AutismKB 2.0

Annotation Detail for FOXO1


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:FOXO1 ( FKH1,FKHR,FOXO1A )
Gene Full Name: forkhead box O1
Band: 13q14.11
Quick LinksEntrez ID:2308; OMIM: 136533; Uniprot ID:FOXO1_HUMAN; ENSEMBL ID: ENSG00000150907; HGNC ID: 3819
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
24Phosphothreonine; by PKB/AKT1.
256Phosphoserine; by PKB/AKT1.
287Phosphoserine.
319Phosphoserine; by PKB/AKT1.
322Phosphoserine; by CK1.
325Phosphoserine; by CK1.
329Phosphoserine; by DYRK1A.
467Phosphothreonine (By similarity).
468Phosphoserine (By similarity).
505Phosphoserine.
509Phosphoserine.
Location(AA) Modifications Resource
24Phosphothreonine (by PKB/AKT1).Swiss-Prot 53.0
24Phosphothreonine (PKB
256Phosphoserine (PKB
256Phosphoserine (by PKB/AKT1).Swiss-Prot 53.0
319Phosphoserine (by PKB/AKT1).Swiss-Prot 53.0
319Phosphoserine (PKB
322Phosphoserine (PKB
325Phosphoserine (PKB
329Phosphoserine (by DYRK1A).Swiss-Prot 53.0
329Phosphoserine (DYRK1A)Phospho.ELM 6.0
467Phosphothreonine (By similarity).Swiss-Prot 53.0
468Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
22Phosphoserine(IKK)HMM predict
24PhosphothreonineHMM predict
33Phosphoserine(ATM)HMM predict
33O-linkedHMM predict
37Phosphoserine(IKK)HMM predict
39O-linkedHMM predict
39O-linkedHMM predict
40O-linkedHMM predict
41Phosphoserine(ATM)HMM predict
41Phosphoserine(CDC2)HMM predict
41Phosphoserine(IKK)HMM predict
41PhosphoserineHMM predict
41Phosphoserine(CDK)HMM predict
45O-linkedHMM predict
60O-linkedHMM predict
62O-linkedHMM predict
67O-linkedHMM predict
132Phosphoserine(ATM)HMM predict
153Phosphoserine(CDC2)HMM predict
154Phosphoserine(CDC2)HMM predict
182Phosphothreonine(PKC)HMM predict
187Phosphotyrosine(SRC)HMM predict
249Phosphoserine(CDK)HMM predict
249Phosphoserine(CDC2)HMM predict
256Phosphoserine(PKB)HMM predict
256Phosphoserine(PKA)HMM predict
256Phosphoserine(CAMK2)HMM predict
259N-linkedHMM predict
260N-linkedHMM predict
290Phosphoserine(ATM)HMM predict
293O-linkedHMM predict
298Phosphoserine(CDC2)HMM predict
309N-linkedHMM predict
319Phosphoserine(PKB)HMM predict
319Phosphoserine(IKK)HMM predict
320N-linkedHMM predict
329Phosphoserine(CDK)HMM predict
366Phosphoserine(CK2)HMM predict
383Phosphoserine(MAPK)HMM predict
383Phosphoserine(CDC2)HMM predict
386O-linkedHMM predict
386Phosphoserine(IKK)HMM predict
388O-linkedHMM predict
390O-linkedHMM predict
394Phosphoserine(IKK)HMM predict
394Phosphoserine(CDC2)HMM predict
394O-linkedHMM predict
406O-linkedHMM predict
412O-linkedHMM predict
412O-linkedHMM predict
413O-linkedHMM predict
416Phosphoserine(CDC2)HMM predict
424SulfotyrosineHMM predict
432Phosphoserine(CDC2)HMM predict
432Phosphoserine(MAPK)HMM predict
445N-linkedHMM predict
447Phosphoserine(CK1)HMM predict
449Phosphotyrosine(INSR)HMM predict
509Phosphoserine(ATM)HMM predict
518N-linkedHMM predict
544O-linkedHMM predict
545O-linkedHMM predict
587Phosphotyrosine(INSR)HMM predict
638N-linkedHMM predict
655GlycineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002015
  • Location:chr13 40027818-40138733
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 40155217 40155434 217 16592
CTCF CD4SISSRdata 40155217 40155434 217 16592
CTCF JurkatGSE12889 40155223 40155388 165 16572
Fos K562GSE19551 40138614 40139112 498 130
Oct4 hESGSE21916 40152633 40153429 796 14298
STAT1 HeLaGSE12782 40153617 40155418 1801 15784
STAT1 HeLaGSE12783 40153651 40155384 1733 15784
STAT1 IFNSISSRdata 40154407 40155429 1022 16185
hScc1 BcellGSE12603 40140417 40140779 362 1865
hScc1 BcellGSE12603 40154582 40155394 812 16255
hScc1 CdLSGSE12603 40140348 40140914 566 1898
hScc1 CdLSGSE12603 40154826 40155394 568 16377
hScc1 G2GSE9613 40155046 40155394 348 16487
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 40025228 40025601 373 2404
FoxA1 MCF7MACSdata 40012633 40012824 191 15090
Nanog hESGSE18292 40012623 40013024 401 14995
RARA MCF7GSE15244 40008714 40009456 742 18734
RARG MCF7GSE15244 40008714 40009530 816 18697
TFAP2C MCF7GSE21234 40017872 40018520 648 9623
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 40035091 40035234 143 0
CTCF G2GSE9613 40038244 40038480 236 0
CTCF G2GSE9613 40050564 40050707 143 0
CTCF G2GSE9613 40087726 40088039 313 0
CTCF G2GSE9613 40107772 40108036 264 0
CTCF G2GSE9613 40136485 40138942 2457 0
GABP HelaGSE8489 40106361 40106608 247 0
H3ac HepG2E 40135804 40136088 284 0
Nanog hESGSE18292 40123898 40124473 575 0
Oct1 H2O2-HelaGSE14283 40124784 40124817 33 0
Oct1 HelaGSE14283 40034037 40034086 49 0
Oct1 HelaGSE14283 40036128 40036159 31 0
Oct1 HelaGSE14283 40122967 40122997 30 0
Oct4 hESGSE21916 40123795 40124608 813 0
Pol2 GM12878GSE19551 40138456 40138830 374 0
PolII HeLaGSE12783 40136532 40139315 2783 0
TFAP2C MCF7GSE21234 40111191 40111597 406 0
hScc1 BcellGSE12603 40044793 40045352 559 0
hScc1 BcellGSE12603 40136419 40138660 2241 0
hScc1 CdLSGSE12603 40137350 40139609 2259 0
hScc1 G2GSE9613 40136419 40139019 2600 0
p63 keratinocytesGSE17611 40061549 40062516 967 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-128 hsa-mir-128-1 2 20028871
hsa-miR-128 hsa-mir-128-2 3 20028871
hsa-miR-152 hsa-mir-152 17 20028871
hsa-miR-153 hsa-mir-153-1 2 20028871
hsa-miR-153 hsa-mir-153-2 7 20028871
hsa-miR-182 hsa-mir-182 7 20935646
hsa-miR-182 hsa-mir-182 7 20028871
hsa-miR-182 hsa-mir-182 7 19574223
hsa-miR-182* hsa-mir-182 7 20935646
hsa-miR-182* hsa-mir-182 7 20028871
hsa-miR-182* hsa-mir-182 7 19574223
hsa-miR-183 hsa-mir-183 7 20028871
hsa-miR-183* hsa-mir-183 7 20028871
hsa-miR-186 hsa-mir-186 1 20028871
hsa-miR-186* hsa-mir-186 1 20028871
hsa-miR-217 hsa-mir-217 2 19786632
hsa-miR-27a hsa-mir-27a 19 20028871
hsa-miR-27a hsa-mir-27a 19 19574223
hsa-miR-27a* hsa-mir-27a 19 20028871
hsa-miR-27a* hsa-mir-27a 19 19574223
hsa-miR-27b hsa-mir-27b 9 20028871
hsa-miR-27b* hsa-mir-27b 9 20028871
hsa-miR-29a hsa-mir-29a 7 20028871
hsa-miR-29a* hsa-mir-29a 7 20028871
hsa-miR-34a hsa-mir-34a 1 20424141
hsa-miR-34a* hsa-mir-34a 1 20424141
hsa-miR-486-3p hsa-mir-486 8 20142475
hsa-miR-486-3p hsa-mir-486 8 20028871
hsa-miR-486-5p hsa-mir-486 8 20142475
hsa-miR-486-5p hsa-mir-486 8 20028871
hsa-miR-9 hsa-mir-9-1 1 20028871
hsa-miR-9 hsa-mir-9-2 5 20028871
hsa-miR-9 hsa-mir-9-3 15 20028871
hsa-miR-96 hsa-mir-96 7 20028871
hsa-miR-96 hsa-mir-96 7 19574223
hsa-miR-96* hsa-mir-96 7 20028871
hsa-miR-96* hsa-mir-96 7 19574223
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


Copyright © 2017, Center for Bioinformatics , Peking University | All Rights Reserved