AutismKB 2.0

Annotation Detail for TNIK


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Basic Information Top
Gene Symbol:TNIK ( - )
Gene Full Name: TRAF2 and NCK interacting kinase
Band: 3q26.2-q26.31
Quick LinksEntrez ID:23043; OMIM: 610005; Uniprot ID:TNIK_HUMAN; ENSEMBL ID: ENSG00000154310; HGNC ID: 30765
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
319Phosphothreonine.
321Phosphotyrosine.
323Phosphotyrosine.
324Phosphoserine.
326Phosphoserine.
335Phosphoserine.
560Phosphoserine.
581Phosphothreonine.
640Phosphoserine.
677Phosphothreonine.
678Phosphoserine.
680Phosphoserine.
688Phosphoserine.
707Phosphoserine.
720Phosphoserine.
726Phosphoserine.
755Phosphoserine.
764Phosphoserine.
766Phosphoserine.
769Phosphoserine.
830Phosphoserine.
831Phosphoserine.
832Phosphoserine.
833Phosphoserine.
838Phosphoserine.
839Phosphoserine.
951Phosphoserine.
982Phosphotyrosine.
987Phosphothreonine (By similarity).
1036Phosphothreonine.
Location(AA) Modifications Resource
680Phosphoserine.Swiss-Prot 53.0
764Phosphoserine.Swiss-Prot 53.0
764PhosphoserinePhospho.ELM 6.0
769Phosphoserine.Swiss-Prot 53.0
769PhosphoserinePhospho.ELM 6.0
987Phosphothreonine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
5PhosphoserineHMM predict
5Phosphoserine(IKK)HMM predict
33N-linkedHMM predict
36Phosphotyrosine(EGFR)HMM predict
36Phosphotyrosine(INSR)HMM predict
36Phosphotyrosine(SRC)HMM predict
124Phosphothreonine(PKC)HMM predict
187Phosphothreonine(PKA)HMM predict
273N-linkedHMM predict
321SulfotyrosineHMM predict
323SulfotyrosineHMM predict
324Phosphoserine(CK2)HMM predict
326PhosphoserineHMM predict
326Phosphoserine(CK2)HMM predict
333N-linkedHMM predict
335Phosphoserine(ATM)HMM predict
548Phosphoserine(CAMK2)HMM predict
570Phosphoserine(IKK)HMM predict
570Phosphoserine(PKB)HMM predict
572Phosphoserine(CK1)HMM predict
581Phosphothreonine(MAPK)HMM predict
606O-linkedHMM predict
608Phosphoserine(ATM)HMM predict
627N-linkedHMM predict
644Phosphoserine(IKK)HMM predict
660Phosphoserine(PKC)HMM predict
677Phosphothreonine(PKA)HMM predict
688Phosphoserine(PKG)HMM predict
691N-linkedHMM predict
727Phosphoserine(IKK)HMM predict
727Phosphoserine(PKB)HMM predict
727Phosphoserine(CK1)HMM predict
734O-linkedHMM predict
735O-linkedHMM predict
735Phosphothreonine(MAPK)HMM predict
735Phosphothreonine(CDK)HMM predict
735O-linkedHMM predict
738Phosphoserine(IKK)HMM predict
738Phosphoserine(ATM)HMM predict
742Phosphoserine(ATM)HMM predict
742Phosphoserine(IKK)HMM predict
746Phosphoserine(IKK)HMM predict
746Phosphoserine(ATM)HMM predict
750Phosphoserine(IKK)HMM predict
750Phosphoserine(ATM)HMM predict
754Phosphoserine(CDC2)HMM predict
764Phosphoserine(CK1)HMM predict
764Phosphoserine(PKG)HMM predict
769Phosphoserine(IKK)HMM predict
830Phosphoserine(CK2)HMM predict
831Phosphoserine(CK2)HMM predict
832Phosphoserine(CK2)HMM predict
833Phosphoserine(CK2)HMM predict
836Phosphoserine(CK2)HMM predict
838Phosphoserine(CK1)HMM predict
839Phosphoserine(CK1)HMM predict
892Phosphoserine(IKK)HMM predict
894Phosphoserine(ATM)HMM predict
894Phosphoserine(CK1)HMM predict
915Phosphoserine(CK2)HMM predict
938O-linkedHMM predict
938Phosphoserine(IKK)HMM predict
938Phosphoserine(CDC2)HMM predict
942Phosphothreonine(MAPK)HMM predict
972Phosphoserine(PKA)HMM predict
996Phosphoserine(CK2)HMM predict
996Phosphoserine(CK1)HMM predict
1021Phosphoserine(PKG)HMM predict
1026N-linkedHMM predict
1029N-linkedHMM predict
1036Phosphothreonine(CDK)HMM predict
1042Phosphotyrosine(Jak)HMM predict
1237N-linkedHMM predict
1264Phosphotyrosine(Jak)HMM predict
1264Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015028
  • Location:chr3 172264365-172660545
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 172660269 172661195 926 187
FOXA1 MCF7GSE15244 172661525 172661986 461 1210
Gata2 K562GSE18868 172671222 172671727 505 10929
H3K4me3 colorectalcancer 172661642 172662308 666 1430
KLF4 hESGSE17917 172662689 172663007 318 2303
PHF8 293TGSE20725 172660554 172661657 1103 560
Rb SenescentGSE19898 172660776 172662001 1225 843
TAF k562GSE8489 172661525 172662672 1147 1553
hScc1 CdLSGSE12603 172659420 172661923 2503 126
hScc1 G2GSE9613 172660111 172661195 1084 108
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 172250279 172250549 270 13952
CTCF CD4SISSRdata 172250279 172250549 270 13952
CTCF JurkatGSE12889 172250351 172250549 198 13916
CTCF G2GSE9613 172249782 172250560 778 14195
FOXA1 MCF7GSE15244 172245531 172246350 819 18425
FOXA1 MCF7GSE15244 172249988 172250524 536 14110
FOXA1 MCF7GSE15244 172256169 172256911 742 7826
FoxA1 MCF7MACSdata 172246053 172246192 139 18243
hScc1 CdLSGSE12603 172250137 172250560 423 14017
hScc1 G2GSE9613 172249951 172250560 609 14110
p130 SenescentGSE19898 172250389 172250579 190 13882
p130 SenescentGSE19898 172256275 172256678 403 7889
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 172331748 172332111 363 0
CBP T0-glioblastomaGSE21026 172541753 172542294 541 0
CBP T30-glioblastomaGSE21026 172484552 172485379 827 0
CTCF CD4GSE12889 172388264 172388493 229 0
CTCF CD4GSE12889 172529284 172529534 250 0
CTCF CD4SISSRdata 172388264 172388493 229 0
CTCF CD4SISSRdata 172529284 172529534 250 0
CTCF G2GSE9613 172290388 172290742 354 0
CTCF G2GSE9613 172314176 172314500 324 0
CTCF G2GSE9613 172315914 172316340 426 0
CTCF G2GSE9613 172350332 172350557 225 0
CTCF G2GSE9613 172356047 172356229 182 0
CTCF G2GSE9613 172357739 172357917 178 0
CTCF G2GSE9613 172358373 172358655 282 0
CTCF G2GSE9613 172363439 172364014 575 0
CTCF G2GSE9613 172368812 172369379 567 0
CTCF G2GSE9613 172372214 172373560 1346 0
CTCF G2GSE9613 172375717 172375846 129 0
CTCF G2GSE9613 172383150 172383591 441 0
CTCF G2GSE9613 172388058 172388606 548 0
CTCF G2GSE9613 172406138 172406301 163 0
CTCF G2GSE9613 172458221 172458431 210 0
CTCF G2GSE9613 172462237 172462567 330 0
CTCF G2GSE9613 172464220 172464386 166 0
CTCF G2GSE9613 172475409 172475711 302 0
CTCF G2GSE9613 172543801 172544017 216 0
CTCF G2GSE9613 172578436 172578678 242 0
CTCF G2GSE9613 172627055 172627203 148 0
CTCF G2GSE9613 172653663 172654207 544 0
CTCF G2GSE9613 172659216 172659609 393 0
ER MCF7GSE19013 172461993 172463079 1086 0
FOXA1 MCF7GSE15244 172336090 172336521 431 0
FOXA1 MCF7GSE15244 172457439 172458002 563 0
FOXA1 MCF7GSE15244 172461610 172463144 1534 0
FOXA1 MCF7GSE15244 172486894 172487578 684 0
FOXA1 MCF7GSE15244 172605092 172605478 386 0
FOXA1 MCF7GSE15244 172659506 172660598 1092 0
Fos K562GSE19551 172647611 172648289 678 0
FoxA1 MCF7MACSdata 172462109 172462282 173 0
H3K4me3 colorectalcancer 172658542 172660417 1875 0
Myc K562GSE19551 172383408 172383906 498 0
Myc K562GSE19551 172608288 172608515 227 0
Myc K562GSE19551 172647864 172648128 264 0
NFkBII GM12878GSE19485 172481761 172488283 6522 0
Nanog ESGSE20650 172317219 172317905 686 0
Nanog ESGSE20650 172406828 172407278 450 0
Nanog hESGSE18292 172338557 172338802 245 0
Nanog hESGSE18292 172552817 172553431 614 0
Oct4 ESGSE20650 172317291 172317667 376 0
P300 T30-glioblastomaGSE21026 172484759 172485200 441 0
P300 T30-glioblastomaGSE21026 172541956 172542145 189 0
RARA MCF7GSE15244 172355901 172358059 2158 0
RARA MCF7GSE15244 172391341 172391722 381 0
RARA MCF7GSE15244 172447291 172447940 649 0
RARA MCF7GSE15244 172456795 172458955 2160 0
RARA MCF7GSE15244 172461714 172463144 1430 0
RARA MCF7GSE15244 172486894 172487639 745 0
RARA MCF7GSE15244 172496251 172496978 727 0
RARA MCF7GSE15244 172580662 172581023 361 0
RARA MCF7GSE15244 172583790 172584246 456 0
RARA MCF7GSE15244 172647713 172647999 286 0
RARA MCF7GSE15244 172659506 172660269 763 0
RARG MCF7GSE15244 172336045 172336521 476 0
RARG MCF7GSE15244 172461754 172462670 916 0
RARG MCF7GSE15244 172487153 172487504 351 0
RARG MCF7GSE15244 172659540 172660269 729 0
Rb SenescentGSE19898 172507194 172507495 301 0
STAT1 HeLaGSE12783 172392524 172393601 1077 0
TFAP2C MCF7GSE21234 172527735 172528365 630 0
TFAP2C MCF7GSE21234 172549751 172550280 529 0
TFAP2C MCF7GSE21234 172647837 172648139 302 0
TFAP2C MCF7GSE21234 172659595 172660363 768 0
hScc1 BcellGSE12603 172366105 172366366 261 0
hScc1 BcellGSE12603 172388023 172388606 583 0
hScc1 BcellGSE12603 172658210 172658715 505 0
hScc1 BcellGSE12603 172659506 172661525 2019 0
hScc1 CdLSGSE12603 172363402 172364181 779 0
hScc1 CdLSGSE12603 172387826 172388753 927 0
hScc1 CdLSGSE12603 172484110 172485506 1396 0
hScc1 G2GSE9613 172383187 172383591 404 0
hScc1 G2GSE9613 172388058 172388648 590 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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