AutismKB 2.0

Annotation Detail for PHF8


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Basic Information Top
Gene Symbol:PHF8 ( DKFZp686E0868,JHDM1F,KIAA1111,MRXSSD,ZNF422 )
Gene Full Name: PHD finger protein 8
Band: Xp11.22
Quick LinksEntrez ID:23133; OMIM: 300560; Uniprot ID:PHF8_HUMAN; ENSEMBL ID: ENSG00000172943; HGNC ID: 20672
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
69Phosphoserine; by CDK1.
120Phosphoserine; by CDK1.
651Phosphoserine (By similarity).
705Phosphothreonine.
706Phosphothreonine.
722Phosphoserine.
804Phosphoserine.
854Phosphoserine.
857Phosphoserine.
880Phosphoserine.
Location(AA) Modifications Resource
120Phosphoserine.Swiss-Prot 53.0
120PhosphoserinePhospho.ELM 6.0
857Phosphoserine.Swiss-Prot 53.0
857PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
104Phosphoserine(CK1)HMM predict
104Phosphoserine(PKA)HMM predict
104Phosphoserine(PKG)HMM predict
104Phosphoserine(PKC)HMM predict
120Phosphoserine(CDC2)HMM predict
158Phosphoserine(ATM)HMM predict
175Phosphoserine(CDC2)HMM predict
179Phosphothreonine(PKC)HMM predict
232Phosphoserine(CK1)HMM predict
250Phosphoserine(PKA)HMM predict
311N-linkedHMM predict
319Phosphoserine(IKK)HMM predict
320Phosphoserine(CDK)HMM predict
510O-linkedHMM predict
512Phosphoserine(CAMK2)HMM predict
524N-linkedHMM predict
538MethyllysineHMM predict
539MethyllysineHMM predict
543MethyllysineHMM predict
580N-linkedHMM predict
587N-linkedHMM predict
593Phosphoserine(IKK)HMM predict
611N-linkedHMM predict
626Phosphothreonine(PKA)HMM predict
704SulfotyrosineHMM predict
720N-linkedHMM predict
751PhosphoserineHMM predict
751Phosphoserine(MAPK)HMM predict
751O-linkedHMM predict
751Phosphoserine(IKK)HMM predict
770O-linkedHMM predict
771O-linkedHMM predict
772Phosphoserine(CK1)HMM predict
773Phosphoserine(CDC2)HMM predict
773Phosphoserine(ATM)HMM predict
773Phosphoserine(IKK)HMM predict
777Phosphoserine(CK1)HMM predict
791Phosphoserine(CK1)HMM predict
791O-linkedHMM predict
791Phosphoserine(CK2)HMM predict
796Phosphoserine(IKK)HMM predict
800O-linkedHMM predict
804Phosphoserine(IKK)HMM predict
804Phosphoserine(CDC2)HMM predict
804Phosphoserine(CDK)HMM predict
807O-linkedHMM predict
810Phosphothreonine(MAPK)HMM predict
810Phosphothreonine(CDC2)HMM predict
810Phosphothreonine(CDK)HMM predict
826PhosphoserineHMM predict
834Phosphoserine(CK1)HMM predict
834Phosphoserine(CK2)HMM predict
850Phosphotyrosine(INSR)HMM predict
852Phosphotyrosine(EGFR)HMM predict
852SulfotyrosineHMM predict
857Phosphoserine(CK2)HMM predict
874Phosphoserine(PKA)HMM predict
886Phosphothreonine(PKA)HMM predict
886Phosphothreonine(CDK)HMM predict
900Phosphothreonine(PKA)HMM predict
904Phosphoserine(PKG)HMM predict
929Phosphotyrosine(Jak)HMM predict
950Phosphoserine(CK1)HMM predict
950O-linkedHMM predict
957Phosphothreonine(PKC)HMM predict
957O-linkedHMM predict
957O-linkedHMM predict
961Phosphothreonine(MAPK)HMM predict
961O-linkedHMM predict
966O-linkedHMM predict
968O-linkedHMM predict
969Phosphoserine(CDC2)HMM predict
969O-linkedHMM predict
969Phosphoserine(CDK)HMM predict
990Phosphotyrosine(Syk)HMM predict
1003N-linkedHMM predict
1021Phosphoserine(CK1)HMM predict
1021Phosphoserine(PKC)HMM predict
1021Phosphoserine(PKA)HMM predict
1021Phosphoserine(PKB)HMM predict
1021Phosphoserine(PKG)HMM predict
1049IsoleucineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015107
  • Location:chrX 53979838-54087035
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 54086770 54087573 803 136
ETS1 JurkatGSE17954 54087038 54088378 1340 673
Myc hESGSE17917 54087041 54087420 379 195
Nanog hESGSE18292 54091838 54092132 294 4950
P300 T0-glioblastomaGSE21026 54087367 54088256 889 776
P300 T30-glioblastomaGSE21026 54087014 54088132 1118 538
PHF8 HeLaGSE20725 54086754 54088359 1605 521
PHF8 Hs68minusFBSGSE20725 54086666 54088043 1377 319
PHF8 Hs68plusFBSGSE20725 54086765 54088525 1760 610
RARA MCF7GSE15244 54087573 54089075 1502 1289
RARG MCF7GSE15244 54087691 54089075 1384 1348
Sox2 hESGSE18292 54091706 54092211 505 4923
TFAP2C MCF7GSE21234 54087648 54088687 1039 1132
VDR GM10855-stimGSE22484 54086875 54088911 2036 858
VDR GM10861-stimGSE22484 54087066 54088823 1757 909
hScc1 CdLSGSE12603 54086854 54087345 491 64
hScc1 G2GSE9613 54087573 54088151 578 827
p130 shRbQuiescentGSE19898 54087492 54088128 636 775
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
STAT1 HeLaGSE12782 53973258 53974648 1390 5886
STAT1 HeLaGSE12783 53973397 53974574 1177 5853
STAT1 IFNSISSRdata 53973554 53974281 727 5921
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 54068487 54068776 289 0
CTCF G2GSE9613 54085574 54086256 682 0
FOXA1 MCF7GSE15244 54073359 54073797 438 0
H3K4me3 colorectalcancer 54086328 54087101 773 0
H3ac HepG2E 54086256 54087101 845 0
Oct1 HelaGSE14283 54061024 54061095 71 0
Oct1 HelaGSE14283 54063039 54063070 31 0
Oct1 HelaGSE14283 54071670 54071703 33 0
RNAII Tamoxifen-MCF7GSE14664 53986321 53986409 88 0
TAF HelaGSE8489 54086564 54086920 356 0
TAF k562GSE8489 54086282 54087060 778 0
TFAP2C MCF7GSE21234 54072649 54073135 486 0
USF1 HepG2E 53998575 53999045 470 0
hScc1 BcellGSE12603 54071710 54071921 211 0
hScc1 BcellGSE12603 54085795 54086282 487 0
hScc1 BcellGSE12603 54086564 54087345 781 0
hScc1 CdLSGSE12603 54085830 54086503 673 0
hScc1 G2GSE9613 54085574 54086075 501 0
p63 ME180GSE6132 54059975 54060286 311 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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