AutismKB 2.0

Annotation Detail for FLNB


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Basic Information Top
Gene Symbol:FLNB ( ABP-278,ABP-280,AOI,DKFZp686A1668,DKFZp686O033,FH1,FLN1L,LRS1,SCT,TABP,TAP )
Gene Full Name: filamin B, beta
Band: 3p14.3
Quick LinksEntrez ID:2317; OMIM: 603381; Uniprot ID:FLNB_HUMAN; ENSEMBL ID: ENSG00000136068; HGNC ID: 3755
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
519Phosphothreonine.
658Phosphoserine.
681N6-acetyllysine.
886Phosphoserine.
983Phosphoserine.
1028Phosphoserine.
1316Phosphoserine.
1433Phosphoserine.
1505Phosphoserine.
1530Phosphotyrosine.
1557Phosphothreonine (By similarity).
1602Phosphoserine.
1684Phosphotyrosine.
2083Phosphoserine.
2107Phosphoserine.
2170N6-acetyllysine.
2369Phosphoserine.
2478Phosphoserine.
2481Phosphoserine.
2502Phosphotyrosine.
2576N6-acetyllysine.
Location(AA) Modifications Resource
567PhosphoserinePhospho.ELM 6.0
983Phosphoserine.Swiss-Prot 53.0
1937PhosphoserinePhospho.ELM 6.0
2502Phosphotyrosine.Swiss-Prot 53.0
2502PhosphotyrosinePhospho.ELM 6.0
Location(AA) Modification Resource
140Phosphothreonine(MAPK)HMM predict
235Phosphoserine(ATM)HMM predict
306Phosphothreonine(MAPK)HMM predict
312N-linkedHMM predict
315Phosphotyrosine(INSR)HMM predict
315Phosphotyrosine(SRC)HMM predict
376Phosphotyrosine(INSR)HMM predict
414Phosphotyrosine(EGFR)HMM predict
418Phosphotyrosine(Syk)HMM predict
440Phosphoserine(CDC2)HMM predict
472Phosphothreonine(PKA)HMM predict
515Phosphotyrosine(Jak)HMM predict
516Phosphotyrosine(EGFR)HMM predict
516SulfotyrosineHMM predict
537Phosphoserine(CDC2)HMM predict
577Phosphoserine(CK1)HMM predict
590Phosphoserine(ATM)HMM predict
616Phosphotyrosine(INSR)HMM predict
616Phosphotyrosine(Abl)HMM predict
709O-linkedHMM predict
709Phosphothreonine(CDK)HMM predict
730Phosphoserine(CDC2)HMM predict
789Phosphoserine(CAMK2)HMM predict
789Phosphoserine(CK1)HMM predict
804N-linkedHMM predict
833Phosphoserine(CDC2)HMM predict
886Phosphoserine(CDC2)HMM predict
904Phosphotyrosine(Jak)HMM predict
904SulfotyrosineHMM predict
911Phosphothreonine(MAPK)HMM predict
932Phosphoserine(CDC2)HMM predict
983Phosphoserine(CDC2)HMM predict
983Phosphoserine(CDK)HMM predict
994Phosphothreonine(CDK)HMM predict
1001N-linkedHMM predict
1014Phosphotyrosine(Abl)HMM predict
1028Phosphoserine(CDC2)HMM predict
1035O-linkedHMM predict
1121Phosphoserine(CDC2)HMM predict
1157N-linkedHMM predict
1190Phosphotyrosine(INSR)HMM predict
1193O-linkedHMM predict
1248Phosphothreonine(PKA)HMM predict
1272N-linkedHMM predict
1316Phosphoserine(CDC2)HMM predict
1398N-linkedHMM predict
1409Phosphoserine(CDC2)HMM predict
1482O-linkedHMM predict
1484O-linkedHMM predict
1484Phosphothreonine(MAPK)HMM predict
1484Phosphothreonine(CDK)HMM predict
1486Phosphoserine(ATM)HMM predict
1491Phosphotyrosine(SRC)HMM predict
1505Phosphoserine(CDC2)HMM predict
1530Phosphotyrosine(INSR)HMM predict
1576Phosphotyrosine(INSR)HMM predict
1602Phosphoserine(CDC2)HMM predict
1609Phosphothreonine(PKA)HMM predict
1630Phosphothreonine(CK2)HMM predict
1698Phosphoserine(CDC2)HMM predict
1729Phosphothreonine(PKC)HMM predict
1733Phosphotyrosine(INSR)HMM predict
1733Phosphotyrosine(SRC)HMM predict
1737O-linkedHMM predict
1768O-linkedHMM predict
1773Phosphothreonine(MAPK)HMM predict
1837N-linkedHMM predict
1879O-linkedHMM predict
1916Phosphoserine(PKG)HMM predict
1988Phosphoserine(CDC2)HMM predict
2049Phosphothreonine(CK2)HMM predict
2086Phosphothreonine(PKC)HMM predict
2098Phosphoserine(PKG)HMM predict
2107O-linkedHMM predict
2107Phosphoserine(PKG)HMM predict
2107Phosphoserine(IKK)HMM predict
2125N-linkedHMM predict
2135Phosphoserine(CDC2)HMM predict
2141Phosphothreonine(PKC)HMM predict
2260Phosphotyrosine(INSR)HMM predict
2276Phosphotyrosine(SRC)HMM predict
2276Phosphotyrosine(Abl)HMM predict
2276Phosphotyrosine(Syk)HMM predict
2291Phosphothreonine(PKC)HMM predict
2343Phosphotyrosine(Jak)HMM predict
2343Phosphotyrosine(Syk)HMM predict
2362N-linkedHMM predict
2369Phosphoserine(CDC2)HMM predict
2408N-linkedHMM predict
2420O-linkedHMM predict
2434Phosphothreonine(CDC2)HMM predict
2438Phosphotyrosine(INSR)HMM predict
2438Phosphotyrosine(Syk)HMM predict
2465Phosphoserine(CDC2)HMM predict
2478Phosphoserine(CDC2)HMM predict
2483N-linkedHMM predict
2496Phosphoserine(IKK)HMM predict
2498Phosphothreonine(PKC)HMM predict
2500O-linkedHMM predict
2502Phosphotyrosine(SRC)HMM predict
2510Phosphoserine(CK2)HMM predict
2513Phosphoserine(IKK)HMM predict
2554Phosphothreonine(MAPK)HMM predict
2569Phosphotyrosine(SRC)HMM predict
2569Phosphotyrosine(Syk)HMM predict
2570N-linkedHMM predict
2581Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_001457
  • Location:chr3 57969166-58133014
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 57968958 57969255 297 60
CTCF CD4SISSRdata 57968958 57969255 297 60
CTCF JurkatGSE12889 57968912 57969139 227 141
FoxA1 MCF7MACSdata 57960299 57960497 198 8769
RARG MCF7GSE15244 57959434 57959678 244 9611
hScc1 CdLSGSE12603 57968668 57969580 912 43
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 58138508 58138780 272 5630
CTCF CD4SISSRdata 58138508 58138780 272 5630
CTCF JurkatGSE12889 58138465 58138775 310 5606
CTCF G2GSE9613 58134361 58135303 942 1818
CTCF G2GSE9613 58138975 58139224 249 6085
CTCF G2GSE9613 58139622 58140111 489 6852
CTCF G2GSE9613 58140879 58141458 579 8154
FOXA1 MCF7GSE15244 58141983 58142308 325 9131
H3ac HepG2E 58136609 58137018 409 3799
TFAP2C MCF7GSE21234 58139758 58140223 465 6976
hScc1 BcellGSE12603 58134424 58134849 425 1622
hScc1 CdLSGSE12603 58134391 58134982 591 1672
hScc1 CdLSGSE12603 58138440 58139542 1102 5977
hScc1 G2GSE9613 58136842 58137018 176 3916
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 58122401 58123137 736 0
CTCF CD4GSE12889 58128121 58128432 311 0
CTCF CD4SISSRdata 58128121 58128432 311 0
CTCF HelaGSE12889 58128181 58128530 349 0
CTCF JurkatGSE12889 58128175 58128403 228 0
CTCF G2GSE9613 57968668 57970307 1639 0
CTCF G2GSE9613 58036163 58036796 633 0
CTCF G2GSE9613 58052448 58052624 176 0
CTCF G2GSE9613 58059409 58059706 297 0
CTCF G2GSE9613 58104620 58104917 297 0
CTCF G2GSE9613 58114122 58114349 227 0
CTCF G2GSE9613 58121770 58121987 217 0
CTCF G2GSE9613 58128300 58129106 806 0
ER E2-MCF7GSE14664 58063650 58063688 38 0
ER MCF7GSE19013 58000687 58001313 626 0
ER MCF7GSE19013 58002239 58002735 496 0
ER MCF7GSE19013 58013245 58013764 519 0
ER MCF7GSE19013 58020218 58020724 506 0
ER MCF7GSE19013 58057494 58058113 619 0
ER MCF7GSE19013 58062641 58063170 529 0
ER MCF7GSE19013 58063606 58064158 552 0
FOXA1 MCF7GSE15244 57986817 57987899 1082 0
FOXA1 MCF7GSE15244 58000237 58000598 361 0
FOXA1 MCF7GSE15244 58000918 58001231 313 0
FOXA1 MCF7GSE15244 58004598 58005058 460 0
FOXA1 MCF7GSE15244 58012179 58012599 420 0
FOXA1 MCF7GSE15244 58012958 58013693 735 0
FOXA1 MCF7GSE15244 58063822 58064141 319 0
FOXA1 MCF7GSE15244 58080722 58082203 1481 0
FOXA1 MCF7GSE15244 58105764 58105926 162 0
Fos K562GSE19551 58012981 58013565 584 0
FoxA1 MCF7MACSdata 57971475 57971623 148 0
FoxA1 MCF7MACSdata 58000889 58001151 262 0
FoxA1 MCF7MACSdata 58004718 58004922 204 0
FoxA1 MCF7MACSdata 58020318 58020518 200 0
H3ac HepG2E 57969834 57971233 1399 0
H3ac HepG2E 57972079 57972563 484 0
H3ac HepG2E 57985194 57985439 245 0
H3ac HepG2E 58011105 58011533 428 0
H3ac HepG2E 58011898 58012599 701 0
H3ac HepG2E 58013353 58013693 340 0
Myc K562GSE19551 58068396 58068618 222 0
Myc K562GSE19551 58122407 58123127 720 0
Myc K562GSE19551 58128170 58128521 351 0
Myc hESGSE17917 57981083 57981318 235 0
NFkBII GM10847GSE19485 58076499 58077951 1452 0
NFkBII GM12878GSE19485 57994862 57996839 1977 0
NFkBII GM12878GSE19485 58076579 58078420 1841 0
NFkBII GM12892GSE19485 58071940 58073557 1617 0
Oct1 HelaGSE14283 58050436 58050500 64 0
Oct1 HelaGSE14283 58063648 58063737 89 0
Oct1 HelaGSE14283 58093352 58093395 43 0
Oct1 HelaGSE14283 58102406 58102436 30 0
PHF8 293TGSE20725 57968870 57969732 862 0
RARA MCF7GSE15244 58012248 58012599 351 0
RARA MCF7GSE15244 58012958 58013693 735 0
RARA MCF7GSE15244 58057576 58058136 560 0
RARG MCF7GSE15244 57986817 57987769 952 0
RARG MCF7GSE15244 58000237 58000598 361 0
RARG MCF7GSE15244 58012212 58012599 387 0
RARG MCF7GSE15244 58012958 58013693 735 0
RARG MCF7GSE15244 58032397 58033284 887 0
RARG MCF7GSE15244 58057576 58058097 521 0
RARG MCF7GSE15244 58063822 58064248 426 0
SRF HelaGSE8489 58018872 58020916 2044 0
SRF HelaGSE8489 58021602 58022190 588 0
SRF k562GSE8489 58018872 58020916 2044 0
SRF k562GSE8489 58021602 58022190 588 0
STAT1 HeLaGSE12783 58121630 58123426 1796 0
TFAP2C MCF7GSE21234 57970904 57971349 445 0
TFAP2C MCF7GSE21234 58002229 58002633 404 0
TFAP2C MCF7GSE21234 58009927 58010619 692 0
TFAP2C MCF7GSE21234 58021364 58021921 557 0
TFAP2C MCF7GSE21234 58063774 58064257 483 0
USF2 HepG2E 58019651 58020916 1265 0
hScc1 BcellGSE12603 57968668 57970503 1835 0
hScc1 BcellGSE12603 58102894 58103323 429 0
hScc1 BcellGSE12603 58104331 58104790 459 0
hScc1 G2GSE9613 57968668 57970388 1720 0
hScc1 G2GSE9613 58128335 58129037 702 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
18204 mRNA FLNB chr3 57969200 58133015 221 mRNA chr3 58123316 58131385Sense/Antisense (SA) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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