AutismKB 2.0

Annotation Detail for SETX


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:SETX ( ALS4,AOA2,DKFZp781B151,FLJ12840,FLJ43459,KIAA0625,SCAR1,bA479K20.2 )
Gene Full Name: senataxin
Band: 9q34.13
Quick LinksEntrez ID:23064; OMIM: 608465; Uniprot ID:SETX_HUMAN; ENSEMBL ID: ENSG00000107290; HGNC ID: 445
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
615Phosphoserine.
956Phosphoserine.
1017Phosphoserine.
1019Phosphoserine.
1330Phosphoserine.
1621Phosphoserine.
1647N6-acetyllysine.
2087Bipartite nuclear localization signal
Location(AA) Modifications Resource
1017Phosphoserine.Swiss-Prot 53.0
1019Phosphoserine.Swiss-Prot 53.0
1621Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
14Phosphothreonine(PKC)HMM predict
25Phosphothreonine(MAPK)HMM predict
32Phosphothreonine(CK2)HMM predict
88Phosphotyrosine(INSR)HMM predict
186Phosphotyrosine(INSR)HMM predict
186Phosphotyrosine(Syk)HMM predict
186SulfotyrosineHMM predict
187Phosphotyrosine(Jak)HMM predict
229Phosphotyrosine(Abl)HMM predict
345Phosphotyrosine(Syk)HMM predict
383Phosphotyrosine(SRC)HMM predict
383Phosphotyrosine(Abl)HMM predict
405N-linkedHMM predict
445N-linkedHMM predict
497O-linkedHMM predict
497O-linkedHMM predict
497Phosphothreonine(PKC)HMM predict
504Phosphoserine(CK2)HMM predict
525Phosphoserine(IKK)HMM predict
642Phosphoserine(CDC2)HMM predict
673Phosphotyrosine(EGFR)HMM predict
722O-linkedHMM predict
760Phosphothreonine(CK2)HMM predict
775Phosphothreonine(PKC)HMM predict
780Phosphothreonine(PKC)HMM predict
814N-linkedHMM predict
819N-linkedHMM predict
829Phosphothreonine(PKA)HMM predict
911Phosphoserine(CDC2)HMM predict
922Phosphoserine(CK2)HMM predict
928Phosphoserine(CK1)HMM predict
929N-linkedHMM predict
937N-linkedHMM predict
947Phosphoserine(ATM)HMM predict
954Phosphothreonine(CK2)HMM predict
980Phosphoserine(CDC2)HMM predict
983N-linkedHMM predict
1019Phosphoserine(CK2)HMM predict
1029Phosphoserine(CK1)HMM predict
1100N-linkedHMM predict
1101N-linkedHMM predict
1116N-linkedHMM predict
1119N-linkedHMM predict
1146Phosphoserine(PKG)HMM predict
1148Phosphoserine(PKG)HMM predict
1165Phosphoserine(PKG)HMM predict
1165PhosphoserineHMM predict
1178Phosphoserine(CDC2)HMM predict
1206Phosphoserine(PKG)HMM predict
1206Phosphoserine(CK1)HMM predict
1206Phosphoserine(PKB)HMM predict
1206PhosphoserineHMM predict
1207Phosphothreonine(CDK)HMM predict
1216Phosphothreonine(PKA)HMM predict
1217Phosphothreonine(PKC)HMM predict
1223O-linkedHMM predict
1241Phosphothreonine(CDC2)HMM predict
1241Phosphothreonine(MAPK)HMM predict
1241Phosphothreonine(CDK)HMM predict
1254N-linkedHMM predict
1258N-linkedHMM predict
1265O-linkedHMM predict
1300Phosphoserine(ATM)HMM predict
1366Phosphoserine(PKA)HMM predict
1366Phosphoserine(PKA)HMM predict
1366Phosphoserine(PKG)HMM predict
1366Phosphoserine(PKB)HMM predict
1391Phosphoserine(CK2)HMM predict
1397N-linkedHMM predict
1448N-linkedHMM predict
1454N-linkedHMM predict
1489Phosphoserine(CK2)HMM predict
1517Phosphotyrosine(INSR)HMM predict
1535Phosphoserine(CK1)HMM predict
1543Phosphoserine(IKK)HMM predict
1601O-linkedHMM predict
1621Phosphoserine(CDC2)HMM predict
1621Phosphoserine(MAPK)HMM predict
1621Phosphoserine(CDK)HMM predict
1665N-linkedHMM predict
1666N-linkedHMM predict
1668N-linkedHMM predict
1686Phosphoserine(CDC2)HMM predict
1686Phosphoserine(CDK)HMM predict
1694Phosphoserine(ATM)HMM predict
1696Phosphoserine(IKK)HMM predict
1728Phosphoserine(IKK)HMM predict
1766Phosphoserine(CDC2)HMM predict
1825Phosphothreonine(PKA)HMM predict
1836Phosphotyrosine(INSR)HMM predict
1847Phosphothreonine(PKA)HMM predict
1848Phosphoserine(PKA)HMM predict
1967Phosphothreonine(PKC)HMM predict
2089SulfotyrosineHMM predict
2154O-linkedHMM predict
2297Phosphotyrosine(Syk)HMM predict
2311N-linkedHMM predict
2314Phosphotyrosine(INSR)HMM predict
2316N-linkedHMM predict
2409N-linkedHMM predict
2503Phosphoserine(IKK)HMM predict
2562Phosphoserine(CDC2)HMM predict
2569O-linkedHMM predict
2572O-linkedHMM predict
2612O-linkedHMM predict
2612Phosphoserine(CDC2)HMM predict
2612Phosphoserine(MAPK)HMM predict
2620Phosphoserine(IKK)HMM predict
2639Phosphoserine(CAMK2)HMM predict
2639Phosphoserine(CK1)HMM predict
2648Phosphoserine(CK1)HMM predict
2671Phosphoserine(CK1)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015046
  • Location:chr9 134126648-134220192
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
P300 T30-glioblastomaGSE21026 134219755 134221002 1247 186
PHF8 293TGSE20725 134219728 134220721 993 32
PHF8 Hs68minusFBSGSE20725 134219559 134220912 1353 43
TFAP2C MCF7GSE21234 134220363 134220837 474 408
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 134117944 134118073 129 8640
CTCF CD4GSE12889 134124399 134124789 390 2055
CTCF CD4SISSRdata 134117944 134118073 129 8640
CTCF CD4SISSRdata 134124399 134124789 390 2055
Myc K562GSE19551 134124336 134124732 396 2115
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 134134040 134134347 307 0
CTCF CD4SISSRdata 134134040 134134347 307 0
FOXA1 MCF7GSE15244 134134857 134135719 862 0
GABP k562GSE8489 134213613 134213823 210 0
GABP k562GSE8489 134218796 134219417 621 0
H3K4me3 colorectalcancer 134217868 134219417 1549 0
H3ac HepG2E 134218283 134219417 1134 0
NRSF JurkatGSE13047 134177227 134177580 353 0
NRSF JurkatSISSRdata 134177345 134177494 149 0
NRSF mAbJurkat 134176970 134177952 982 0
NRSF-mono JurkatQuESTdata 134177309 134177579 270 0
NRSF-poly JurkatQuESTdata 134177228 134177512 284 0
PHF8 HeLaGSE20725 134219079 134220564 1485 0
PHF8 Hs68plusFBSGSE20725 134219067 134220710 1643 0
Pol2 GM12878GSE19551 134219522 134220769 1247 0
RARA MCF7GSE15244 134134422 134135791 1369 0
TAF HelaGSE8489 134218638 134219417 779 0
TAF k562GSE8489 134217868 134219417 1549 0
hScc1 BcellGSE12603 134134960 134135501 541 0
hScc1 BcellGSE12603 134219746 134220289 543 0
p63 keratinocytesGSE17611 134206483 134207321 838 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
27140 EST chr9 132168833 132169913 681 mRNA ALS4 chr9 132168836 132259926Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved