AutismKB 2.0

Annotation Detail for FLNA


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Basic Information Top
Gene Symbol:FLNA ( ABP-280,ABPX,DKFZp434P031,FLN,FLN1,FMD,MNS,NHBP,OPD,OPD1,OPD2 )
Gene Full Name: filamin A, alpha
Band: Xq28
Quick LinksEntrez ID:2316; OMIM: 300017; Uniprot ID:FLNA_HUMAN; ENSEMBL ID: ENSG00000196924; HGNC ID: 3754
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylserine.
373Phosphotyrosine.
504N6-acetyllysine.
508N6-acetyllysine.
700N6-acetyllysine.
781N6-acetyllysine.
837N6-acetyllysine.
891N6-acetyllysine.
994N6-acetyllysine.
1047Phosphotyrosine.
1081Phosphoserine.
1084Phosphoserine.
1089Phosphothreonine.
1286Phosphothreonine (By similarity).
1338Phosphoserine.
1459Phosphoserine.
1533Phosphoserine.
1538N6-acetyllysine.
1604Phosphotyrosine.
1630Phosphoserine.
2053Phosphoserine.
2152Phosphoserine.
2158Phosphoserine.
2284Phosphoserine.
2327Phosphoserine.
2388Phosphotyrosine.
2414Phosphoserine.
2510Phosphoserine.
2607N6-acetyllysine.
2621N6-acetyllysine.
Location(AA) Modifications Resource
2N-acetylserine.Swiss-Prot 53.0
1046PhosphotyrosinePhospho.ELM 6.0
1047Phosphotyrosine.Swiss-Prot 53.0
1083PhosphoserinePhospho.ELM 6.0
1084Phosphoserine.Swiss-Prot 53.0
1089Phosphothreonine.Swiss-Prot 53.0
1458PhosphoserinePhospho.ELM 6.0
1459Phosphoserine.Swiss-Prot 53.0
1533Phosphoserine.Swiss-Prot 53.0
2151Phosphoserine (PAK1;RSK
2152Phosphoserine.Swiss-Prot 53.0
2284Phosphoserine.Swiss-Prot 53.0
2327Phosphoserine.Swiss-Prot 53.0
2522Phosphoserine (CaM-KII
Location(AA) Modification Resource
6Phosphoserine(IKK)HMM predict
6PhosphoserineHMM predict
167Phosphothreonine(MAPK)HMM predict
262Phosphoserine(ATM)HMM predict
339N-linkedHMM predict
399N-linkedHMM predict
442Phosphotyrosine(EGFR)HMM predict
442Phosphotyrosine(INSR)HMM predict
446Phosphotyrosine(Syk)HMM predict
468Phosphoserine(CDC2)HMM predict
479N-linkedHMM predict
543Phosphotyrosine(Syk)HMM predict
564Phosphoserine(CDC2)HMM predict
643Phosphotyrosine(Abl)HMM predict
728N-linkedHMM predict
731Phosphotyrosine(Jak)HMM predict
731Phosphotyrosine(INSR)HMM predict
757Phosphoserine(CDC2)HMM predict
831N-linkedHMM predict
860Phosphoserine(CDC2)HMM predict
948N-linkedHMM predict
959Phosphoserine(CDC2)HMM predict
962O-linkedHMM predict
1012O-linkedHMM predict
1041Phosphotyrosine(Abl)HMM predict
1041Phosphotyrosine(SRC)HMM predict
1055Phosphoserine(CDC2)HMM predict
1065Phosphothreonine(PKC)HMM predict
1065O-linkedHMM predict
1081O-linkedHMM predict
1081O-linkedHMM predict
1148Phosphoserine(CDC2)HMM predict
1256Phosphoserine(IKK)HMM predict
1288O-linkedHMM predict
1299N-linkedHMM predict
1303N-linkedHMM predict
1322Phosphothreonine(MAPK)HMM predict
1342O-linkedHMM predict
1343Phosphoserine(CDC2)HMM predict
1350O-linkedHMM predict
1425N-linkedHMM predict
1436Phosphoserine(CDC2)HMM predict
1459O-linkedHMM predict
1533Phosphoserine(CDC2)HMM predict
1556N-linkedHMM predict
1604Phosphotyrosine(INSR)HMM predict
1630Phosphoserine(CDC2)HMM predict
1974N-linkedHMM predict
2016Phosphothreonine(PKC)HMM predict
2033O-linkedHMM predict
2033Phosphoserine(CDC2)HMM predict
2053Phosphoserine(PKG)HMM predict
2094Phosphothreonine(CK2)HMM predict
2105O-linkedHMM predict
2114Phosphotyrosine(INSR)HMM predict
2128Phosphoserine(CDC2)HMM predict
2143Phosphoserine(PKG)HMM predict
2152Phosphoserine(PKG)HMM predict
2152Phosphoserine(PKB)HMM predict
2180Phosphoserine(CDC2)HMM predict
2182O-linkedHMM predict
2195N-linkedHMM predict
2305Phosphotyrosine(INSR)HMM predict
2327Phosphoserine(MAPK)HMM predict
2327Phosphoserine(CDC2)HMM predict
2336Phosphothreonine(PKA)HMM predict
2336Phosphothreonine(PKC)HMM predict
2388Phosphotyrosine(Jak)HMM predict
2388Phosphotyrosine(Syk)HMM predict
2407N-linkedHMM predict
2414Phosphoserine(CDC2)HMM predict
2453N-linkedHMM predict
2456N-linkedHMM predict
2487Phosphotyrosine(INSR)HMM predict
2488O-linkedHMM predict
2510Phosphoserine(CDC2)HMM predict
2517Phosphothreonine(PKC)HMM predict
2524N-linkedHMM predict
2526Phosphoserine(CK1)HMM predict
2537O-linkedHMM predict
2579Phosphothreonine(PKC)HMM predict
2599Phosphothreonine(MAPK)HMM predict
2615Phosphoserine(PKA)HMM predict
2640Phosphoserine(CDC2)HMM predict
2642Phosphotyrosine(Abl)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001456
  • Location:chrX 153230090-153252844
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 153254715 153256819 2104 2923
NFkBII GM10847GSE19485 153252166 153253755 1589 116
NFkBII GM12892GSE19485 153250952 153254919 3967 91
PHF8 HeLaGSE20725 153252090 153254092 2002 247
hScc1 BcellGSE12603 153253150 153254065 915 763
hScc1 G2GSE9613 153253150 153253723 573 592
hScc1 G2GSE9613 153254566 153255627 1061 2252
hScc1 G2GSE9613 153256283 153256819 536 3707
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 153222869 153225080 2211 6116
CTCF G2GSE9613 153225463 153226354 891 4182
CTCF G2GSE9613 153226711 153227147 436 3162
CTCF G2GSE9613 153227595 153229133 1538 1727
ETS1 JurkatGSE17954 153223199 153223802 603 6590
Fos K562GSE19551 153223594 153223728 134 6430
TFAP2C MCF7GSE21234 153224126 153224830 704 5613
hScc1 BcellGSE12603 153222698 153223709 1011 6887
hScc1 BcellGSE12603 153225463 153225772 309 4473
hScc1 G2GSE9613 153222904 153225080 2176 6099
hScc1 G2GSE9613 153225463 153225664 201 4527
hScc1 G2GSE9613 153226747 153227070 323 3182
hScc1 G2GSE9613 153227532 153228012 480 2319
hScc1 G2GSE9613 153228570 153228975 405 1318
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 153229764 153230442 678 0
CTCF G2GSE9613 153230874 153232608 1734 0
CTCF G2GSE9613 153232898 153233892 994 0
CTCF G2GSE9613 153234425 153240007 5582 0
CTCF G2GSE9613 153240254 153242300 2046 0
CTCF G2GSE9613 153242972 153243150 178 0
CTCF G2GSE9613 153243802 153244032 230 0
CTCF G2GSE9613 153245752 153247166 1414 0
CTCF G2GSE9613 153247605 153248612 1007 0
CTCF G2GSE9613 153249086 153253912 4826 0
PHF8 293TGSE20725 153252175 153253240 1065 0
Pol2 GM12878GSE19551 153252413 153252954 541 0
PolII HeLaGSE12783 153245226 153254340 9114 0
TFAP2C MCF7GSE21234 153239582 153240179 597 0
TFAP2C MCF7GSE21234 153250394 153251505 1111 0
hScc1 BcellGSE12603 153231766 153232023 257 0
hScc1 BcellGSE12603 153236893 153239101 2208 0
hScc1 BcellGSE12603 153240112 153241224 1112 0
hScc1 BcellGSE12603 153251775 153252905 1130 0
hScc1 CdLSGSE12603 153252247 153253077 830 0
hScc1 G2GSE9613 153232827 153233634 807 0
hScc1 G2GSE9613 153235222 153235738 516 0
hScc1 G2GSE9613 153236605 153237777 1172 0
hScc1 G2GSE9613 153238053 153239865 1812 0
hScc1 G2GSE9613 153241045 153241261 216 0
hScc1 G2GSE9613 153246373 153247058 685 0
hScc1 G2GSE9613 153247641 153248074 433 0
hScc1 G2GSE9613 153249156 153249770 614 0
hScc1 G2GSE9613 153250148 153251277 1129 0
hScc1 G2GSE9613 153251942 153252905 963 0
p130 QuiescentGSE19898 153250659 153250875 216 0
p130 QuiescentGSE19898 153251524 153251851 327 0
p130 SenescentGSE19898 153250655 153250977 322 0
p130 shRbQuiescentGSE19898 153250185 153250678 493 0
p130 shRbQuiescentGSE19898 153250700 153251086 386 0
p130 shRbQuiescentGSE19898 153251238 153251802 564 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
28318 EST chrX 153097279 153098600 461 mRNA FLNA chrX 153097811 153123776Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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