15244 61211085 61211604 519 0
RNAII Tamoxifen-MCF7GSE14664 60978068 60978133 65 0
STAT1 IFNSISSRdata 59818487 59818860 373 0
Sox2 hESGSE18292 60630443 60630772 329 0
Sox2 hESGSE18292 61000627 61000843 216 0
Sox2 hESGSE18292 61066654 61066931 277 0
Sox2 hESGSE18292 61202216 61202586 370 0
Stat6 IL-4-hr4GSE17850 61194603 61195143 540 0
TAF k562GSE8489 60237071 60237348 277 0
TAF k562GSE8489 60237804 60237981 177 0
TFAP2C MCF7GSE21234 60635678 60636075 397 0
TFAP2C MCF7GSE21234 60703417 60703951 534 0
TFAP2C MCF7GSE21234 60704504 60704980 476 0
TFAP2C MCF7GSE21234 60731391 60731835 444 0
TFAP2C MCF7GSE21234 60736601 60737111 510 0
TFAP2C MCF7GSE21234 60770391 60770932 541 0
TFAP2C MCF7GSE21234 60873666 60873970 304 0
TFAP2C MCF7GSE21234 61025992 61026438 446 0
TFAP2C MCF7GSE21234 61210561 61211344 783 0
TFAP2C MCF7GSE21234 61211411 61211747 336 0
USF1 HepG2E 61210441 61212013 1572 0
USF2 HepG2E 61211010 61211640 630 0
hScc1 BcellGSE12603 59792305 59792586 281 0
hScc1 BcellGSE12603 59818491 59818972 481 0
hScc1 BcellGSE12603 60594407 60594726 319 0
hScc1 BcellGSE12603 61210719 61210974 255 0
hScc1 CdLSGSE12603 59818452 59818972 520 0
hScc1 CdLSGSE12603 59886172 59886350 178 0
hScc1 G2GSE9613 59818277 59818941 664 0
p63 keratinocytesGSE17611 60554672 60555517 845 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-125b hsa-mir-125b-1 11 20306291
hsa-miR-125b-1* hsa-mir-125b-1 11 20306291
hsa-miR-29a hsa-mir-29a 7 17890317
hsa-miR-29a* hsa-mir-29a 7 17890317
hsa-miR-29b hsa-mir-29b-1 7 17890317
hsa-miR-29b hsa-mir-29b-2 1 17890317
hsa-miR-29b-1* hsa-mir-29b-1 7 17890317
hsa-miR-29b-2* hsa-mir-29b-2 1 17890317
hsa-miR-29c hsa-mir-29c 1 17890317
hsa-miR-29c* hsa-mir-29c 1 17890317
hsa-miR-646 hsa-mir-646 20 20306291
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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