AutismKB 2.0

Annotation Detail for FOXO3


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Basic Information Top
Gene Symbol:FOXO3 ( AF6q21,DKFZp781A0677,FKHRL1,FKHRL1P2,FOXO2,FOXO3A,MGC12739,MGC31925 )
Gene Full Name: forkhead box O3
Band: 6q21
Quick LinksEntrez ID:2309; OMIM: 602681; Uniprot ID:FOXO3_HUMAN; ENSEMBL ID: ENSG00000118689; HGNC ID: 3821
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
7Phosphoserine.
12Phosphoserine.
32Phosphothreonine; by PKB/AKT1.
209Phosphoserine; by STK4.
253Phosphoserine; by PKB/AKT1.
259Nuclear localization signal.
280Phosphoserine.
284Phosphoserine.
286Phosphoserine.
315Phosphoserine; by SGK.
421Phosphoserine.
427Phosphothreonine.
Location(AA) Modifications Resource
32Phosphothreonine (by PKB/AKT1).Swiss-Prot 53.0
32Phosphothreonine (PKB
209Phosphoserine (by STK4).Swiss-Prot 53.0
253Phosphoserine (by PKB/AKT1).Swiss-Prot 53.0
253Phosphoserine (PKB
315Phosphoserine (SGK
315Phosphoserine (by SGK).Swiss-Prot 53.0
318PhosphoserinePhospho.ELM 6.0
321PhosphoserinePhospho.ELM 6.0
644Phosphoserine (IKK-beta)Phospho.ELM 6.0
Location(AA) Modification Resource
7O-linkedHMM predict
7Phosphoserine(MAPK)HMM predict
7Phosphoserine(CDC2)HMM predict
12Phosphoserine(MAPK)HMM predict
30Phosphoserine(IKK)HMM predict
32PhosphothreonineHMM predict
43Phosphoserine(CDC2)HMM predict
43Phosphoserine(CDK)HMM predict
110Phosphoserine(ATM)HMM predict
110O-linkedHMM predict
110Phosphoserine(IKK)HMM predict
173Phosphoserine(CDC2)HMM predict
179Phosphothreonine(PKC)HMM predict
184Phosphotyrosine(SRC)HMM predict
213N-linkedHMM predict
253Phosphoserine(PKA)HMM predict
253Phosphoserine(CAMK2)HMM predict
253Phosphoserine(PKG)HMM predict
253Phosphoserine(PKB)HMM predict
253Phosphoserine(IKK)HMM predict
260Phosphotyrosine(Jak)HMM predict
276Phosphothreonine(PKC)HMM predict
284Phosphoserine(IKK)HMM predict
286Phosphoserine(ATM)HMM predict
294Phosphoserine(CDC2)HMM predict
296Phosphothreonine(PKC)HMM predict
300Phosphoserine(CK2)HMM predict
315Phosphoserine(IKK)HMM predict
315Phosphoserine(PKB)HMM predict
316N-linkedHMM predict
325Phosphoserine(CDK)HMM predict
344Phosphoserine(MAPK)HMM predict
353Phosphoserine(IKK)HMM predict
353O-linkedHMM predict
355Phosphoserine(ATM)HMM predict
355Phosphoserine(CDK)HMM predict
355Phosphoserine(CDC2)HMM predict
357Phosphoserine(ATM)HMM predict
393N-linkedHMM predict
399Phosphoserine(IKK)HMM predict
399Phosphoserine(ATM)HMM predict
402Phosphoserine(CDK)HMM predict
402Phosphoserine(IKK)HMM predict
402Phosphoserine(CDC2)HMM predict
417O-linkedHMM predict
425PhosphoserineHMM predict
425Phosphoserine(IKK)HMM predict
425Phosphoserine(CDC2)HMM predict
427O-linkedHMM predict
431N-linkedHMM predict
433O-linkedHMM predict
467N-linkedHMM predict
480Phosphoserine(CK1)HMM predict
551Phosphoserine(PKG)HMM predict
553Phosphoserine(IKK)HMM predict
563Phosphoserine(CK1)HMM predict
564Phosphoserine(CK1)HMM predict
574Phosphoserine(IKK)HMM predict
586Phosphoserine(IKK)HMM predict
588Phosphoserine(CK1)HMM predict
588Phosphoserine(IKK)HMM predict
591O-linkedHMM predict
595O-linkedHMM predict
617N-linkedHMM predict
658N-linkedHMM predict
667PhosphoserineHMM predict
667Phosphoserine(CK1)HMM predict
667Phosphoserine(ATM)HMM predict
673GlycineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001455
  • Location:chr6 108988761-109108645
  • strand:+
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 109114742 109115083 341 6267
CTCF G2GSE9613 109117329 109117524 195 8781
ER MCF7GSE19013 109112660 109113397 737 4383
Fos K562GSE19551 109112557 109113246 689 4256
FoxA1 MCF7MACSdata 109112824 109112999 175 4266
NFkBII GM12878GSE19485 109112181 109113436 1255 4163
P300 T0-glioblastomaGSE21026 109117113 109117601 488 8712
P300 T30-glioblastomaGSE21026 109116804 109117847 1043 8680
RARA MCF7GSE15244 109112221 109113750 1529 4340
RARA MCF7GSE15244 109117050 109117977 927 8868
RARG MCF7GSE15244 109112404 109113750 1346 4432
TFAP2C MCF7GSE21234 109112596 109113266 670 4286
TFAP2C MCF7GSE21234 109114677 109115468 791 6427
TFAP2C MCF7GSE21234 109117001 109117652 651 8681
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 108988382 108989898 1516 0
CTCF G2GSE9613 109064578 109064797 219 0
CTCF G2GSE9613 109091424 109091789 365 0
CTCF G2GSE9613 109101108 109101252 144 0
ER MCF7GSE19013 109016946 109017619 673 0
ER MCF7GSE19013 109022387 109023001 614 0
ER MCF7GSE19013 109051793 109052374 581 0
ER MCF7GSE19013 109089297 109089975 678 0
Fos K562GSE19551 109006327 109006991 664 0
FoxA1 MCF7MACSdata 109105939 109106194 255 0
GABP k562GSE8489 109032440 109032845 405 0
Gata2 K562GSE18868 109006344 109006958 614 0
H3K4me3 colorectalcancer 108989854 108990479 625 0
H3ac HepG2E 108989854 108990516 662 0
KLF4 hESGSE17917 109066987 109067265 278 0
Nanog hESGSE18292 109094695 109095375 680 0
Oct1 H2O2-HelaGSE14283 109069554 109069586 32 0
Oct1 H2O2-HelaGSE14283 109071721 109071761 40 0
Oct1 HelaGSE14283 109069549 109069591 42 0
Oct1 HelaGSE14283 109093017 109093100 83 0
Rb GrowingGSE19898 108990424 108990622 198 0
Stat6 IL-4-hr4GSE17850 109002573 109003127 554 0
TFAP2C MCF7GSE21234 109017059 109017808 749 0
USF1 HepG2E 108989854 108991264 1410 0
hScc1 BcellGSE12603 108989250 108989679 429 0
hScc1 BcellGSE12603 109091388 109091751 363 0
p63 keratinocytesGSE17611 109017144 109017934 790 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-1 hsa-mir-1-2 18 19933931
hsa-miR-1 hsa-mir-1-1 20 19933931
hsa-miR-125b hsa-mir-125b-1 11 20306291
hsa-miR-125b-1* hsa-mir-125b-1 11 20306291
hsa-miR-143 hsa-mir-143 5 19464056
hsa-miR-143* hsa-mir-143 5 19464056
hsa-miR-155 hsa-mir-155 21 21304824
hsa-miR-155 hsa-mir-155 21 20371610
hsa-miR-155* hsa-mir-155 21 21304824
hsa-miR-155* hsa-mir-155 21 20371610
hsa-miR-17 hsa-mir-17 13 20656682
hsa-miR-17* hsa-mir-17 13 20656682
hsa-miR-182 hsa-mir-182 7 19188590
hsa-miR-182* hsa-mir-182 7 19188590
hsa-miR-206 hsa-mir-206 6 20388878
hsa-miR-21 hsa-mir-21 17 20371612
hsa-miR-21* hsa-mir-21 17 20371612
hsa-miR-221 hsa-mir-221 X 20388878
hsa-miR-221* hsa-mir-221 X 20388878
hsa-miR-222 hsa-mir-222 X 20388878
hsa-miR-222* hsa-mir-222 X 20388878
hsa-miR-451 hsa-mir-451 17 20679398
hsa-miR-646 hsa-mir-646 20 20306291
hsa-miR-96 hsa-mir-96 7 21203424
hsa-miR-96* hsa-mir-96 7 21203424
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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