AutismKB 2.0

Annotation Detail for IQSEC2


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Basic Information Top
Gene Symbol:IQSEC2 ( BRAG1,KIAA0522,MRX1 )
Gene Full Name: IQ motif and Sec7 domain 2
Band: Xp11.22
Quick LinksEntrez ID:23096; OMIM: 300522; Uniprot ID:IQEC2_HUMAN; ENSEMBL ID: ENSG00000124313; HGNC ID: 29059
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
82Phosphoserine (By similarity).
89Phosphotyrosine (By similarity).
383Phosphoserine (By similarity).
402Phosphoserine (By similarity).
611Phosphotyrosine (By similarity).
923Phosphotyrosine (By similarity).
1119Phosphotyrosine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
13O-linkedHMM predict
15Phosphoserine(CDC2)HMM predict
15Phosphoserine(CDK)HMM predict
89Phosphotyrosine(SRC)HMM predict
105Phosphoserine(ATM)HMM predict
123Phosphotyrosine(SRC)HMM predict
130Phosphotyrosine(EGFR)HMM predict
138Phosphoserine(PKA)HMM predict
138Phosphoserine(PKB)HMM predict
212O-linkedHMM predict
213Phosphoserine(CK1)HMM predict
214O-linkedHMM predict
214Phosphoserine(CDC2)HMM predict
214Phosphoserine(ATM)HMM predict
214Phosphoserine(IKK)HMM predict
214Phosphoserine(PKB)HMM predict
222O-linkedHMM predict
223O-linkedHMM predict
224O-linkedHMM predict
224O-linkedHMM predict
225O-linkedHMM predict
226O-linkedHMM predict
227O-linkedHMM predict
228O-linkedHMM predict
228Phosphoserine(CDC2)HMM predict
228Phosphoserine(IKK)HMM predict
255Phosphoserine(ATM)HMM predict
269O-linkedHMM predict
362Phosphoserine(PKB)HMM predict
387Phosphotyrosine(INSR)HMM predict
387Phosphotyrosine(Syk)HMM predict
438O-linkedHMM predict
491Phosphoserine(PKG)HMM predict
491Phosphoserine(CK1)HMM predict
491PhosphoserineHMM predict
502Phosphoserine(IKK)HMM predict
524O-linkedHMM predict
593Phosphoserine(IKK)HMM predict
597Phosphoserine(ATM)HMM predict
604Phosphoserine(CK1)HMM predict
621Phosphothreonine(PKC)HMM predict
625O-linkedHMM predict
658Phosphoserine(IKK)HMM predict
686N-linkedHMM predict
691Phosphoserine(CK1)HMM predict
692Phosphoserine(CK1)HMM predict
695Phosphoserine(CK1)HMM predict
696N-linkedHMM predict
700N-linkedHMM predict
710Phosphoserine(CK1)HMM predict
710Phosphoserine(IKK)HMM predict
731Phosphoserine(IKK)HMM predict
1063Phosphothreonine(PKA)HMM predict
1079Phosphotyrosine(Jak)HMM predict
1095N-linkedHMM predict
1097Phosphoserine(ATM)HMM predict
1105Phosphoserine(IKK)HMM predict
1107N-linkedHMM predict
1113Phosphoserine(PKG)HMM predict
1119Phosphotyrosine(Jak)HMM predict
1148Phosphoserine(PKA)HMM predict
1148Phosphoserine(PKG)HMM predict
1151Phosphoserine(PKA)HMM predict
1163O-linkedHMM predict
1163Phosphoserine(CDC2)HMM predict
1182Phosphotyrosine(Syk)HMM predict
1189Phosphoserine(IKK)HMM predict
1190N-linkedHMM predict
1193Phosphoserine(IKK)HMM predict
1219Phosphoserine(CAMK2)HMM predict
1222Phosphoserine(CK1)HMM predict
1223O-linkedHMM predict
1223O-linkedHMM predict
1224O-linkedHMM predict
1224O-linkedHMM predict
1226O-linkedHMM predict
1226Phosphoserine(CK1)HMM predict
1227Phosphoserine(CK1)HMM predict
1272Phosphotyrosine(Abl)HMM predict
1279O-linkedHMM predict
1279Phosphoserine(IKK)HMM predict
1295O-linkedHMM predict
1295Phosphoserine(IKK)HMM predict
1302O-linkedHMM predict
1335MethylarginineHMM predict
1356O-linkedHMM predict
1356Phosphoserine(CDC2)HMM predict
1356Phosphoserine(MAPK)HMM predict
1362O-linkedHMM predict
1362Phosphoserine(MAPK)HMM predict
1362Phosphoserine(CDK)HMM predict
1398O-linkedHMM predict
1406O-linkedHMM predict
1416Phosphoserine(CDC2)HMM predict
1416Phosphoserine(MAPK)HMM predict
1416Phosphoserine(CDK)HMM predict
1416Phosphoserine(ATM)HMM predict
1419O-linkedHMM predict
1419Phosphoserine(CDC2)HMM predict
1426O-linkedHMM predict
1434O-linkedHMM predict
1434Phosphoserine(CDC2)HMM predict
1437Phosphothreonine(CDC2)HMM predict
1437Phosphothreonine(CDK)HMM predict
1440O-linkedHMM predict
1440Phosphoserine(CDC2)HMM predict
1440Phosphoserine(MAPK)HMM predict
1440Phosphoserine(CDK)HMM predict
1446O-linkedHMM predict
1446Phosphoserine(CDC2)HMM predict
1446Phosphoserine(MAPK)HMM predict
1459O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015075
  • Location:chrX 53278783-53327520
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 53330654 53330934 280 3274
CTCF CD4SISSRdata 53330654 53330934 280 3274
CTCF G2GSE9613 53329657 53330891 1234 2754
CTCF G2GSE9613 53333326 53334096 770 6191
CTCF G2GSE9613 53338780 53339022 242 11381
Oct1 HelaGSE14283 53331025 53331052 27 3518
hScc1 BcellGSE12603 53330462 53330822 360 3122
hScc1 G2GSE9613 53333730 53334953 1223 6821
p130 SenescentGSE19898 53327710 53327931 221 300
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 53276616 53276836 220 2058
hScc1 G2GSE9613 53275805 53276218 413 2772
hScc1 G2GSE9613 53278630 53278910 280 14
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 53311381 53312266 885 0
CTCF HelaGSE12889 53285510 53285705 195 0
CTCF G2GSE9613 53278666 53278910 244 0
CTCF G2GSE9613 53279630 53280426 796 0
CTCF G2GSE9613 53280703 53280997 294 0
CTCF G2GSE9613 53281525 53282636 1111 0
CTCF G2GSE9613 53285217 53285839 622 0
CTCF G2GSE9613 53296114 53296947 833 0
CTCF G2GSE9613 53301975 53303503 1528 0
CTCF G2GSE9613 53305734 53306214 480 0
CTCF G2GSE9613 53308457 53308634 177 0
CTCF G2GSE9613 53313015 53313184 169 0
CTCF G2GSE9613 53313822 53314248 426 0
CTCF G2GSE9613 53315450 53315711 261 0
CTCF G2GSE9613 53325889 53326724 835 0
CTCF G2GSE9613 53327164 53327558 394 0
ER E2-MCF7GSE14664 53313361 53313400 39 0
ER E2-MCF7GSE14664 53315862 53315904 42 0
FOXA1 MCF7GSE15244 53309063 53309646 583 0
Gata2 K562GSE18868 53301429 53302281 852 0
Oct1 H2O2-HelaGSE14283 53292302 53292343 41 0
Oct1 HelaGSE14283 53292309 53292347 38 0
Oct1 HelaGSE14283 53292783 53292819 36 0
P300 T30-glioblastomaGSE21026 53311348 53312320 972 0
RNAII Tamoxifen-MCF7GSE14664 53292301 53292348 47 0
STAT1 IFNSISSRdata 53309219 53310025 806 0
TAF k562GSE8489 53298760 53299855 1095 0
TAF k562GSE8489 53300271 53301568 1297 0
TFAP2C MCF7GSE21234 53312800 53313281 481 0
hScc1 BcellGSE12603 53282001 53282597 596 0
hScc1 G2GSE9613 53279432 53279803 371 0
hScc1 G2GSE9613 53281567 53282665 1098 0
hScc1 G2GSE9613 53296147 53296759 612 0
hScc1 G2GSE9613 53302358 53303317 959 0
hScc1 G2GSE9613 53312545 53313184 639 0
hScc1 G2GSE9613 53327232 53327619 387 0
p130 shRbSenescentGSE19898 53308878 53309057 179 0
p63 keratinocytesGSE17611 53313818 53314702 884 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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