AutismKB 2.0

Annotation Detail for CNKSR2


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Basic Information Top
Gene Symbol:CNKSR2 ( CNK2,KIAA0902,KSR2,MAGUIN )
Gene Full Name: connector enhancer of kinase suppressor of Ras 2
Band: Xp22.12
Quick LinksEntrez ID:22866; OMIM: 300724; Uniprot ID:CNKR2_HUMAN; ENSEMBL ID: ENSG00000149970; HGNC ID: 19701
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
248Phosphoserine (By similarity).
325Phosphoserine (By similarity).
390Phosphoserine (By similarity).
467Phosphoserine (By similarity).
846Phosphothreonine (By similarity).
908Phosphoserine.
Location(AA) Modifications Resource
248Phosphoserine (By similarity).Swiss-Prot 53.0
325Phosphoserine (By similarity).Swiss-Prot 53.0
390Phosphoserine (By similarity).Swiss-Prot 53.0
467Phosphoserine (By similarity).Swiss-Prot 53.0
846Phosphothreonine (By similarity).Swiss-Prot 53.0
908Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
87Phosphothreonine(PKC)HMM predict
145Phosphoserine(CDK)HMM predict
156O-linkedHMM predict
208Phosphoserine(ATM)HMM predict
292Phosphothreonine(PKC)HMM predict
299Phosphoserine(IKK)HMM predict
325Phosphoserine(CDC2)HMM predict
328O-linkedHMM predict
328O-linkedHMM predict
328Phosphoserine(IKK)HMM predict
329O-linkedHMM predict
332Phosphothreonine(MAPK)HMM predict
332O-linkedHMM predict
332O-linkedHMM predict
332Phosphothreonine(CDK)HMM predict
334O-linkedHMM predict
335O-linkedHMM predict
335O-linkedHMM predict
336O-linkedHMM predict
339Phosphothreonine(CDK)HMM predict
339Phosphothreonine(MAPK)HMM predict
390Phosphoserine(ATM)HMM predict
393Phosphoserine(IKK)HMM predict
399Phosphotyrosine(Syk)HMM predict
424Phosphoserine(ATM)HMM predict
430Phosphoserine(PKG)HMM predict
430PhosphoserineHMM predict
430Phosphoserine(PKA)HMM predict
430Phosphoserine(PKC)HMM predict
431Phosphothreonine(PKA)HMM predict
431Phosphothreonine(PKG)HMM predict
434Phosphotyrosine(SRC)HMM predict
467Phosphoserine(PKG)HMM predict
471Phosphotyrosine(INSR)HMM predict
492Phosphothreonine(PKC)HMM predict
496Phosphoserine(PKG)HMM predict
503Phosphoserine(IKK)HMM predict
564Phosphoserine(PKG)HMM predict
588Phosphoserine(ATM)HMM predict
697Phosphothreonine(MAPK)HMM predict
697Phosphothreonine(CDK)HMM predict
697Phosphothreonine(CDC2)HMM predict
702Phosphoserine(IKK)HMM predict
717Phosphoserine(IKK)HMM predict
731Phosphoserine(CK1)HMM predict
732Phosphoserine(CK1)HMM predict
736O-linkedHMM predict
736Phosphoserine(ATM)HMM predict
736Phosphoserine(IKK)HMM predict
736Phosphoserine(CK1)HMM predict
738Phosphoserine(IKK)HMM predict
738Phosphoserine(ATM)HMM predict
756Phosphoserine(CDC2)HMM predict
756Phosphoserine(CDK)HMM predict
774Phosphothreonine(CDK)HMM predict
795Phosphoserine(CK1)HMM predict
808Phosphoserine(PKG)HMM predict
809Phosphothreonine(PKA)HMM predict
844Phosphoserine(IKK)HMM predict
900PhosphoserineHMM predict
900Phosphoserine(CK2)HMM predict
913Phosphotyrosine(Jak)HMM predict
922Phosphoserine(MAPK)HMM predict
922Phosphoserine(CDC2)HMM predict
931Phosphothreonine(PKC)HMM predict
1003N-linkedHMM predict
1007N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014927
  • Location:chrX 21302900-21580699
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 21302080 21302329 249 696
hScc1 BcellGSE12603 21301709 21303255 1546 419
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 21423824 21424267 443 0
CTCF G2GSE9613 21302901 21303255 354 0
ER Fulvestrant-MCF7GSE14664 21465402 21465441 39 0
ER Fulvestrant-MCF7GSE14664 21533743 21533776 33 0
H3K27me3 colorectalcancer 21303658 21304248 590 0
Nanog ESGSE20650 21322827 21323311 484 0
Nanog hESGSE18292 21322708 21323333 625 0
Oct1 H2O2-HelaGSE14283 21318897 21318926 29 0
Oct1 H2O2-HelaGSE14283 21327403 21327446 43 0
Oct1 H2O2-HelaGSE14283 21465404 21465435 31 0
Oct1 HelaGSE14283 21318897 21318926 29 0
Oct1 HelaGSE14283 21465405 21465436 31 0
Oct1 HelaGSE14283 21533740 21533771 31 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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