AutismKB 2.0

Annotation Detail for XRN2


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Basic Information Top
Gene Symbol:XRN2 ( - )
Gene Full Name: 5'-3' exoribonuclease 2
Band: 20p11.22
Quick LinksEntrez ID:22803; OMIM: 608851; Uniprot ID:XRN2_HUMAN; ENSEMBL ID: ENSG00000088930; HGNC ID: 12836
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
439Phosphothreonine.
448Phosphoserine.
455Phosphoserine.
471Phosphoserine.
473Phosphoserine.
475Phosphoserine.
499Phosphoserine.
501Phosphoserine.
796N6-acetyllysine.
Location(AA) Modifications Resource
448Phosphoserine.Swiss-Prot 53.0
448PhosphoserinePhospho.ELM 6.0
455Phosphoserine.Swiss-Prot 53.0
499Phosphoserine.Swiss-Prot 53.0
499PhosphoserinePhospho.ELM 6.0
501Phosphoserine.Swiss-Prot 53.0
501PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
39Phosphoserine(IKK)HMM predict
122Phosphoserine(PKG)HMM predict
157Phosphoserine(IKK)HMM predict
190N-linkedHMM predict
247N-linkedHMM predict
377Phosphotyrosine(INSR)HMM predict
383Phosphotyrosine(INSR)HMM predict
435O-linkedHMM predict
445O-linkedHMM predict
448Phosphoserine(MAPK)HMM predict
451Phosphoserine(IKK)HMM predict
451Phosphoserine(ATM)HMM predict
468N-linkedHMM predict
469N-linkedHMM predict
471Phosphoserine(CDC2)HMM predict
471Phosphoserine(ATM)HMM predict
471Phosphoserine(CDK)HMM predict
473O-linkedHMM predict
475Phosphoserine(ATM)HMM predict
477N-linkedHMM predict
478O-linkedHMM predict
485PhosphoserineHMM predict
487Phosphoserine(CDK)HMM predict
487Phosphoserine(CDC2)HMM predict
501Phosphoserine(ATM)HMM predict
501Phosphoserine(IKK)HMM predict
501Phosphoserine(CK1)HMM predict
521Phosphotyrosine(Jak)HMM predict
666Phosphotyrosine(Syk)HMM predict
670Phosphothreonine(MAPK)HMM predict
678Phosphoserine(PKG)HMM predict
737Phosphoserine(CDC2)HMM predict
831Phosphotyrosine(INSR)HMM predict
925MethylarginineHMM predict
937LysineHMM predict
947TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_012255
  • Location:chr20 21231941-21318462
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3K4me3 colorectalcancer 21231295 21231621 326 484
H3ac HepG2E 21230597 21231684 1087 801
KLF4 hESGSE17917 21231654 21232017 363 106
PHF8 HeLaGSE20725 21231187 21232667 1480 15
Rb SenescentGSE19898 21219726 21220076 350 12041
USF1 HepG2E 21230597 21231759 1162 764
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 21325077 21325730 653 6941
hScc1 BcellGSE12603 21320198 21320609 411 1941
hScc1 BcellGSE12603 21324702 21325730 1028 6754
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ETS1 JurkatGSE17954 21231350 21232845 1495 0
H3K4me3 colorectalcancer 21232339 21233400 1061 0
H3ac HepG2E 21232385 21233680 1295 0
KLF4 hESGSE17917 21243505 21243865 360 0
Myc K562GSE19551 21231615 21232646 1031 0
Oct4 hESGSE17917 21231842 21232120 278 0
PHF8 Hs68minusFBSGSE20725 21231447 21232883 1436 0
Rb GrowingGSE19898 21252837 21253038 201 0
Rb QuiescentGSE19898 21232264 21232533 269 0
Rb QuiescentGSE19898 21252787 21253082 295 0
Rb SenescentGSE19898 21232108 21232608 500 0
Rb shRbSenescenceGSE19898 21232224 21232660 436 0
TFAP2C MCF7GSE21234 21231815 21232085 270 0
USF1 HepG2E 21232421 21233572 1151 0
USF2 HepG2E 21232490 21233126 636 0
hScc1 BcellGSE12603 21231621 21232267 646 0
p130 QuiescentGSE19898 21232249 21232668 419 0
p130 SenescentGSE19898 21232235 21232578 343 0
p130 shRbQuiescentGSE19898 21231906 21232797 891 0
p130 shRbSenescentGSE19898 21231768 21232657 889 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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