AutismKB 2.0

Annotation Detail for PLXND1


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Basic Information Top
Gene Symbol:PLXND1 ( KIAA0620,MGC75353,PLEXD1 )
Gene Full Name: plexin D1
Band: 3q22.1
Quick LinksEntrez ID:23129; OMIM: 604282; Uniprot ID:PLXD1_HUMAN; ENSEMBL ID: ENSG00000004399; HGNC ID: 9107
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
86N-linked (GlcNAc...) (Potential).
155N-linked (GlcNAc...) (Potential).
188N-linked (GlcNAc...) (Potential).
224N-linked (GlcNAc...) (Potential).
481N-linked (GlcNAc...) (Potential).
500N-linked (GlcNAc...).
583N-linked (GlcNAc...) (Potential).
696N-linked (GlcNAc...) (Potential).
736N-linked (GlcNAc...) (Potential).
802N-linked (GlcNAc...) (Potential).
965N-linked (GlcNAc...) (Potential).
1017N-linked (GlcNAc...) (Potential).
1060N-linked (GlcNAc...) (Potential).
1099N-linked (GlcNAc...) (Potential).
1118N-linked (GlcNAc...) (Potential).
1132N-linked (GlcNAc...) (Potential).
1237N-linked (GlcNAc...) (Potential).
1257N-linked (GlcNAc...) (Potential).
Location(AA) Modifications Resource
86N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
155N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
188N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
224N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
481N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
500N-linked (GlcNAc...).Swiss-Prot 53.0
583N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
696N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
736N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
802N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
965N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1017N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1060N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1099N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1118N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1132N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1237N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1257N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
Location(AA) Modification Resource
19O-linkedHMM predict
19Phosphoserine(MAPK)HMM predict
25Phosphothreonine(CDC2)HMM predict
25Phosphothreonine(MAPK)HMM predict
55Phosphoserine(CDK)HMM predict
55Phosphoserine(IKK)HMM predict
55Phosphoserine(PKB)HMM predict
55Phosphoserine(CDC2)HMM predict
57Phosphothreonine(MAPK)HMM predict
121Phosphothreonine(PKA)HMM predict
188N-linkedHMM predict
224N-linkedHMM predict
226Phosphoserine(CK1)HMM predict
226Phosphoserine(PKB)HMM predict
258N-linkedHMM predict
260Phosphoserine(CK2)HMM predict
263N-linkedHMM predict
287O-linkedHMM predict
287Phosphoserine(ATM)HMM predict
298Phosphotyrosine(Jak)HMM predict
481N-linkedHMM predict
583N-linkedHMM predict
696N-linkedHMM predict
700Phosphotyrosine(EGFR)HMM predict
715O-linkedHMM predict
732Phosphoserine(IKK)HMM predict
736N-linkedHMM predict
745N-linkedHMM predict
755Phosphothreonine(CDK)HMM predict
758Phosphoserine(CDC2)HMM predict
758Phosphoserine(MAPK)HMM predict
802N-linkedHMM predict
815Phosphothreonine(PKC)HMM predict
838Phosphoserine(CDC2)HMM predict
857Phosphoserine(ATM)HMM predict
921Phosphoserine(PKA)HMM predict
941Phosphotyrosine(Jak)HMM predict
1017N-linkedHMM predict
1060N-linkedHMM predict
1075Phosphoserine(CDC2)HMM predict
1079Phosphoserine(CDK)HMM predict
1079Phosphoserine(CDC2)HMM predict
1118N-linkedHMM predict
1132N-linkedHMM predict
1146Phosphotyrosine(Abl)HMM predict
1213Phosphotyrosine(Jak)HMM predict
1257N-linkedHMM predict
1343Phosphoserine(ATM)HMM predict
1365Phosphoserine(CK1)HMM predict
1371Phosphotyrosine(INSR)HMM predict
1384Phosphoserine(ATM)HMM predict
1488Phosphoserine(PKB)HMM predict
1488Phosphoserine(PKG)HMM predict
1559N-linkedHMM predict
1638Phosphothreonine(PKC)HMM predict
1754PhosphoserineHMM predict
1754Phosphoserine(PKB)HMM predict
1817Phosphoserine(CDC2)HMM predict
1846Phosphothreonine(MAPK)HMM predict
1895N-linkedHMM predict
1914MethionineHMM predict
1919Phosphotyrosine(INSR)HMM predict
1919Phosphotyrosine(EGFR)HMM predict
1919Phosphotyrosine(Syk)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015103
  • Location:chr3 130756707-130808350
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 130809752 130810837 1085 1944
CTCF G2GSE9613 130811699 130811903 204 3451
CTCF G2GSE9613 130813827 130814312 485 5719
CTCF G2GSE9613 130816616 130816913 297 8414
CTCF G2GSE9613 130817294 130817670 376 9132
CTCF G2GSE9613 130820465 130821585 1120 12675
CTCF G2GSE9613 130822414 130823235 821 14474
CTCF G2GSE9613 130824486 130825532 1046 16659
CTCF G2GSE9613 130826369 130827202 833 18435
H3ac HepG2E 130819186 130820538 1352 11512
TFAP2C MCF7GSE21234 130823806 130824489 683 15797
TFAP2C MCF7GSE21234 130827396 130829189 1793 19942
USF1 HepG2E 130815822 130818273 2451 8697
USF2 HepG2E 130816146 130816879 733 8162
hScc1 BcellGSE12603 130825321 130825532 211 17076
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP JurkatGSE17954 130794864 130796381 1517 0
CTCF G2GSE9613 130758364 130758636 272 0
CTCF G2GSE9613 130760356 130760726 370 0
CTCF G2GSE9613 130761253 130761494 241 0
CTCF G2GSE9613 130762560 130763441 881 0
CTCF G2GSE9613 130765599 130765750 151 0
CTCF G2GSE9613 130766480 130767516 1036 0
CTCF G2GSE9613 130768512 130769355 843 0
CTCF G2GSE9613 130772693 130773562 869 0
CTCF G2GSE9613 130774851 130775330 479 0
CTCF G2GSE9613 130777033 130778898 1865 0
CTCF G2GSE9613 130779443 130780113 670 0
CTCF G2GSE9613 130780797 130781680 883 0
CTCF G2GSE9613 130782376 130782805 429 0
CTCF G2GSE9613 130783917 130784567 650 0
CTCF G2GSE9613 130785015 130785241 226 0
CTCF G2GSE9613 130786741 130786925 184 0
CTCF G2GSE9613 130787397 130787791 394 0
CTCF G2GSE9613 130790906 130791575 669 0
CTCF G2GSE9613 130793539 130793872 333 0
CTCF G2GSE9613 130794445 130795037 592 0
CTCF G2GSE9613 130796870 130797132 262 0
CTCF G2GSE9613 130797707 130798094 387 0
CTCF G2GSE9613 130802991 130803504 513 0
CTCF G2GSE9613 130804546 130808007 3461 0
FOXA1 MCF7GSE15244 130778072 130778788 716 0
FOXA1 MCF7GSE15244 130795000 130795723 723 0
FOXA1 MCF7GSE15244 130805087 130805473 386 0
FoxA1 MCF7MACSdata 130778318 130778535 217 0
H3ac HepG2E 130797132 130797399 267 0
H3ac HepG2E 130797707 130798094 387 0
Oct1 H2O2-HelaGSE14283 130802604 130802631 27 0
Oct1 H2O2-HelaGSE14283 130806226 130806264 38 0
Oct1 HelaGSE14283 130802601 130802631 30 0
Oct1 HelaGSE14283 130806226 130806264 38 0
RARG MCF7GSE15244 130778399 130778579 180 0
Rb SenescentGSE19898 130762855 130763046 191 0
Rb SenescentGSE19898 130807315 130807596 281 0
TFAP2C MCF7GSE21234 130766192 130767135 943 0
TFAP2C MCF7GSE21234 130797964 130798875 911 0
TFAP2C MCF7GSE21234 130804382 130805462 1080 0
TFAP2C MCF7GSE21234 130805911 130806806 895 0
hScc1 BcellGSE12603 130758329 130758636 307 0
hScc1 BcellGSE12603 130766051 130767546 1495 0
hScc1 BcellGSE12603 130777720 130777995 275 0
hScc1 BcellGSE12603 130778544 130779054 510 0
hScc1 BcellGSE12603 130786811 130787757 946 0
hScc1 BcellGSE12603 130794286 130794840 554 0
hScc1 BcellGSE12603 130799354 130800161 807 0
hScc1 G2GSE9613 130804546 130805545 999 0
p130 SenescentGSE19898 130761329 130761599 270 0
p130 SenescentGSE19898 130762848 130763131 283 0
p130 shRbQuiescentGSE19898 130798546 130799822 1276 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
983 Unknown pSILAC miR-155 PLXND1 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000004399 n_a n_a n_a "lymphoblast, lymphocyte, leukocyte, macrophage" "benign tumour, malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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