AutismKB 2.0

Annotation Detail for PLEKHA6


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Basic Information Top
Gene Symbol:PLEKHA6 ( KIAA0969,MGC176733,PEPP3 )
Gene Full Name: pleckstrin homology domain containing, family A member 6
Band: 1q32.1
Quick LinksEntrez ID:22874; OMIM: 607771; Uniprot ID:PKHA6_HUMAN; ENSEMBL ID: ENSG00000143850; HGNC ID: 17053
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
472Phosphoserine.
476Phosphoserine.
492Phosphotyrosine.
744Phosphothreonine (By similarity).
777Phosphoserine (By similarity).
801Phosphoserine (By similarity).
848Phosphoserine.
854Phosphoserine.
867Phosphoserine.
Location(AA) Modifications Resource
472Phosphoserine (By similarity).Swiss-Prot 53.0
476Phosphoserine (By similarity).Swiss-Prot 53.0
492Phosphotyrosine.Swiss-Prot 53.0
744Phosphothreonine (By similarity).Swiss-Prot 53.0
777Phosphoserine (By similarity).Swiss-Prot 53.0
848Phosphoserine.Swiss-Prot 53.0
854Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
99Phosphoserine(CK1)HMM predict
142PhosphoserineHMM predict
197Phosphoserine(CDK)HMM predict
247O-linkedHMM predict
247Phosphoserine(IKK)HMM predict
251O-linkedHMM predict
251Phosphoserine(CDC2)HMM predict
251PhosphoserineHMM predict
276Phosphoserine(CDC2)HMM predict
282O-linkedHMM predict
283O-linkedHMM predict
283O-linkedHMM predict
356Phosphoserine(ATM)HMM predict
362SulfotyrosineHMM predict
364Phosphotyrosine(Syk)HMM predict
373Phosphoserine(IKK)HMM predict
376Phosphoserine(MAPK)HMM predict
426Phosphoserine(CDC2)HMM predict
448Phosphoserine(PKA)HMM predict
448Phosphoserine(PKG)HMM predict
455Phosphoserine(CK1)HMM predict
455Phosphoserine(IKK)HMM predict
459Phosphoserine(CDC2)HMM predict
459Phosphoserine(CDK)HMM predict
459Phosphoserine(ATM)HMM predict
459Phosphoserine(IKK)HMM predict
461Phosphoserine(PKC)HMM predict
472Phosphoserine(CDK)HMM predict
476Phosphoserine(CDC2)HMM predict
478PhosphoserineHMM predict
492Phosphotyrosine(INSR)HMM predict
492Phosphotyrosine(SRC)HMM predict
492Phosphotyrosine(Jak)HMM predict
492Phosphotyrosine(Syk)HMM predict
492SulfotyrosineHMM predict
503Phosphoserine(PKG)HMM predict
505Phosphoserine(PKB)HMM predict
505PhosphoserineHMM predict
506Phosphoserine(CDC2)HMM predict
506Phosphoserine(MAPK)HMM predict
523Phosphotyrosine(INSR)HMM predict
530Phosphothreonine(CK2)HMM predict
560Phosphoserine(CK1)HMM predict
604Phosphoserine(ATM)HMM predict
604Phosphoserine(IKK)HMM predict
608O-linkedHMM predict
612N-linkedHMM predict
617SulfotyrosineHMM predict
666N-linkedHMM predict
685O-linkedHMM predict
687Phosphoserine(IKK)HMM predict
690O-linkedHMM predict
690Phosphoserine(CDC2)HMM predict
690Phosphoserine(IKK)HMM predict
693Phosphoserine(CDC2)HMM predict
693Phosphoserine(MAPK)HMM predict
693Phosphoserine(IKK)HMM predict
697O-linkedHMM predict
699O-linkedHMM predict
699Phosphoserine(IKK)HMM predict
701O-linkedHMM predict
702Phosphoserine(CDC2)HMM predict
702Phosphoserine(MAPK)HMM predict
702Phosphoserine(IKK)HMM predict
713Phosphoserine(ATM)HMM predict
713Phosphoserine(IKK)HMM predict
716Phosphoserine(CDC2)HMM predict
716Phosphoserine(CDK)HMM predict
716Phosphoserine(IKK)HMM predict
777Phosphoserine(CDC2)HMM predict
777Phosphoserine(IKK)HMM predict
784Phosphothreonine(MAPK)HMM predict
792N-linkedHMM predict
798N-linkedHMM predict
820Phosphoserine(PKG)HMM predict
848O-linkedHMM predict
848Phosphoserine(CDC2)HMM predict
848Phosphoserine(MAPK)HMM predict
848Phosphoserine(ATM)HMM predict
854O-linkedHMM predict
854Phosphoserine(CDK)HMM predict
854PhosphoserineHMM predict
867Phosphoserine(PKG)HMM predict
867Phosphoserine(PKB)HMM predict
890Phosphotyrosine(INSR)HMM predict
890Phosphotyrosine(Abl)HMM predict
890Phosphotyrosine(Jak)HMM predict
892Phosphothreonine(PKC)HMM predict
892Phosphothreonine(MAPK)HMM predict
892Phosphothreonine(CDK)HMM predict
940Phosphoserine(CDC2)HMM predict
940Phosphoserine(MAPK)HMM predict
956Phosphothreonine(PKC)HMM predict
983Phosphoserine(CK1)HMM predict
983Phosphoserine(ATM)HMM predict
1015O-linkedHMM predict
1015O-linkedHMM predict
1015Phosphothreonine(MAPK)HMM predict
1017O-linkedHMM predict
1020O-linkedHMM predict
1021O-linkedHMM predict
1021O-linkedHMM predict
1021Phosphoserine(CDC2)HMM predict
1021Phosphoserine(MAPK)HMM predict
1021Phosphoserine(CDK)HMM predict
1021Phosphoserine(ATM)HMM predict
1021Phosphoserine(IKK)HMM predict
1024O-linkedHMM predict
1024Phosphoserine(CDC2)HMM predict
1024Phosphoserine(MAPK)HMM predict
1024Phosphoserine(IKK)HMM predict
1036Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014935
  • Location:chr1 202454604-202595666
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 202599443 202599842 399 3976
CTCF CD4SISSRdata 202599443 202599842 399 3976
CTCF G2GSE9613 202595715 202595959 244 171
CTCF G2GSE9613 202597145 202597353 208 1583
CTCF G2GSE9613 202599421 202599991 570 4040
CTCF G2GSE9613 202602526 202603354 828 7274
CTCF G2GSE9613 202604320 202604456 136 8722
CTCF G2GSE9613 202613381 202613697 316 17873
FOXA1 MCF7GSE15244 202599138 202599991 853 3898
H3ac HepG2E 202609954 202611501 1547 15061
H3ac HepG2E 202614531 202615239 708 19219
RARA MCF7GSE15244 202599248 202599991 743 3953
hScc1 BcellGSE12603 202597145 202597391 246 1602
hScc1 BcellGSE12603 202598777 202599991 1214 3718
hScc1 BcellGSE12603 202602526 202603006 480 7100
hScc1 BcellGSE12603 202613337 202613697 360 17851
hScc1 CdLSGSE12603 202599248 202599991 743 3953
hScc1 G2GSE9613 202599421 202599991 570 4040
p130 QuiescentGSE19898 202599610 202599754 144 4016
p130 SenescentGSE19898 202599037 202599547 510 3626
p130 shRbQuiescentGSE19898 202599228 202599495 267 3695
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 202461232 202462265 1033 0
CBP T30-glioblastomaGSE21026 202489637 202490526 889 0
CBP T30-glioblastomaGSE21026 202529461 202530913 1452 0
CBP T30-glioblastomaGSE21026 202554799 202556835 2036 0
CTCF CD4GSE12889 202494243 202494455 212 0
CTCF CD4SISSRdata 202494243 202494455 212 0
CTCF HelaGSE12889 202494114 202494451 337 0
CTCF G2GSE9613 202458903 202459248 345 0
CTCF G2GSE9613 202461854 202462310 456 0
CTCF G2GSE9613 202463952 202464487 535 0
CTCF G2GSE9613 202478876 202479177 301 0
CTCF G2GSE9613 202493321 202493603 282 0
CTCF G2GSE9613 202494226 202494361 135 0
CTCF G2GSE9613 202494705 202495075 370 0
CTCF G2GSE9613 202497668 202497850 182 0
CTCF G2GSE9613 202500621 202500984 363 0
CTCF G2GSE9613 202511261 202511661 400 0
CTCF G2GSE9613 202531414 202531732 318 0
CTCF G2GSE9613 202532311 202532454 143 0
CTCF G2GSE9613 202553091 202553345 254 0
CTCF G2GSE9613 202567946 202568102 156 0
CTCF G2GSE9613 202588904 202589091 187 0
CTCF G2GSE9613 202593392 202594437 1045 0
FOXA1 MCF7GSE15244 202522575 202523474 899 0
FOXA1 MCF7GSE15244 202543058 202543814 756 0
H3ac HepG2E 202505162 202505564 402 0
Myc K562GSE19551 202556154 202556758 604 0
Nanog hESGSE18292 202490930 202491327 397 0
P300 T0-glioblastomaGSE21026 202529366 202530723 1357 0
P300 T0-glioblastomaGSE21026 202555015 202556582 1567 0
P300 T30-glioblastomaGSE21026 202461414 202462179 765 0
P300 T30-glioblastomaGSE21026 202529532 202530953 1421 0
P300 T30-glioblastomaGSE21026 202554406 202556671 2265 0
RARA MCF7GSE15244 202522612 202523790 1178 0
RARA MCF7GSE15244 202543021 202543780 759 0
RARA MCF7GSE15244 202549417 202550462 1045 0
RARA MCF7GSE15244 202564992 202565183 191 0
RARG MCF7GSE15244 202461430 202462416 986 0
Rb QuiescentGSE19898 202512143 202512282 139 0
TFAP2C MCF7GSE21234 202462102 202462626 524 0
TFAP2C MCF7GSE21234 202489772 202490354 582 0
TFAP2C MCF7GSE21234 202511609 202512714 1105 0
TFAP2C MCF7GSE21234 202523757 202524477 720 0
TFAP2C MCF7GSE21234 202529877 202530553 676 0
TFAP2C MCF7GSE21234 202537086 202537809 723 0
TFAP2C MCF7GSE21234 202555217 202555903 686 0
USF1 HepG2E 202489641 202490064 423 0
USF1 HepG2E 202522854 202523968 1114 0
USF2 HepG2E 202522854 202523474 620 0
hScc1 BcellGSE12603 202494198 202494397 199 0
hScc1 BcellGSE12603 202528196 202528416 220 0
hScc1 BcellGSE12603 202593356 202593653 297 0
p130 QuiescentGSE19898 202586599 202586810 211 0
p130 SenescentGSE19898 202586447 202587342 895 0
p130 shRbQuiescentGSE19898 202497896 202498420 524 0
p130 shRbSenescentGSE19898 202586150 202586752 602 0
p130 shRbSenescentGSE19898 202587155 202587366 211 0
p63 keratinocytesGSE17611 202536798 202537952 1154 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
2202 EST chr1 200979591 200981621 2030 mRNA PLEKHA6 chr1 200919638 201060701 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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