AutismKB 2.0

Annotation Detail for SHANK2


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Basic Information Top
Gene Symbol:SHANK2 ( AUTS17,CORTBP1,CTTNBP1,ProSAP1,SHANK,SPANK-3 )
Gene Full Name: SH3 and multiple ankyrin repeat domains 2
Band: 11q13.3-q13.4
Quick LinksEntrez ID:22941; OMIM: 603290; Uniprot ID:SHAN2_HUMAN; ENSEMBL ID: ENSG00000162105; HGNC ID: 14295
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
581Phosphoserine (By similarity).
726Phosphothreonine (By similarity).
899Phosphothreonine (By similarity).
954SH3-binding (Potential).
1269Phosphoserine (By similarity).
1288O-linked (GlcNAc...) (By similarity).
1330Phosphoserine (By similarity).
1334Phosphoserine (By similarity).
1336Phosphothreonine (By similarity).
Location(AA) Modifications Resource
364Phosphoserine (By similarity).Swiss-Prot 53.0
509Phosphothreonine (By similarity).Swiss-Prot 53.0
682Phosphothreonine (By similarity).Swiss-Prot 53.0
1052Phosphoserine.Swiss-Prot 53.0
1052PhosphoserinePhospho.ELM 6.0
1071O-linked (GlcNAc...) (By similarity).Swiss-Prot 53.0
1113Phosphoserine (By similarity).Swiss-Prot 53.0
1117Phosphoserine (By similarity).Swiss-Prot 53.0
1119Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
59Phosphothreonine(MAPK)HMM predict
75Phosphotyrosine(Jak)HMM predict
153Phosphothreonine(PKA)HMM predict
157Phosphothreonine(PKC)HMM predict
162Phosphoserine(IKK)HMM predict
162Phosphoserine(PKB)HMM predict
165Phosphoserine(CK2)HMM predict
235Phosphoserine(CDC2)HMM predict
245MethylarginineHMM predict
253Phosphoserine(IKK)HMM predict
283Phosphoserine(IKK)HMM predict
287Phosphothreonine(CK2)HMM predict
301O-linkedHMM predict
301Phosphoserine(CDC2)HMM predict
301Phosphoserine(ATM)HMM predict
301Phosphoserine(IKK)HMM predict
306O-linkedHMM predict
308O-linkedHMM predict
310Phosphotyrosine(INSR)HMM predict
315Phosphoserine(CDC2)HMM predict
364Phosphoserine(CK1)HMM predict
393Phosphotyrosine(SRC)HMM predict
393Phosphotyrosine(Abl)HMM predict
393Phosphotyrosine(Syk)HMM predict
394Phosphoserine(SRC)HMM predict
405Phosphotyrosine(Jak)HMM predict
421Phosphoserine(PKG)HMM predict
426Phosphoserine(CDC2)HMM predict
446Phosphoserine(CK1)HMM predict
447Phosphoserine(CDC2)HMM predict
448O-linkedHMM predict
452Phosphoserine(ATM)HMM predict
455Phosphoserine(CK2)HMM predict
477Phosphothreonine(PKC)HMM predict
480Phosphoserine(CDC2)HMM predict
541Phosphoserine(CK1)HMM predict
547O-linkedHMM predict
547Phosphoserine(CDC2)HMM predict
578N-linkedHMM predict
589O-linkedHMM predict
589Phosphoserine(ATM)HMM predict
594O-linkedHMM predict
596O-linkedHMM predict
599O-linkedHMM predict
618Phosphoserine(MAPK)HMM predict
634Phosphoserine(PKG)HMM predict
634Phosphoserine(ATM)HMM predict
652Phosphotyrosine(Jak)HMM predict
710Phosphoserine(ATM)HMM predict
750Phosphoserine(CK2)HMM predict
772O-linkedHMM predict
772O-linkedHMM predict
834Phosphoserine(PKA)HMM predict
849Phosphothreonine(CDC2)HMM predict
849Phosphothreonine(MAPK)HMM predict
849Phosphothreonine(CDK)HMM predict
852Phosphoserine(CDC2)HMM predict
854Phosphoserine(IKK)HMM predict
856N-linkedHMM predict
858Phosphoserine(ATM)HMM predict
862N-linkedHMM predict
871Phosphoserine(IKK)HMM predict
873Phosphoserine(IKK)HMM predict
893Phosphoserine(CK2)HMM predict
902Phosphoserine(CK1)HMM predict
903Phosphoserine(CK1)HMM predict
904Phosphoserine(CK1)HMM predict
904Phosphoserine(ATM)HMM predict
911O-linkedHMM predict
913O-linkedHMM predict
919O-linkedHMM predict
992O-linkedHMM predict
1006Phosphoserine(CK1)HMM predict
1033Phosphoserine(CK1)HMM predict
1071O-linkedHMM predict
1077O-linkedHMM predict
1078Phosphothreonine(PKA)HMM predict
1079O-linkedHMM predict
1081O-linkedHMM predict
1089O-linkedHMM predict
1089Phosphoserine(ATM)HMM predict
1106Phosphoserine(CK1)HMM predict
1108Phosphothreonine(PKC)HMM predict
1113O-linkedHMM predict
1113Phosphoserine(CDC2)HMM predict
1113Phosphoserine(PKB)HMM predict
1113PhosphoserineHMM predict
1117Phosphoserine(CDC2)HMM predict
1131O-linkedHMM predict
1134O-linkedHMM predict
1134O-linkedHMM predict
1134O-linkedHMM predict
1136Phosphoserine(CDC2)HMM predict
1136Phosphoserine(CDK)HMM predict
1138O-linkedHMM predict
1138Phosphoserine(IKK)HMM predict
1146Phosphoserine(CK1)HMM predict
1149Phosphoserine(ATM)HMM predict
1167O-linkedHMM predict
1167Phosphoserine(CDC2)HMM predict
1167Phosphoserine(ATM)HMM predict
1167Phosphoserine(IKK)HMM predict
1167Phosphoserine(PKB)HMM predict
1169Phosphoserine(CDC2)HMM predict
1169Phosphoserine(IKK)HMM predict
1171Phosphoserine(CK1)HMM predict
1183Phosphothreonine(PKC)HMM predict
1241MethionineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_012309
  • Location:chr11 69991609-70185519
  • strand:-
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 69991246 69991485 239 244
CTCF CD4SISSRdata 69991246 69991485 239 244
Fos K562GSE19551 69986735 69987386 651 4549
Myc K562GSE19551 69980905 69981294 389 10510
NRSF pAbJurkat 69985800 69986115 315 5652
NRSF pAbJurkat 69988868 69989587 719 2382
Oct1 HelaGSE14283 69987895 69987931 36 3697
Oct1 HelaGSE14283 69991391 69991420 29 204
RARG MCF7GSE15244 69990026 69990923 897 1135
hScc1 BcellGSE12603 69983983 69984276 293 7480
hScc1 BcellGSE12603 69991034 69991991 957 97
hScc1 CdLSGSE12603 69990966 69991871 905 191
hScc1 G2GSE9613 69990857 69992064 1207 149
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
NRSF pAbJurkat 69997277 69997783 506 0
Oct1 H2O2-HelaGSE14283 70008592 70008620 28 0
Oct1 HelaGSE14283 69994340 69994389 49 0
Oct1 HelaGSE14283 70012346 70012378 32 0
P300 T30-glioblastomaGSE21026 70005792 70006368 576 0
RARA MCF7GSE15244 69992029 69992489 460 0
RARA MCF7GSE15244 70005462 70006187 725 0
RARG MCF7GSE15244 69992224 69992629 405 0
RARG MCF7GSE15244 70005647 70006860 1213 0
TFAP2C MCF7GSE21234 70005703 70006328 625 0
hScc1 CdLSGSE12603 69994900 69995482 582 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-181b hsa-mir-181b-1 1 20868653
hsa-miR-181b hsa-mir-181b-2 9 20868653
hsa-miR-486-3p hsa-mir-486 8 20868653
hsa-miR-486-5p hsa-mir-486 8 20868653
No data
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
4837 mRNA chr11 70154846 70159243 4397 mRNA SHANK2 chr11 69991608 70185520 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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