AutismKB 2.0

Annotation Detail for FLG


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Basic Information Top
Gene Symbol:FLG ( ATOD2 )
Gene Full Name: filaggrin
Band: 1q21.3
Quick LinksEntrez ID:2312; OMIM: 135940; Uniprot ID:FILA_HUMAN; ENSEMBL ID: ENSG00000143631; HGNC ID: 3748
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
695Phosphoserine (By similarity).
2514Phosphoserine.
2517Phosphothreonine.
3371Phosphoserine (By similarity).
3376Phosphoserine (By similarity).
3473Phosphoserine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
19Phosphoserine(PKC)HMM predict
127Phosphoserine(PKA)HMM predict
143Phosphoserine(CDC2)HMM predict
143Phosphoserine(IKK)HMM predict
143Phosphoserine(PKB)HMM predict
145MethylarginineHMM predict
147Phosphothreonine(PKC)HMM predict
154Phosphoserine(PKG)HMM predict
156Phosphoserine(CK1)HMM predict
167Phosphothreonine(PKC)HMM predict
186N-linkedHMM predict
190N-linkedHMM predict
215Phosphotyrosine(Abl)HMM predict
215Phosphotyrosine(SRC)HMM predict
224Phosphothreonine(PKC)HMM predict
244Phosphotyrosine(Syk)HMM predict
246Phosphothreonine(PKC)HMM predict
257Phosphotyrosine(EGFR)HMM predict
257Phosphotyrosine(Jak)HMM predict
262Phosphoserine(CK1)HMM predict
263Phosphoserine(PKC)HMM predict
272N-linkedHMM predict
278N-linkedHMM predict
289Phosphothreonine(PKC)HMM predict
295Phosphoserine(PKA)HMM predict
295Phosphoserine(PKG)HMM predict
295Phosphoserine(PKA)HMM predict
303Phosphoserine(CK1)HMM predict
310Phosphoserine(CK1)HMM predict
314Phosphoserine(CK1)HMM predict
314Phosphoserine(CK2)HMM predict
314Phosphoserine(IKK)HMM predict
314PhosphoserineHMM predict
352Phosphoserine(CK1)HMM predict
356Phosphoserine(CK1)HMM predict
364O-linkedHMM predict
379Phosphoserine(CDC2)HMM predict
391Phosphoserine(CAMK2)HMM predict
394Phosphoserine(CK1)HMM predict
400Phosphothreonine(PKA)HMM predict
406O-linkedHMM predict
418Phosphoserine(PKB)HMM predict
420Phosphoserine(ATM)HMM predict
420Phosphoserine(IKK)HMM predict
432Phosphoserine(CK1)HMM predict
436Phosphoserine(CK1)HMM predict
436Phosphoserine(IKK)HMM predict
458PhosphoserineHMM predict
507Phosphoserine(CK1)HMM predict
507PhosphoserineHMM predict
509Phosphoserine(CAMK2)HMM predict
524MethylarginineHMM predict
537N-linkedHMM predict
551Phosphoserine(CAMK2)HMM predict
571Phosphothreonine(PKC)HMM predict
592Phosphoserine(CK2)HMM predict
593Phosphoserine(ATM)HMM predict
601Phosphoserine(CK1)HMM predict
601Phosphoserine(IKK)HMM predict
619O-linkedHMM predict
622Phosphoserine(ATM)HMM predict
622Phosphoserine(IKK)HMM predict
627Phosphoserine(CK1)HMM predict
627Phosphoserine(ATM)HMM predict
634Phosphoserine(CK1)HMM predict
638Phosphoserine(IKK)HMM predict
680Phosphoserine(CK1)HMM predict
685Phosphothreonine(PKA)HMM predict
690Phosphoserine(CK2)HMM predict
719Phosphoserine(CK1)HMM predict
723Phosphoserine(CK1)HMM predict
723Phosphoserine(IKK)HMM predict
743Phosphoserine(PKB)HMM predict
745Phosphoserine(ATM)HMM predict
745Phosphoserine(IKK)HMM predict
748Phosphothreonine(CK2)HMM predict
757Phosphoserine(CK1)HMM predict
761Phosphoserine(CK1)HMM predict
761Phosphoserine(IKK)HMM predict
783Phosphoserine(CK1)HMM predict
805Phosphoserine(CK1)HMM predict
806Phosphoserine(CK1)HMM predict
834Phosphoserine(CAMK2)HMM predict
876Phosphoserine(CAMK2)HMM predict
883O-linkedHMM predict
887Phosphoserine(IKK)HMM predict
895Phosphothreonine(PKC)HMM predict
917Phosphoserine(CK2)HMM predict
926Phosphoserine(IKK)HMM predict
938Phosphothreonine(PKC)HMM predict
944O-linkedHMM predict
944Phosphoserine(IKK)HMM predict
947Phosphoserine(ATM)HMM predict
947Phosphoserine(IKK)HMM predict
952Phosphoserine(CK1)HMM predict
959Phosphoserine(CK1)HMM predict
963Phosphoserine(IKK)HMM predict
1001Phosphoserine(CK1)HMM predict
1002O-linkedHMM predict
1007Phosphothreonine(MAPK)HMM predict
1013O-linkedHMM predict
1013Phosphoserine(CK1)HMM predict
1028Phosphoserine(CDC2)HMM predict
1040Phosphoserine(CAMK2)HMM predict
1043Phosphoserine(CK1)HMM predict
1069Phosphoserine(ATM)HMM predict
1069Phosphoserine(IKK)HMM predict
1081Phosphoserine(CK1)HMM predict
1085Phosphoserine(CK1)HMM predict
1085Phosphoserine(IKK)HMM predict
1156Phosphoserine(CK1)HMM predict
1156PhosphoserineHMM predict
1158Phosphoserine(CAMK2)HMM predict
1200Phosphoserine(CAMK2)HMM predict
1220Phosphothreonine(PKC)HMM predict
1226Phosphoserine(IKK)HMM predict
1250Phosphoserine(CK1)HMM predict
1250Phosphoserine(IKK)HMM predict
1258Phosphoserine(CK1)HMM predict
1262Phosphothreonine(PKC)HMM predict
1271Phosphoserine(ATM)HMM predict
1271Phosphoserine(IKK)HMM predict
1276Phosphoserine(CK1)HMM predict
1280Phosphoserine(PKA)HMM predict
1280Phosphoserine(CK1)HMM predict
1280Phosphoserine(CK2)HMM predict
1287Phosphoserine(CK1)HMM predict
1287Phosphoserine(CK2)HMM predict
1325Phosphoserine(CK1)HMM predict
1329Phosphoserine(CK1)HMM predict
1334Phosphothreonine(CDK)HMM predict
1336Phosphoserine(CK1)HMM predict
1337Phosphoserine(CK1)HMM predict
1352Phosphoserine(CDC2)HMM predict
1364Phosphoserine(CAMK2)HMM predict
1367Phosphoserine(CK1)HMM predict
1371Phosphoserine(CK1)HMM predict
1391Phosphoserine(PKB)HMM predict
1393Phosphoserine(ATM)HMM predict
1393Phosphoserine(IKK)HMM predict
1405Phosphoserine(CK1)HMM predict
1409Phosphoserine(IKK)HMM predict
1431Phosphoserine(IKK)HMM predict
1451Phosphoserine(CK1)HMM predict
1453Phosphoserine(CK1)HMM predict
1475N-linkedHMM predict
1480Phosphoserine(CK1)HMM predict
1480Phosphoserine(IKK)HMM predict
1480PhosphoserineHMM predict
1482Phosphoserine(CAMK2)HMM predict
1497MethylarginineHMM predict
1500MethylarginineHMM predict
1503Phosphoserine(CAMK2)HMM predict
1523Phosphothreonine(CDC2)HMM predict
1523Phosphothreonine(CDK)HMM predict
1531O-linkedHMM predict
1535PhosphoserineHMM predict
1544Phosphothreonine(PKC)HMM predict
1574Phosphoserine(CK1)HMM predict
1574Phosphoserine(IKK)HMM predict
1584Phosphoserine(CK1)HMM predict
1586Phosphothreonine(PKC)HMM predict
1592O-linkedHMM predict
1592Phosphoserine(IKK)HMM predict
1595Phosphoserine(ATM)HMM predict
1600Phosphoserine(CK1)HMM predict
1607Phosphoserine(CK1)HMM predict
1611Phosphoserine(CK1)HMM predict
1611Phosphoserine(CK2)HMM predict
1649Phosphoserine(CK1)HMM predict
1653Phosphoserine(CK1)HMM predict
1661Phosphoserine(CK1)HMM predict
1669Phosphoserine(CK1)HMM predict
1669Phosphoserine(ATM)HMM predict
1676Phosphoserine(CDC2)HMM predict
1688Phosphoserine(CAMK2)HMM predict
1691Phosphoserine(CK1)HMM predict
1695Phosphoserine(IKK)HMM predict
1704Phosphoserine(IKK)HMM predict
1712MethylarginineHMM predict
1717Phosphoserine(ATM)HMM predict
1717Phosphoserine(IKK)HMM predict
1729Phosphoserine(CK1)HMM predict
1733Phosphoserine(IKK)HMM predict
1789MethylarginineHMM predict
1792Phosphoserine(PKG)HMM predict
1804Phosphoserine(CK1)HMM predict
1804PhosphoserineHMM predict
1806Phosphoserine(CAMK2)HMM predict
1821MethylarginineHMM predict
1835Phosphoserine(CK1)HMM predict
1836Phosphoserine(ATM)HMM predict
1839Phosphoserine(ATM)HMM predict
1848Phosphoserine(CK1)HMM predict
1855O-linkedHMM predict
1859Phosphoserine(IKK)HMM predict
1868Phosphothreonine(PKC)HMM predict
1898Phosphoserine(CK1)HMM predict
1898Phosphoserine(IKK)HMM predict
1916O-linkedHMM predict
1919Phosphoserine(ATM)HMM predict
1919Phosphoserine(IKK)HMM predict
1924Phosphoserine(CK1)HMM predict
1924Phosphoserine(ATM)HMM predict
1931Phosphoserine(CK1)HMM predict
1935Phosphoserine(IKK)HMM predict
1973Phosphoserine(CK1)HMM predict
1977Phosphoserine(CK1)HMM predict
1982Phosphothreonine(PKA)HMM predict
1985Phosphoserine(CK1)HMM predict
2016Phosphoserine(CK1)HMM predict
2020Phosphoserine(CK1)HMM predict
2042Phosphoserine(ATM)HMM predict
2054Phosphoserine(CK1)HMM predict
2058Phosphoserine(CK1)HMM predict
2058Phosphoserine(IKK)HMM predict
2080Phosphoserine(IKK)HMM predict
2102Phosphoserine(CK1)HMM predict
2129Phosphoserine(CK1)HMM predict
2129PhosphoserineHMM predict
2131Phosphoserine(CAMK2)HMM predict
2146MethylarginineHMM predict
2173Phosphoserine(CAMK2)HMM predict
2180O-linkedHMM predict
2184Phosphoserine(IKK)HMM predict
2190Phosphoserine(PKG)HMM predict
2193Phosphothreonine(PKC)HMM predict
2194Phosphotyrosine(Syk)HMM predict
2194Phosphotyrosine(INSR)HMM predict
2223Phosphoserine(CK1)HMM predict
2223Phosphoserine(IKK)HMM predict
2235Phosphothreonine(PKC)HMM predict
2241O-linkedHMM predict
2241PhosphoserineHMM predict
2242Phosphoserine(IKK)HMM predict
2244Phosphoserine(ATM)HMM predict
2244Phosphoserine(IKK)HMM predict
2249Phosphoserine(CK1)HMM predict
2256Phosphoserine(CK1)HMM predict
2260Phosphoserine(CK1)HMM predict
2260Phosphoserine(CK2)HMM predict
2260Phosphoserine(IKK)HMM predict
2262Phosphoserine(PKC)HMM predict
2298Phosphoserine(CK1)HMM predict
2302Phosphoserine(CK1)HMM predict
2310Phosphoserine(CK1)HMM predict
2340Phosphoserine(CK1)HMM predict
2344Phosphoserine(CK1)HMM predict
2364Phosphoserine(PKB)HMM predict
2366Phosphoserine(ATM)HMM predict
2366Phosphoserine(IKK)HMM predict
2378Phosphoserine(CK1)HMM predict
2382Phosphoserine(IKK)HMM predict
2404PhosphoserineHMM predict
2453Phosphoserine(CK1)HMM predict
2453PhosphoserineHMM predict
2455Phosphoserine(CK1)HMM predict
2478Phosphotyrosine(EGFR)HMM predict
2497Phosphoserine(CAMK2)HMM predict
2543Phosphoserine(CK1)HMM predict
2547Phosphoserine(IKK)HMM predict
2547PhosphoserineHMM predict
2568Phosphoserine(ATM)HMM predict
2573Phosphoserine(CK1)HMM predict
2573Phosphoserine(ATM)HMM predict
2580Phosphoserine(CK1)HMM predict
2584Phosphoserine(IKK)HMM predict
2622Phosphoserine(CK1)HMM predict
2626Phosphoserine(CK1)HMM predict
2631Phosphothreonine(PKA)HMM predict
2634O-linkedHMM predict
2664Phosphoserine(CK1)HMM predict
2668Phosphoserine(CK1)HMM predict
2690Phosphoserine(ATM)HMM predict
2702Phosphoserine(CK1)HMM predict
2706Phosphoserine(IKK)HMM predict
2750Phosphoserine(CK1)HMM predict
2751Phosphoserine(CK1)HMM predict
2762MethylarginineHMM predict
2777Phosphoserine(CK1)HMM predict
2777Phosphoserine(IKK)HMM predict
2777PhosphoserineHMM predict
2779Phosphoserine(CAMK2)HMM predict
2794MethylarginineHMM predict
2805Phosphoserine(CK1)HMM predict
2808Phosphoserine(CK1)HMM predict
2809Phosphoserine(ATM)HMM predict
2812Phosphoserine(ATM)HMM predict
2821Phosphoserine(CAMK2)HMM predict
2828O-linkedHMM predict
2832Phosphoserine(IKK)HMM predict
2840Phosphothreonine(PKC)HMM predict
2884Phosphoserine(PKA)HMM predict
2889Phosphoserine(IKK)HMM predict
2892Phosphoserine(ATM)HMM predict
2892Phosphoserine(IKK)HMM predict
2897Phosphoserine(CK1)HMM predict
2904Phosphoserine(CK1)HMM predict
2908Phosphoserine(IKK)HMM predict
2946Phosphoserine(CK1)HMM predict
2950Phosphoserine(CK1)HMM predict
2955Phosphothreonine(PKA)HMM predict
2958O-linkedHMM predict
2988Phosphoserine(CK1)HMM predict
2992Phosphoserine(CK1)HMM predict
3014Phosphoserine(ATM)HMM predict
3026Phosphoserine(CK1)HMM predict
3030Phosphoserine(IKK)HMM predict
3074Phosphoserine(CK1)HMM predict
3075Phosphoserine(CK1)HMM predict
3086MethylarginineHMM predict
3101Phosphoserine(PKA)HMM predict
3101Phosphoserine(CK1)HMM predict
3118MethylarginineHMM predict
3129Phosphoserine(CK1)HMM predict
3132Phosphoserine(CK1)HMM predict
3133Phosphoserine(ATM)HMM predict
3136Phosphoserine(ATM)HMM predict
3145Phosphoserine(CAMK2)HMM predict
3152O-linkedHMM predict
3156Phosphoserine(IKK)HMM predict
3164Phosphothreonine(PKC)HMM predict
3178Phosphoserine(CK1)HMM predict
3208Phosphoserine(PKA)HMM predict
3213Phosphoserine(IKK)HMM predict
3216Phosphoserine(ATM)HMM predict
3216Phosphoserine(IKK)HMM predict
3221Phosphoserine(CK1)HMM predict
3228Phosphoserine(CK1)HMM predict
3232Phosphoserine(IKK)HMM predict
3282Phosphoserine(CK1)HMM predict
3297Phosphoserine(CDC2)HMM predict
3309Phosphoserine(CAMK2)HMM predict
3312Phosphoserine(CK1)HMM predict
3338Phosphoserine(ATM)HMM predict
3338Phosphoserine(IKK)HMM predict
3350Phosphoserine(CK1)HMM predict
3354Phosphoserine(CK1)HMM predict
3354Phosphoserine(IKK)HMM predict
3425Phosphoserine(CK1)HMM predict
3425PhosphoserineHMM predict
3427Phosphoserine(CAMK2)HMM predict
3469Phosphoserine(CAMK2)HMM predict
3476O-linkedHMM predict
3480Phosphoserine(IKK)HMM predict
3519Phosphoserine(CAMK2)HMM predict
3519Phosphoserine(CK1)HMM predict
3519Phosphoserine(IKK)HMM predict
3519PhosphoserineHMM predict
3537O-linkedHMM predict
3540Phosphoserine(ATM)HMM predict
3540Phosphoserine(IKK)HMM predict
3545Phosphoserine(CK1)HMM predict
3545Phosphoserine(ATM)HMM predict
3552Phosphoserine(CK1)HMM predict
3556Phosphoserine(IKK)HMM predict
3594Phosphoserine(CK1)HMM predict
3598Phosphoserine(CK1)HMM predict
3606Phosphoserine(CK1)HMM predict
3636Phosphoserine(CK1)HMM predict
3640Phosphoserine(CK1)HMM predict
3660Phosphoserine(PKB)HMM predict
3662Phosphoserine(ATM)HMM predict
3662Phosphoserine(IKK)HMM predict
3674Phosphoserine(CK1)HMM predict
3678Phosphoserine(IKK)HMM predict
3700PhosphoserineHMM predict
3734MethylarginineHMM predict
3749Phosphoserine(CK1)HMM predict
3749PhosphoserineHMM predict
3751Phosphoserine(CAMK2)HMM predict
3766MethylarginineHMM predict
3769MethylarginineHMM predict
3772Phosphoserine(CAMK2)HMM predict
3793Phosphoserine(CAMK2)HMM predict
3843Phosphoserine(CAMK2)HMM predict
3843Phosphoserine(CK1)HMM predict
3843Phosphoserine(IKK)HMM predict
3843PhosphoserineHMM predict
3856Phosphoserine(PKA)HMM predict
3861Phosphoserine(IKK)HMM predict
3864Phosphoserine(ATM)HMM predict
3864Phosphoserine(IKK)HMM predict
3872Phosphotyrosine(Syk)HMM predict
3872SulfotyrosineHMM predict
3880Phosphoserine(CK1)HMM predict
3880Phosphoserine(CK2)HMM predict
3905O-linkedHMM predict
3909Phosphothreonine(PKA)HMM predict
3916O-linkedHMM predict
3920O-linkedHMM predict
3935Phosphoserine(ATM)HMM predict
3949Phosphoserine(CDC2)HMM predict
3954Phosphoserine(CK1)HMM predict
3967O-linkedHMM predict
3984SulfotyrosineHMM predict
3986SulfotyrosineHMM predict
3994Phosphoserine(ATM)HMM predict
4052Phosphoserine(ATM)HMM predict
4057TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002016
  • Location:chr1 150541274-150564302
  • strand:-
No data
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 150551026 150551302 276 0
Oct1 H2O2-HelaGSE14283 150555671 150555703 32 0
Oct1 HelaGSE14283 150555671 150555703 32 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
1582 mRNA LOC339400 chr1 149099007 149151124 704 mRNA FLG chr1 149087723 149110752Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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