AutismKB 2.0

Annotation Detail for NLGN1


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Basic Information Top
Gene Symbol:NLGN1 ( KIAA1070,MGC45115,NL1 )
Gene Full Name: neuroligin 1
Band: 3q26.31
Quick LinksEntrez ID:22871; OMIM: 600568; Uniprot ID:NLGN1_HUMAN; ENSEMBL ID: ENSG00000169760; HGNC ID: 14291
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
109N-linked (GlcNAc...) (complex) (By
300N-linked (GlcNAc...) (complex) (By
340N-linked (GlcNAc...) (complex) (By
544N-linked (GlcNAc...) (By similarity).
680O-linked (GalNAc...) (By similarity).
683O-linked (GalNAc...) (By similarity).
Location(AA) Modifications Resource
109N-linked (GlcNAc...) (complex) (Bysimilarity).Swiss-Prot 53.0
300N-linked (GlcNAc...) (complex) (Bysimilarity).Swiss-Prot 53.0
340N-linked (GlcNAc...) (complex) (Bysimilarity).Swiss-Prot 53.0
544N-linked (GlcNAc...) (By similarity).Swiss-Prot 53.0
680O-linked (GalNAc...) (By similarity).Swiss-Prot 53.0
683O-linked (GalNAc...) (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
85Phosphotyrosine(Abl)HMM predict
102Phosphoserine(MAPK)HMM predict
109N-linkedHMM predict
155Phosphotyrosine(Syk)HMM predict
159Phosphotyrosine(INSR)HMM predict
300N-linkedHMM predict
340N-linkedHMM predict
440Phosphotyrosine(Abl)HMM predict
468Phosphothreonine(PKC)HMM predict
472Phosphothreonine(PKA)HMM predict
637Phosphoserine(ATM)HMM predict
640O-linkedHMM predict
641O-linkedHMM predict
643O-linkedHMM predict
660Phosphoserine(PKG)HMM predict
660Phosphoserine(PKA)HMM predict
664O-linkedHMM predict
690Phosphoserine(CK1)HMM predict
696O-linkedHMM predict
822N-linkedHMM predict
823N-linkedHMM predict
832ProlineHMM predict
836Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014932
  • Location:chr3 174598937-175483809
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 174595853 174596410 557 2806
CTCF G2GSE9613 174598147 174598536 389 596
H3K27me3 colorectalcancer 174596367 174598066 1699 1721
H3K27me3 colorectalcancer 174598404 174599222 818 125
H3K4me3 colorectalcancer 174597492 174597865 373 1259
Rb SenescentGSE19898 174595921 174596235 314 2860
p130 shRbQuiescentGSE19898 174595644 174596468 824 2882
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 174729628 174729844 216 0
CTCF G2GSE9613 174612295 174612434 139 0
CTCF G2GSE9613 174633635 174633830 195 0
CTCF G2GSE9613 174754113 174754400 287 0
CTCF G2GSE9613 174784758 174785195 437 0
CTCF G2GSE9613 174818986 174819259 273 0
CTCF G2GSE9613 174844862 174845424 562 0
CTCF G2GSE9613 174985456 174985636 180 0
CTCF G2GSE9613 175072522 175072739 217 0
CTCF G2GSE9613 175193859 175194083 224 0
CTCF G2GSE9613 175224232 175224448 216 0
CTCF G2GSE9613 175291027 175291596 569 0
CTCF G2GSE9613 175325850 175326389 539 0
FoxA1 MCF7MACSdata 175398717 175398973 256 0
H3K27me3 colorectalcancer 174785088 174785491 403 0
Nanog ESGSE20650 174899767 174900274 507 0
Nanog hESGSE18292 174754231 174754649 418 0
Nanog hESGSE18292 175163583 175163761 178 0
Nanog hESGSE18292 175211276 175211929 653 0
Oct4 hESGSE21916 175211231 175211840 609 0
Oct4 hESGSE21916 175433085 175433652 567 0
PAX3-FKHR Rh4GSE19063 175404453 175405889 1436 0
RARA MCF7GSE15244 175408639 175409350 711 0
TFAP2C MCF7GSE21234 174757060 174757348 288 0
TFAP2C MCF7GSE21234 174994410 174994942 532 0
USF1 HepG2E 175332956 175333626 670 0
USF2 HepG2E 175333024 175333752 728 0
hScc1 CdLSGSE12603 175325885 175326278 393 0
hScc1 G2GSE9613 174612101 174612503 402 0
hScc1 G2GSE9613 175193859 175194083 224 0
hScc1 G2GSE9613 175325850 175326389 539 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018