AutismKB 2.0

Annotation Detail for HECW1


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Basic Information Top
Gene Symbol:HECW1 ( KIAA0322,NEDL1 )
Gene Full Name: HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
Band: 7p14.1-p13
Quick LinksEntrez ID:23072; OMIM: 610384; Uniprot ID:HECW1_HUMAN; ENSEMBL ID: ENSG00000002746; HGNC ID: 22195
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
No data
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Location(AA) Modification Resource
24Phosphoserine(CDK)HMM predict
67O-linkedHMM predict
68Phosphoserine(CK1)HMM predict
75Phosphoserine(CK1)HMM predict
134N-linkedHMM predict
173O-linkedHMM predict
178O-linkedHMM predict
178O-linkedHMM predict
178Phosphothreonine(PKC)HMM predict
182Phosphoserine(PKG)HMM predict
228Phosphotyrosine(Jak)HMM predict
354Phosphoserine(CK1)HMM predict
387PhosphoserineHMM predict
388Phosphoserine(CK1)HMM predict
482Phosphothreonine(PKC)HMM predict
540Phosphoserine(IKK)HMM predict
555Phosphothreonine(CDC2)HMM predict
555Phosphothreonine(MAPK)HMM predict
624Phosphothreonine(MAPK)HMM predict
656Phosphoserine(IKK)HMM predict
658Phosphoserine(ATM)HMM predict
660Phosphoserine(CK1)HMM predict
661Phosphoserine(ATM)HMM predict
669Phosphoserine(IKK)HMM predict
676Phosphoserine(IKK)HMM predict
681O-linkedHMM predict
690O-linkedHMM predict
691O-linkedHMM predict
696O-linkedHMM predict
701O-linkedHMM predict
720Phosphoserine(PKA)HMM predict
721Phosphoserine(PKA)HMM predict
728Phosphoserine(PKG)HMM predict
735Phosphoserine(CK2)HMM predict
748Phosphoserine(IKK)HMM predict
752Phosphoserine(IKK)HMM predict
808Phosphoserine(ATM)HMM predict
812Phosphoserine(ATM)HMM predict
812Phosphoserine(IKK)HMM predict
824SulfotyrosineHMM predict
852N-linkedHMM predict
865Phosphothreonine(MAPK)HMM predict
872Phosphoserine(PKG)HMM predict
874Phosphoserine(CAMK2)HMM predict
874Phosphoserine(PKA)HMM predict
874Phosphoserine(IKK)HMM predict
897PhosphoserineHMM predict
897Phosphoserine(CK1)HMM predict
901Phosphoserine(IKK)HMM predict
901Phosphoserine(CK1)HMM predict
903Phosphoserine(ATM)HMM predict
921Phosphoserine(CK2)HMM predict
921Phosphoserine(IKK)HMM predict
926Phosphoserine(CK1)HMM predict
926Phosphoserine(ATM)HMM predict
926Phosphoserine(IKK)HMM predict
929Phosphoserine(PKA)HMM predict
939Phosphoserine(CDC2)HMM predict
970N-linkedHMM predict
1073Phosphoserine(PKB)HMM predict
1104Phosphoserine(ATM)HMM predict
1142N-linkedHMM predict
1144Phosphothreonine(PKC)HMM predict
1197O-linkedHMM predict
1205Phosphoserine(CDC2)HMM predict
1205Phosphoserine(CDK)HMM predict
1221Phosphoserine(CDC2)HMM predict
1292Phosphotyrosine(INSR)HMM predict
1311Phosphotyrosine(Syk)HMM predict
1320N-linkedHMM predict
1382Phosphotyrosine(Syk)HMM predict
1382Phosphotyrosine(INSR)HMM predict
1382SulfotyrosineHMM predict
1398N-linkedHMM predict
1418Phosphothreonine(PKC)HMM predict
1473Phosphoserine(CAMK2)HMM predict
1497N-linkedHMM predict
1498N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015052
  • Location:chr7 43118722-43569462
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF JurkatGSE12889 43114609 43114901 292 3968
Fos K562GSE19551 43110812 43111440 628 7597
H3K27me3 colorectalcancer 43117071 43118585 1514 895
Myc K562GSE19551 43114451 43114935 484 4030
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 43578323 43579468 1145 9433
Fos K562GSE19551 43578541 43579152 611 9384
Myc K562GSE19551 43578596 43578948 352 9310
Oct1 HelaGSE14283 43571535 43571576 41 2093
P300 T30-glioblastomaGSE21026 43578282 43579386 1104 9372
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 43227499 43227873 374 0
CTCF CD4GSE12889 43267478 43267679 201 0
CTCF CD4GSE12889 43445993 43446185 192 0
CTCF CD4SISSRdata 43267478 43267679 201 0
CTCF CD4SISSRdata 43445993 43446185 192 0
CTCF G2GSE9613 43118871 43119221 350 0
CTCF G2GSE9613 43119610 43119990 380 0
CTCF G2GSE9613 43156888 43157281 393 0
CTCF G2GSE9613 43201535 43201674 139 0
CTCF G2GSE9613 43203767 43204076 309 0
CTCF G2GSE9613 43215286 43215456 170 0
CTCF G2GSE9613 43241011 43241263 252 0
CTCF G2GSE9613 43255167 43255526 359 0
CTCF G2GSE9613 43267358 43267734 376 0
CTCF G2GSE9613 43287289 43287438 149 0
CTCF G2GSE9613 43308403 43308622 219 0
CTCF G2GSE9613 43317622 43317811 189 0
CTCF G2GSE9613 43323265 43323514 249 0
CTCF G2GSE9613 43445771 43446514 743 0
CTCF G2GSE9613 43450507 43451523 1016 0
CTCF G2GSE9613 43461117 43461549 432 0
CTCF G2GSE9613 43468349 43468522 173 0
CTCF G2GSE9613 43473354 43473539 185 0
CTCF G2GSE9613 43473948 43474579 631 0
CTCF G2GSE9613 43485570 43486001 431 0
CTCF G2GSE9613 43515732 43516066 334 0
CTCF G2GSE9613 43542521 43543106 585 0
CTCF G2GSE9613 43563354 43563749 395 0
ER Breast-CancerGSE22609 43308161 43309003 842 0
ER E2-MCF7GSE14664 43318311 43318354 43 0
ER Fulvestrant-MCF7GSE14664 43318310 43318354 44 0
ER Fulvestrant-MCF7GSE14664 43318459 43318490 31 0
H3K27me3 colorectalcancer 43119853 43122309 2456 0
NFkBII GM10847GSE19485 43170536 43171414 878 0
NFkBII GM12878GSE19485 43170387 43172300 1913 0
NFkBII GM12892GSE19485 43170537 43171854 1317 0
NRSF pAbJurkat 43338521 43338846 325 0
Nanog hESGSE18292 43204926 43205214 288 0
Nanog hESGSE18292 43297790 43298460 670 0
Nanog hESGSE18292 43402081 43403031 950 0
Oct1 H2O2-HelaGSE14283 43130403 43130430 27 0
Oct1 H2O2-HelaGSE14283 43142571 43142617 46 0
Oct1 H2O2-HelaGSE14283 43144376 43144406 30 0
Oct1 H2O2-HelaGSE14283 43178674 43178706 32 0
Oct1 H2O2-HelaGSE14283 43187961 43188013 52 0
Oct1 H2O2-HelaGSE14283 43259262 43259291 29 0
Oct1 H2O2-HelaGSE14283 43272509 43272535 26 0
Oct1 H2O2-HelaGSE14283 43277926 43277963 37 0
Oct1 H2O2-HelaGSE14283 43424432 43424466 34 0
Oct1 H2O2-HelaGSE14283 43424646 43424695 49 0
Oct1 H2O2-HelaGSE14283 43451441 43451469 28 0
Oct1 H2O2-HelaGSE14283 43490224 43490251 27 0
Oct1 HelaGSE14283 43142571 43142616 45 0
Oct1 HelaGSE14283 43144377 43144406 29 0
Oct1 HelaGSE14283 43178674 43178707 33 0
Oct1 HelaGSE14283 43187953 43188013 60 0
Oct1 HelaGSE14283 43249838 43249876 38 0
Oct1 HelaGSE14283 43272510 43272537 27 0
Oct1 HelaGSE14283 43318463 43318501 38 0
Oct1 HelaGSE14283 43338367 43338416 49 0
Oct1 HelaGSE14283 43385285 43385322 37 0
Oct1 HelaGSE14283 43424432 43424463 31 0
Oct1 HelaGSE14283 43424647 43424697 50 0
Oct1 HelaGSE14283 43436758 43436798 40 0
Oct1 HelaGSE14283 43489478 43489514 36 0
Oct1 HelaGSE14283 43490218 43490255 37 0
Oct4 hESGSE17917 43267589 43267987 398 0
P300 T0-glioblastomaGSE21026 43210064 43210832 768 0
P300 T30-glioblastomaGSE21026 43125217 43126089 872 0
P300 T30-glioblastomaGSE21026 43541705 43542617 912 0
STAT1 IFNSISSRdata 43334993 43335597 604 0
Sox2 hESGSE18292 43204991 43205216 225 0
Stat6 IL-4-hr4GSE17850 43120057 43120632 575 0
TAF HelaGSE8489 43331010 43331405 395 0
TFAP2C MCF7GSE21234 43246703 43247124 421 0
TFAP2C MCF7GSE21234 43267487 43267869 382 0
TFAP2C MCF7GSE21234 43294560 43294921 361 0
TFAP2C MCF7GSE21234 43368946 43369580 634 0
hScc1 BcellGSE12603 43267297 43267766 469 0
hScc1 BcellGSE12603 43445560 43446315 755 0
hScc1 BcellGSE12603 43451074 43451451 377 0
hScc1 BcellGSE12603 43461043 43461479 436 0
hScc1 CdLSGSE12603 43267297 43267931 634 0
hScc1 CdLSGSE12603 43445560 43446514 954 0
hScc1 CdLSGSE12603 43460933 43461801 868 0
hScc1 CdLSGSE12603 43462298 43462708 410 0
hScc1 G2GSE9613 43460897 43461479 582 0
hScc1 G2GSE9613 43485570 43485894 324 0
hScc1 G2GSE9613 43563354 43563749 395 0
p63 keratinocytesGSE17611 43154099 43154952 853 0
p63 keratinocytesGSE17611 43522584 43523717 1133 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
23919 mRNA HECW1 chr7 43124601 43376178 529 EST chr7 43255598 43257585Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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