AutismKB 2.0

Annotation Detail for LMTK2


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Basic Information Top
Gene Symbol:LMTK2 ( AATYK2,BREK,FLJ46659,KIAA1079,KPI-2,KPI2,LMR2,cprk )
Gene Full Name: lemur tyrosine kinase 2
Band: 7q21.3
Quick LinksEntrez ID:22853; OMIM: 610989; Uniprot ID:LMTK2_HUMAN; ENSEMBL ID: ENSG00000164715; HGNC ID: 17880
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
112N-linked (GlcNAc...) (Potential).
352N-linked (GlcNAc...) (Potential).
544N-linked (GlcNAc...) (Potential).
786N-linked (GlcNAc...) (Potential).
881N-linked (GlcNAc...) (Potential).
955Phosphoserine.
1109N-linked (GlcNAc...) (Potential).
1170N-linked (GlcNAc...) (Potential).
1305Phosphoserine.
1307Phosphoserine.
1308Phosphoserine.
1310Phosphoserine.
Location(AA) Modifications Resource
112N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
352N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
544N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
786N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
881N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1109N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1170N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1305Phosphoserine.Swiss-Prot 53.0
1307Phosphoserine.Swiss-Prot 53.0
1308Phosphoserine.Swiss-Prot 53.0
1310Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
96Phosphothreonine(MAPK)HMM predict
98Phosphoserine(IKK)HMM predict
98Phosphoserine(ATM)HMM predict
98O-linkedHMM predict
101Phosphoserine(CDK)HMM predict
101Phosphoserine(CDC2)HMM predict
119Phosphoserine(ATM)HMM predict
139Phosphotyrosine(INSR)HMM predict
295SulfotyrosineHMM predict
295Phosphotyrosine(INSR)HMM predict
295Phosphotyrosine(Syk)HMM predict
351Phosphoserine(IKK)HMM predict
408Phosphothreonine(PKC)HMM predict
476SulfotyrosineHMM predict
515Phosphoserine(CK1)HMM predict
515Phosphoserine(ATM)HMM predict
552Phosphotyrosine(EGFR)HMM predict
552SulfotyrosineHMM predict
552Phosphotyrosine(INSR)HMM predict
587Phosphoserine(ATM)HMM predict
600Phosphoserine(CK1)HMM predict
601Phosphoserine(CK2)HMM predict
601Phosphoserine(CK1)HMM predict
617Phosphoserine(IKK)HMM predict
625O-linkedHMM predict
630Phosphoserine(CDC2)HMM predict
737Phosphoserine(CK2)HMM predict
786N-linkedHMM predict
825Phosphothreonine(MAPK)HMM predict
825Phosphothreonine(CDC2)HMM predict
878Phosphoserine(PKA)HMM predict
878Phosphoserine(CAMK2)HMM predict
881N-linkedHMM predict
883Phosphoserine(ATM)HMM predict
886Phosphoserine(IKK)HMM predict
913Phosphoserine(CAMK2)HMM predict
972Phosphoserine(CK1)HMM predict
974Phosphoserine(ATM)HMM predict
974Phosphoserine(CK1)HMM predict
974Phosphoserine(IKK)HMM predict
977Phosphoserine(CK2)HMM predict
993Phosphoserine(CK1)HMM predict
993O-linkedHMM predict
996Phosphothreonine(CDK)HMM predict
999Phosphoserine(IKK)HMM predict
1002PhosphoserineHMM predict
1032Phosphotyrosine(INSR)HMM predict
1032Phosphotyrosine(Syk)HMM predict
1065O-linkedHMM predict
1085Phosphothreonine(PKA)HMM predict
1088Phosphothreonine(MAPK)HMM predict
1107Phosphoserine(ATM)HMM predict
1109N-linkedHMM predict
1111Phosphoserine(CK2)HMM predict
1111Phosphoserine(CK1)HMM predict
1158Phosphoserine(PKG)HMM predict
1158Phosphoserine(ATM)HMM predict
1166Phosphoserine(CK1)HMM predict
1170N-linkedHMM predict
1199Phosphoserine(CK1)HMM predict
1203Phosphoserine(IKK)HMM predict
1248Phosphoserine(CK1)HMM predict
1248Phosphoserine(CK2)HMM predict
1291Phosphoserine(CK1)HMM predict
1291Phosphoserine(CK2)HMM predict
1294PhosphoserineHMM predict
1294Phosphoserine(CK1)HMM predict
1307Phosphoserine(CK2)HMM predict
1307Phosphoserine(CK1)HMM predict
1308Phosphoserine(CK1)HMM predict
1308Phosphoserine(CK2)HMM predict
1310Phosphoserine(CK2)HMM predict
1389O-linkedHMM predict
1389Phosphoserine(ATM)HMM predict
1395O-linkedHMM predict
1408Phosphoserine(CK2)HMM predict
1409Phosphoserine(CK2)HMM predict
1409Phosphoserine(CK1)HMM predict
1410Phosphothreonine(CK2)HMM predict
1424Phosphoserine(ATM)HMM predict
1434Phosphoserine(IKK)HMM predict
1450O-linkedHMM predict
1450Phosphoserine(ATM)HMM predict
1450Phosphoserine(CDC2)HMM predict
1458O-linkedHMM predict
1461Phosphoserine(IKK)HMM predict
1474Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014916
  • Location:chr7 97574132-97673536
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 97573802 97574177 375 143
CTCF CD4SISSRdata 97573802 97574177 375 143
CTCF G2GSE9613 97573372 97574739 1367 77
ETS1 JurkatGSE17954 97573652 97574573 921 20
Fos K562GSE19551 97573594 97574385 791 143
Oct1 HelaGSE14283 97556627 97556656 29 17491
P300 T0-glioblastomaGSE21026 97573679 97574529 850 29
P300 T30-glioblastomaGSE21026 97573565 97574606 1041 47
RNAII Tamoxifen-MCF7GSE14664 97561456 97561547 91 12631
Rb SenescentGSE19898 97573863 97574356 493 23
USF1 HepG2E 97572981 97573336 355 974
hScc1 BcellGSE12603 97573610 97574453 843 101
hScc1 CdLSGSE12603 97573299 97574553 1254 207
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 97632916 97633614 698 0
CTCF G2GSE9613 97634494 97634843 349 0
CTCF G2GSE9613 97635232 97636236 1004 0
CTCF G2GSE9613 97657898 97658270 372 0
CTCF G2GSE9613 97672582 97673094 512 0
ER E2-MCF7GSE14664 97642796 97642833 37 0
ER Fulvestrant-MCF7GSE14664 97627184 97627225 41 0
ER Fulvestrant-MCF7GSE14664 97642799 97642836 37 0
Fos K562GSE19551 97635817 97636280 463 0
FoxA1 MCF7MACSdata 97586508 97586740 232 0
NFkBII GM10847GSE19485 97669127 97671425 2298 0
Oct1 H2O2-HelaGSE14283 97575000 97575031 31 0
Oct1 H2O2-HelaGSE14283 97596712 97596744 32 0
Oct1 H2O2-HelaGSE14283 97611791 97611818 27 0
Oct1 H2O2-HelaGSE14283 97639129 97639161 32 0
Oct1 H2O2-HelaGSE14283 97642805 97642833 28 0
Oct1 H2O2-HelaGSE14283 97648853 97648882 29 0
Oct1 H2O2-HelaGSE14283 97672942 97672969 27 0
Oct1 HelaGSE14283 97596712 97596754 42 0
Oct1 HelaGSE14283 97611787 97611826 39 0
Oct1 HelaGSE14283 97627154 97627234 80 0
Oct1 HelaGSE14283 97642793 97642834 41 0
Oct1 HelaGSE14283 97667067 97667099 32 0
PHF8 293TGSE20725 97573906 97574574 668 0
PHF8 HeLaGSE20725 97573721 97574832 1111 0
PHF8 Hs68plusFBSGSE20725 97573720 97574734 1014 0
RNAII Tamoxifen-MCF7GSE14664 97632881 97632966 85 0
RNAII Tamoxifen-MCF7GSE14664 97667062 97667100 38 0
Rb GrowingGSE19898 97578386 97578615 229 0
Rb QuiescentGSE19898 97647824 97647962 138 0
STAT1 HeLaGSE12783 97598575 97599803 1228 0
TAF HelaGSE8489 97642764 97643058 294 0
TFAP2C MCF7GSE21234 97633843 97634181 338 0
TFAP2C MCF7GSE21234 97646285 97646728 443 0
hScc1 BcellGSE12603 97633264 97633614 350 0
hScc1 CdLSGSE12603 97635757 97636271 514 0
hScc1 CdLSGSE12603 97638771 97639081 310 0
hScc1 G2GSE9613 97573651 97575036 1385 0
hScc1 G2GSE9613 97635757 97636271 514 0
p130 shRbQuiescentGSE19898 97584260 97584769 509 0
p130 shRbSenescentGSE19898 97574000 97574411 411 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
24351 mRNA LMTK2 chr7 97380847 97480252 3214 mRNA chr7 97397251 97400465 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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