AutismKB 2.0

Annotation Detail for CIC


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Basic Information Top
Gene Symbol:CIC ( KIAA0306 )
Gene Full Name: capicua homolog (Drosophila)
Band: 19q13.2
Quick LinksEntrez ID:23152; OMIM: 612082; Uniprot ID:CIC_HUMAN; ENSEMBL ID: ENSG00000079432; HGNC ID: 14214
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
142Phosphoserine.
146Phosphoserine.
173Phosphoserine.
279Phosphoserine.
496Phosphoserine.
721Phosphoserine.
904Phosphoserine (By similarity).
1291Phosphothreonine.
1294Phosphoserine.
1373Phosphoserine.
1378Phosphoserine.
1382Phosphoserine.
1397Phosphoserine.
1402Phosphoserine.
1409Phosphoserine.
1462Phosphoserine.
Location(AA) Modifications Resource
279Phosphoserine.Swiss-Prot 53.0
279PhosphoserinePhospho.ELM 6.0
902PhosphoserinePhospho.ELM 6.0
904Phosphoserine (By similarity).Swiss-Prot 53.0
1373PhosphoserinePhospho.ELM 6.0
1375PhosphothreoninePhospho.ELM 6.0
1382PhosphoserinePhospho.ELM 6.0
1397PhosphoserinePhospho.ELM 6.0
1397Phosphoserine.Swiss-Prot 53.0
1409Phosphoserine.Swiss-Prot 53.0
1409PhosphoserinePhospho.ELM 6.0
1462Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
47Phosphoserine(ATM)HMM predict
52O-linkedHMM predict
52Phosphoserine(ATM)HMM predict
56Phosphoserine(IKK)HMM predict
68O-linkedHMM predict
69N-linkedHMM predict
132O-linkedHMM predict
132Phosphoserine(ATM)HMM predict
142Phosphoserine(CK1)HMM predict
142Phosphoserine(IKK)HMM predict
146Phosphoserine(ATM)HMM predict
171Phosphothreonine(PKA)HMM predict
173Phosphoserine(CAMK2)HMM predict
173Phosphoserine(IKK)HMM predict
183Phosphoserine(CK1)HMM predict
184Phosphoserine(CK1)HMM predict
185Phosphoserine(CK1)HMM predict
191Phosphoserine(CDK)HMM predict
227N-linkedHMM predict
249Phosphotyrosine(Syk)HMM predict
277Phosphoserine(PKG)HMM predict
278Phosphoserine(PKG)HMM predict
295Phosphothreonine(PKC)HMM predict
299Phosphoserine(IKK)HMM predict
299Phosphoserine(PKB)HMM predict
301Phosphoserine(CK1)HMM predict
301Phosphoserine(IKK)HMM predict
322Phosphothreonine(PKC)HMM predict
333O-linkedHMM predict
387Phosphoserine(IKK)HMM predict
395Phosphotyrosine(SRC)HMM predict
395Phosphotyrosine(Abl)HMM predict
426Phosphoserine(PKC)HMM predict
426Phosphoserine(ATM)HMM predict
431Phosphoserine(CAMK2)HMM predict
435Phosphothreonine(CK2)HMM predict
436Phosphoserine(CK2)HMM predict
474Phosphoserine(IKK)HMM predict
476Phosphoserine(CK2)HMM predict
476Phosphoserine(ATM)HMM predict
476Phosphoserine(IKK)HMM predict
480Phosphoserine(ATM)HMM predict
496Phosphoserine(CDC2)HMM predict
530O-linkedHMM predict
533O-linkedHMM predict
534O-linkedHMM predict
534Phosphoserine(IKK)HMM predict
535O-linkedHMM predict
538Phosphoserine(CDC2)HMM predict
538Phosphoserine(IKK)HMM predict
541Phosphoserine(CK2)HMM predict
542O-linkedHMM predict
545Phosphoserine(IKK)HMM predict
548O-linkedHMM predict
566Phosphoserine(IKK)HMM predict
567O-linkedHMM predict
583Phosphothreonine(MAPK)HMM predict
583Phosphothreonine(CDK)HMM predict
615O-linkedHMM predict
654O-linkedHMM predict
680O-linkedHMM predict
681O-linkedHMM predict
688O-linkedHMM predict
694Phosphoserine(CK2)HMM predict
700Phosphoserine(IKK)HMM predict
702N-linkedHMM predict
721Phosphoserine(CDC2)HMM predict
734Phosphoserine(IKK)HMM predict
738Phosphothreonine(PKC)HMM predict
739PhosphoserineHMM predict
790O-linkedHMM predict
854O-linkedHMM predict
854O-linkedHMM predict
861O-linkedHMM predict
894O-linkedHMM predict
904O-linkedHMM predict
934MethylarginineHMM predict
946O-linkedHMM predict
972O-linkedHMM predict
972Phosphoserine(IKK)HMM predict
975O-linkedHMM predict
982O-linkedHMM predict
982Phosphoserine(CDC2)HMM predict
982Phosphoserine(MAPK)HMM predict
990O-linkedHMM predict
991Phosphoserine(ATM)HMM predict
991Phosphoserine(IKK)HMM predict
1020Phosphoserine(CDC2)HMM predict
1020Phosphoserine(IKK)HMM predict
1024O-linkedHMM predict
1024O-linkedHMM predict
1024Phosphoserine(ATM)HMM predict
1028O-linkedHMM predict
1030O-linkedHMM predict
1031O-linkedHMM predict
1035O-linkedHMM predict
1048Phosphoserine(ATM)HMM predict
1073O-linkedHMM predict
1073Phosphoserine(CDC2)HMM predict
1077O-linkedHMM predict
1077Phosphoserine(CDC2)HMM predict
1099O-linkedHMM predict
1099Phosphoserine(CDC2)HMM predict
1103O-linkedHMM predict
1103Phosphothreonine(PKC)HMM predict
1104O-linkedHMM predict
1105O-linkedHMM predict
1112O-linkedHMM predict
1112Phosphoserine(ATM)HMM predict
1117O-linkedHMM predict
1121O-linkedHMM predict
1124O-linkedHMM predict
1125O-linkedHMM predict
1127Phosphothreonine(MAPK)HMM predict
1132O-linkedHMM predict
1132O-linkedHMM predict
1136O-linkedHMM predict
1143O-linkedHMM predict
1145O-linkedHMM predict
1145Phosphothreonine(MAPK)HMM predict
1149O-linkedHMM predict
1149Phosphothreonine(PKC)HMM predict
1150O-linkedHMM predict
1150Phosphoserine(CDC2)HMM predict
1154O-linkedHMM predict
1156O-linkedHMM predict
1173O-linkedHMM predict
1173Phosphoserine(CDC2)HMM predict
1240Phosphothreonine(MAPK)HMM predict
1246O-linkedHMM predict
1291Phosphothreonine(CDC2)HMM predict
1291Phosphothreonine(MAPK)HMM predict
1291Phosphothreonine(CDK)HMM predict
1294O-linkedHMM predict
1294Phosphoserine(CDC2)HMM predict
1310Phosphoserine(CK1)HMM predict
1311O-linkedHMM predict
1318Phosphothreonine(CDC2)HMM predict
1318Phosphothreonine(MAPK)HMM predict
1318Phosphothreonine(CDK)HMM predict
1318PhosphothreonineHMM predict
1327Phosphothreonine(PKC)HMM predict
1382Phosphoserine(CDC2)HMM predict
1396N-linkedHMM predict
1397Phosphoserine(PKG)HMM predict
1397PhosphoserineHMM predict
1402Phosphoserine(CK2)HMM predict
1409Phosphoserine(CDC2)HMM predict
1409Phosphoserine(MAPK)HMM predict
1409Phosphoserine(CDK)HMM predict
1418Phosphoserine(IKK)HMM predict
1419Phosphoserine(PKG)HMM predict
1419Phosphoserine(IKK)HMM predict
1419Phosphoserine(PKB)HMM predict
1422Phosphoserine(CK1)HMM predict
1422Phosphoserine(IKK)HMM predict
1426Phosphothreonine(CDC2)HMM predict
1426Phosphothreonine(MAPK)HMM predict
1455Phosphotyrosine(EGFR)HMM predict
1455Phosphotyrosine(Syk)HMM predict
1523Phosphothreonine(MAPK)HMM predict
1543O-linkedHMM predict
1550O-linkedHMM predict
1550O-linkedHMM predict
1550O-linkedHMM predict
1550Phosphothreonine(MAPK)HMM predict
1552O-linkedHMM predict
1552Phosphoserine(CDC2)HMM predict
1552Phosphoserine(CDK)HMM predict
1560O-linkedHMM predict
1560O-linkedHMM predict
1561O-linkedHMM predict
1561Phosphoserine(MAPK)HMM predict
1561Phosphoserine(IKK)HMM predict
1564O-linkedHMM predict
1566O-linkedHMM predict
1566Phosphoserine(CK1)HMM predict
1566Phosphoserine(IKK)HMM predict
1595O-linkedHMM predict
1595Phosphoserine(ATM)HMM predict
1602O-linkedHMM predict
1602O-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015125
  • Location:chr19 47480656-47491788
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 47475734 47476062 328 4759
CTCF CD4SISSRdata 47475734 47476062 328 4759
CTCF G2GSE9613 47471256 47471493 237 9282
CTCF G2GSE9613 47475644 47476162 518 4754
CTCF G2GSE9613 47478884 47479119 235 1655
Fos K562GSE19551 47476146 47476885 739 4141
H3ac HepG2E 47465630 47467184 1554 14250
H3ac HepG2E 47477770 47479599 1829 1972
LIN9 G0GSE7516 47476081 47476657 576 4288
Rb QuiescentGSE19898 47476376 47476486 110 4226
Rb QuiescentGSE19898 47476825 47476960 135 3764
Rb SenescentGSE19898 47476239 47476638 399 4218
Rb SenescentGSE19898 47479380 47479633 253 1150
TFAP2C MCF7GSE21234 47476127 47476808 681 4189
TFAP2C MCF7GSE21234 47476816 47477823 1007 3337
TFAP2C MCF7GSE21234 47478920 47479760 840 1317
hScc1 BcellGSE12603 47468698 47469288 590 11664
hScc1 BcellGSE12603 47469572 47470408 836 10667
hScc1 BcellGSE12603 47475500 47477418 1918 4198
hScc1 CdLSGSE12603 47475425 47476766 1341 4561
p130 QuiescentGSE19898 47476290 47476596 306 4214
p130 SenescentGSE19898 47476263 47476578 315 4236
p130 shRbSenescentGSE19898 47476096 47476621 525 4298
p63 keratinocytesGSE17611 47466460 47467375 915 13739
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 47492113 47492391 278 464
CTCF CD4SISSRdata 47492113 47492391 278 464
VDR GM10861-UnstimGSE22484 47491236 47493246 2010 453
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 47489542 47489824 282 0
TFAP2C MCF7GSE21234 47483444 47483854 410 0
hScc1 BcellGSE12603 47482967 47483267 300 0
hScc1 BcellGSE12603 47486353 47487766 1413 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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