AutismKB 2.0

Annotation Detail for TPX2


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Basic Information Top
Gene Symbol:TPX2 ( C20orf1,C20orf2,DIL-2,DIL2,FLS353,GD:C20orf1,HCA519,HCTP4,REPP86,p100 )
Gene Full Name: TPX2, microtubule-associated, homolog (Xenopus laevis)
Band: 20q11.21
Quick LinksEntrez ID:22974; OMIM: 605917; Uniprot ID:TPX2_HUMAN; ENSEMBL ID: ENSG00000088325; HGNC ID: 1249
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
20Phosphoserine.
21Phosphoserine.
28Phosphothreonine.
33Phosphoserine.
51Phosphothreonine.
59Phosphothreonine.
72Phosphothreonine.
94Phosphoserine.
113Phosphothreonine.
121Phosphoserine.
125Phosphoserine.
147Phosphothreonine.
179Phosphothreonine.
185Phosphoserine.
186Phosphoserine.
209Phosphoserine.
218Phosphoserine.
250Phosphoserine.
257Phosphoserine.
293Phosphoserine.
305N6-acetyllysine.
310Phosphoserine.
338Phosphothreonine.
359Phosphoserine.
369Phosphothreonine.
374Phosphothreonine.
486Phosphoserine.
542Phosphoserine.
634Phosphoserine.
652Phosphoserine.
654Phosphoserine.
738Phosphoserine.
Location(AA) Modifications Resource
51Phosphothreonine.Swiss-Prot 53.0
51PhosphothreoninePhospho.ELM 6.0
72PhosphothreoninePhospho.ELM 6.0
72Phosphothreonine.Swiss-Prot 53.0
121PhosphoserinePhospho.ELM 6.0
121Phosphoserine.Swiss-Prot 53.0
125PhosphoserinePhospho.ELM 6.0
125Phosphoserine.Swiss-Prot 53.0
147Phosphothreonine.Swiss-Prot 53.0
147PhosphothreoninePhospho.ELM 6.0
186PhosphoserinePhospho.ELM 6.0
186Phosphoserine.Swiss-Prot 53.0
293Phosphoserine.Swiss-Prot 53.0
293PhosphoserinePhospho.ELM 6.0
338PhosphothreoninePhospho.ELM 6.0
338Phosphothreonine.Swiss-Prot 53.0
359PhosphoserinePhospho.ELM 6.0
359Phosphoserine.Swiss-Prot 53.0
369PhosphothreoninePhospho.ELM 6.0
369Phosphothreonine.Swiss-Prot 53.0
374PhosphothreoninePhospho.ELM 6.0
374Phosphothreonine.Swiss-Prot 53.0
486Phosphoserine.Swiss-Prot 53.0
486PhosphoserinePhospho.ELM 6.0
542Phosphoserine.Swiss-Prot 53.0
542PhosphoserinePhospho.ELM 6.0
652Phosphoserine.Swiss-Prot 53.0
652PhosphoserinePhospho.ELM 6.0
654PhosphoserinePhospho.ELM 6.0
654Phosphoserine.Swiss-Prot 53.0
738Phosphoserine.Swiss-Prot 53.0
738PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
18N-linkedHMM predict
49N-linkedHMM predict
59Phosphothreonine(MAPK)HMM predict
72Phosphothreonine(CDK)HMM predict
82Phosphotyrosine(EGFR)HMM predict
82SulfotyrosineHMM predict
82Phosphotyrosine(Syk)HMM predict
94Phosphoserine(IKK)HMM predict
163Phosphoserine(PKG)HMM predict
174Phosphoserine(CK1)HMM predict
183N-linkedHMM predict
186Phosphoserine(CDK)HMM predict
186Phosphoserine(CDC2)HMM predict
250Phosphoserine(IKK)HMM predict
250Phosphoserine(PKG)HMM predict
278Phosphotyrosine(Syk)HMM predict
282N-linkedHMM predict
293Phosphoserine(CDC2)HMM predict
382Phosphothreonine(PKC)HMM predict
450Phosphothreonine(CK2)HMM predict
486Phosphoserine(CDC2)HMM predict
586N-linkedHMM predict
646Phosphoserine(PKG)HMM predict
738Phosphoserine(CDC2)HMM predict
745PhenylalanineHMM predict
747PhenylalanineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_012112
  • Location:chr20 29790564-29853263
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
H3ac HepG2E 29785321 29785696 375 5056
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Rb GrowingGSE19898 29858807 29859021 214 5651
TFAP2C MCF7GSE21234 29861731 29862088 357 8646
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
E2F4 G0GSE7516 29790332 29791302 970 0
E2F4 SGSE7516 29790181 29791302 1121 0
ETS1 JurkatGSE17954 29790109 29791453 1344 0
Fos K562GSE19551 29790158 29791190 1032 0
GABP k562GSE8489 29790181 29792549 2368 0
H3ac HepG2E 29790181 29792727 2546 0
H3ac HepG2E 29793957 29794156 199 0
LIN54 G0GSE7516 29790415 29791095 680 0
LIN54 SGSE7516 29790297 29791338 1041 0
LIN9 G0GSE7516 29790181 29792014 1833 0
LIN9 SGSE7516 29790181 29791978 1797 0
PHF8 293TGSE20725 29790262 29791338 1076 0
PHF8 HeLaGSE20725 29789962 29791315 1353 0
Rb GrowingGSE19898 29790704 29790812 108 0
TAF HelaGSE8489 29790181 29791830 1649 0
p130 QuiescentGSE19898 29790486 29791083 597 0
p130 SenescentGSE19898 29790435 29791334 899 0
p130 shRbQuiescentGSE19898 29790324 29791328 1004 0
p130 shRbSenescentGSE19898 29790462 29791300 838 0
p130 G0GSE7516 29790259 29791978 1719 0
p130 SGSE7516 29790181 29791942 1761 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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