Annotation Detail for METAP1

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Basic Information Top

Gene Symbol:	METAP1 ( DKFZp781C0419,KIAA0094,MAP1A,MetAP1A )
Gene Full Name:	methionyl aminopeptidase 1
Band:	4q23
Quick Links	Entrez ID:23173; OMIM: 610151; Uniprot ID:AMPM1_HUMAN; ENSEMBL ID: ENSG00000164024; HGNC ID: 15789
Relate to Another Database:	SFARIGene; denovo-db

Pathways, Diseases and Drugs

TF binding site

Post Translation Modification

PTM Sites from Uniprot:2 results
Experimental PTM Sites from dbPTM:1 results
Predicted PTM Sites by profile HMM from dbPTM:3 results

Location(AA)	Modification
2	N-acetylalanine.
253	Phosphotyrosine.

Validated transcription factor binding site by ChIP-Chip and ChIP-Seq

RefSeq ID: NM_015143
Location:chr4 100175619-100202981
strand:+

Upstream the gene:4 results
Downstream the gene:2 results
Inside the gene:9 results

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	G2	GSE9613	100162501	100163223	722	12758
H3ac	HepG2	E	100162742	100163259	517	12619
Oct1	Hela	GSE14283	100170101	100170139	38	5500
RNAII	Tamoxifen-MCF7	GSE14664	100170098	100170139	41	5501

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
Oct1	H2O2-Hela	GSE14283	100206025	100206059	34	3061
Oct1	Hela	GSE14283	100206019	100206058	39	3057

Transcrip Factors	Experimental Cell	Database	TF Binding Start	TF Binding End	TF Binding Length	The Distance to Gene
CTCF	CD4	GSE12889	100196210	100196625	415	0
CTCF	CD4	SISSRdata	100196210	100196625	415	0
CTCF	Hela	GSE12889	100196298	100196591	293	0
CTCF	G2	GSE9613	100190525	100190689	164	0
CTCF	G2	GSE9613	100196227	100196601	374	0
Myc	K562	GSE19551	100196240	100196507	267	0
Rb	Quiescent	GSE19898	100201522	100201698	176	0
Sox2	hES	GSE18292	100196124	100196482	358	0
hScc1	Bcell	GSE12603	100196191	100196561	370	0

Validated miRNA targets

Cis-Nats regulation

Simple Query:

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

Studies: 1,036
Genes: 1,379
CNVs/SVs: 5,420
SNVs/Indels: 11,669
de novo Mutations: 5,669
Mosaics: 789
Linkage Regions: 172

Paper Collected: 6/30/2018

Last Update: 8/26/2018

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