AutismKB 2.0

Annotation Detail for SORCS3


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Basic Information Top
Gene Symbol:SORCS3 ( SORCS )
Gene Full Name: sortilin-related VPS10 domain containing receptor 3
Band: 10q25.1
Quick LinksEntrez ID:22986; OMIM: 606285; Uniprot ID:SORC3_HUMAN; ENSEMBL ID: ENSG00000156395; HGNC ID: 16699
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
207N-linked (GlcNAc...) (Potential).
456N-linked (GlcNAc...) (Potential).
789N-linked (GlcNAc...) (Potential).
800N-linked (GlcNAc...) (Potential).
840N-linked (GlcNAc...) (Potential).
932N-linked (GlcNAc...) (Potential).
953N-linked (GlcNAc...) (Potential).
1065N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
207N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
456N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
789N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
800N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
840N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
932N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
953N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1065N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
6Phosphothreonine(PKC)HMM predict
57Phosphoserine(CDK)HMM predict
57Phosphoserine(CDC2)HMM predict
60Phosphoserine(MAPK)HMM predict
60Phosphoserine(CDC2)HMM predict
60O-linkedHMM predict
97MethylarginineHMM predict
109Phosphoserine(CDC2)HMM predict
207N-linkedHMM predict
240Phosphotyrosine(INSR)HMM predict
259N-linkedHMM predict
262N-linkedHMM predict
270Phosphoserine(ATM)HMM predict
320Phosphotyrosine(INSR)HMM predict
456N-linkedHMM predict
460N-linkedHMM predict
559Phosphotyrosine(SRC)HMM predict
561Phosphoserine(CDK)HMM predict
565O-linkedHMM predict
565Phosphoserine(PKG)HMM predict
756SulfotyrosineHMM predict
776Phosphoserine(CDC2)HMM predict
776Phosphoserine(CDK)HMM predict
789N-linkedHMM predict
793Phosphotyrosine(EGFR)HMM predict
800N-linkedHMM predict
840N-linkedHMM predict
871N-linkedHMM predict
953N-linkedHMM predict
1065N-linkedHMM predict
1067Phosphothreonine(PKC)HMM predict
1123Phosphoserine(IKK)HMM predict
1172Phosphoserine(IKK)HMM predict
1172Phosphoserine(ATM)HMM predict
1174Phosphoserine(IKK)HMM predict
1212Phosphoserine(CK2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014978
  • Location:chr10 106390848-107014982
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 106372363 106372634 271 18350
CTCF CD4SISSRdata 106372363 106372634 271 18350
H3K27me3 colorectalcancer 106387392 106388232 840 3037
Oct1 H2O2-HelaGSE14283 106383785 106383812 27 7050
hScc1 BcellGSE12603 106389983 106390474 491 620
hScc1 CdLSGSE12603 106388575 106389048 473 2037
hScc1 G2GSE9613 106390055 106390474 419 584
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 106434362 106434586 224 0
CBP T30-glioblastomaGSE21026 106434394 106434888 494 0
CTCF CD4GSE12889 106517606 106517724 118 0
CTCF CD4GSE12889 106675128 106675378 250 0
CTCF CD4SISSRdata 106517606 106517724 118 0
CTCF CD4SISSRdata 106675128 106675378 250 0
ER E2-MCF7GSE14664 106675965 106676006 41 0
ER E2-MCF7GSE14664 106928358 106928394 36 0
GABP HelaGSE8489 106761311 106761598 287 0
NFkBII GM12892GSE19485 106580624 106581972 1348 0
NRSF JurkatGSE13047 106500052 106500478 426 0
NRSF JurkatGSE13047 106573778 106575951 2173 0
NRSF JurkatSISSRdata 106500051 106500390 339 0
NRSF mAbJurkat 106498631 106499846 1215 0
NRSF mAbJurkat 106501044 106501638 594 0
NRSF mAbJurkat 106569087 106573410 4323 0
NRSF mAbJurkat 106573979 106576109 2130 0
NRSF mAbJurkat 106578476 106579589 1113 0
NRSF mAbJurkat 106580892 106581102 210 0
NRSF-mono JurkatQuESTdata 106500061 106500477 416 0
NRSF-mono JurkatQuESTdata 106573852 106575167 1315 0
NRSF-poly JurkatQuESTdata 106500058 106500470 412 0
NRSF-poly JurkatQuESTdata 106573869 106575553 1684 0
NRSF-poly JurkatQuESTdata 106575623 106576170 547 0
Nanog ESGSE20650 106574191 106574549 358 0
Nanog hESGSE18292 106517111 106517354 243 0
Nanog hESGSE18292 106550450 106550684 234 0
Nanog hESGSE18292 106674182 106674689 507 0
Oct1 H2O2-HelaGSE14283 106612702 106612733 31 0
Oct1 H2O2-HelaGSE14283 106814301 106814341 40 0
Oct1 H2O2-HelaGSE14283 106843920 106843974 54 0
Oct1 H2O2-HelaGSE14283 106925360 106925396 36 0
Oct1 HelaGSE14283 106568986 106569019 33 0
Oct1 HelaGSE14283 106592479 106592506 27 0
Oct1 HelaGSE14283 106707171 106707209 38 0
Oct1 HelaGSE14283 106742950 106742985 35 0
Oct1 HelaGSE14283 106743825 106743896 71 0
Oct1 HelaGSE14283 106768042 106768075 33 0
Oct1 HelaGSE14283 106814297 106814341 44 0
Oct1 HelaGSE14283 106843922 106843974 52 0
Oct1 HelaGSE14283 106925360 106925428 68 0
Oct4 hESGSE17917 106813635 106813849 214 0
P300 T0-glioblastomaGSE21026 106433992 106434584 592 0
TAF HelaGSE8489 106650684 106650859 175 0
TAFII hESGSE17917 106813515 106813994 479 0
hScc1 BcellGSE12603 106391024 106391520 496 0
hScc1 BcellGSE12603 106392240 106392735 495 0
hScc1 BcellGSE12603 106437249 106437403 154 0
hScc1 BcellGSE12603 106675001 106675273 272 0
hScc1 BcellGSE12603 106813553 106813835 282 0
hScc1 CdLSGSE12603 106517609 106517813 204 0
hScc1 G2GSE9613 106390956 106391564 608 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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