Annotation Detail for KLRK1

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Basic Information Top

Gene Symbol:	KLRK1 ( CD314,D12S2489E,FLJ17759,FLJ75772,KLR,NKG2-D,NKG2D )
Gene Full Name:	killer cell lectin-like receptor subfamily K, member 1
Band:	12p13.2
Quick Links	Entrez ID:22914; OMIM: 611817; Uniprot ID:NKG2D_HUMAN; ENSEMBL ID: ENSG00000213809; HGNC ID: 18788
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:3 results
Experimental PTM Sites from dbPTM:0 results
Predicted PTM Sites by profile HMM from dbPTM:0 results

Location(AA)	Modification
131	N-linked (GlcNAc...) (Potential).
163	N-linked (GlcNAc...) (Potential).
202	N-linked (GlcNAc...) (Potential).

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_007360
Location:chr12 10416219-10451631
strand:-

Upstream the gene:0 results
Downstream the gene:7 results
Inside the gene:13 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	10412360	10412693	333	3693
Oct1	Hela	GSE14283	10415565	10415597	32	639
p130	Quiescent	GSE19898	10408072	10408400	328	7984
p130	Senescent	GSE19898	10408430	10408699	269	7655
p130	shRbQuiescent	GSE19898	10408071	10408500	429	7934
p130	shRbQuiescent	GSE19898	10408817	10409309	492	7157
p130	shRbSenescent	GSE19898	10408372	10408561	189	7753

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
FOXA1	DLD1	GSE12801	10436174	10436754	580	0
FOXA1	DLD1	GSE12801	10439172	10440022	850	0
FOXA1	MCF7	GSE15244	10439097	10439912	815	0
FoxA1	MCF7	MACSdata	10439548	10439812	264	0
Oct1	H2O2-Hela	GSE14283	10419175	10419218	43	0
Oct1	H2O2-Hela	GSE14283	10427994	10428024	30	0
Oct1	Hela	GSE14283	10419175	10419209	34	0
P300	T30-glioblastoma	GSE21026	10428933	10429626	693	0
PolII	HeLa	GSE12783	10435312	10457576	22264	0
TAF	Hela	GSE8489	10431791	10433531	1740	0
TAF	Hela	GSE8489	10439063	10439449	386	0
TFAP2C	MCF7	GSE21234	10438386	10438595	209	0
TFAP2C	MCF7	GSE21234	10439367	10439991	624	0

Validated miRNA targets

miR Walk:5 results
Tarbase V5.0:0 results

Micro RNA Name	Stem Loop Name	The chromosome that miRNA located	Publication
hsa-miR-20a	hsa-mir-20a	13	20488792
hsa-miR-20a*	hsa-mir-20a	13	20488792
hsa-miR-520b	hsa-mir-520b	19	19109132
hsa-miR-93	hsa-mir-93	7	20488792
hsa-miR-93*	hsa-mir-93	7	20488792

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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