AutismKB 2.0

Annotation Detail for LPIN1


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Basic Information Top
Gene Symbol:LPIN1 ( DKFZp781P1796,KIAA0188,PAP1 )
Gene Full Name: lipin 1
Band: 2p25.1
Quick LinksEntrez ID:23175; OMIM: 605518; Uniprot ID:LPIN1_HUMAN; ENSEMBL ID: ENSG00000134324; HGNC ID: 13345
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
106Phosphoserine (By similarity).
150Phosphoserine (By similarity).
158Nuclear localization signal (Potential).
252Phosphoserine (By similarity).
254Phosphoserine (By similarity).
260Phosphoserine (By similarity).
264Phosphothreonine (By similarity).
294Phosphoserine (By similarity).
434Phosphoserine (By similarity).
438Phosphoserine (By similarity).
449Phosphoserine (By similarity).
600Phosphoserine (By similarity).
601Phosphoserine (By similarity).
682DXDXT motif.
693LXXIL motif.
887Phosphoserine (By similarity).
889Phosphoserine (By similarity).
Location(AA) Modifications Resource
Location(AA) Modification Resource
143O-linkedHMM predict
145Phosphothreonine(MAPK)HMM predict
145Phosphothreonine(CDK)HMM predict
145O-linkedHMM predict
147Phosphoserine(CK1)HMM predict
147O-linkedHMM predict
148O-linkedHMM predict
162Phosphoserine(PKA)HMM predict
162Phosphoserine(PKC)HMM predict
162Phosphoserine(PKG)HMM predict
162Phosphoserine(IKK)HMM predict
174N-linkedHMM predict
176Phosphoserine(CK2)HMM predict
188Phosphoserine(ATM)HMM predict
228Phosphoserine(IKK)HMM predict
228Phosphoserine(PKB)HMM predict
237Phosphoserine(IKK)HMM predict
239Phosphothreonine(CDK)HMM predict
239Phosphothreonine(MAPK)HMM predict
239O-linkedHMM predict
241Phosphoserine(CDK)HMM predict
241Phosphoserine(CDC2)HMM predict
245O-linkedHMM predict
245O-linkedHMM predict
249Phosphothreonine(CDC2)HMM predict
249Phosphothreonine(CDK)HMM predict
249Phosphothreonine(MAPK)HMM predict
286Phosphoserine(CDC2)HMM predict
294Phosphoserine(IKK)HMM predict
297Phosphoserine(CDC2)HMM predict
315Phosphoserine(CK1)HMM predict
319Phosphoserine(ATM)HMM predict
376N-linkedHMM predict
380Phosphoserine(CDC2)HMM predict
436N-linkedHMM predict
441Phosphoserine(ATM)HMM predict
441Phosphoserine(IKK)HMM predict
449O-linkedHMM predict
454Phosphothreonine(CK2)HMM predict
515N-linkedHMM predict
561N-linkedHMM predict
568Phosphoserine(CK2)HMM predict
598Phosphoserine(CK2)HMM predict
599Phosphoserine(CK1)HMM predict
600Phosphoserine(CK2)HMM predict
600Phosphoserine(CK1)HMM predict
601Phosphoserine(CK2)HMM predict
601Phosphoserine(ATM)HMM predict
601Phosphoserine(CK1)HMM predict
688Phosphothreonine(PKC)HMM predict
717Phosphotyrosine(Syk)HMM predict
755Phosphoserine(CDC2)HMM predict
755Phosphoserine(MAPK)HMM predict
806Phosphotyrosine(Abl)HMM predict
820Phosphothreonine(PKC)HMM predict
835N-linkedHMM predict
869N-linkedHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_145693
  • Location:chr2 11804190-11884981
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 11796170 11796352 182 7930
CTCF CD4SISSRdata 11796170 11796352 182 7930
CTCF G2GSE9613 11802500 11802966 466 1458
Gata2 K562GSE18868 11802499 11803141 642 1371
P300 T30-glioblastomaGSE21026 11801385 11802358 973 2319
TFAP2C MCF7GSE21234 11796085 11797105 1020 7596
p130 SenescentGSE19898 11796136 11796327 191 7959
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 11886753 11887099 346 1945
CTCF CD4SISSRdata 11886753 11887099 346 1945
CTCF G2GSE9613 11886766 11888080 1314 2442
CTCF G2GSE9613 11895375 11896469 1094 10941
H3ac HepG2E 11887430 11888080 650 2774
Nanog hESGSE18292 11887667 11888090 423 2897
P300 T30-glioblastomaGSE21026 11886836 11888623 1787 2748
USF2 HepG2E 11887466 11888080 614 2792
VDR GM10855-stimGSE22484 11886377 11889005 2628 2710
hScc1 BcellGSE12603 11886720 11888006 1286 2382
hScc1 BcellGSE12603 11894468 11894795 327 9650
hScc1 CdLSGSE12603 11886720 11888189 1469 2473
hScc1 G2GSE9613 11886766 11888189 1423 2496
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 11836727 11837081 354 0
CTCF CD4GSE12889 11842613 11842796 183 0
CTCF CD4SISSRdata 11836727 11837081 354 0
CTCF CD4SISSRdata 11842613 11842796 183 0
CTCF G2GSE9613 11804095 11804845 750 0
CTCF G2GSE9613 11810324 11810623 299 0
CTCF G2GSE9613 11820694 11821046 352 0
CTCF G2GSE9613 11822605 11822877 272 0
CTCF G2GSE9613 11836515 11837248 733 0
CTCF G2GSE9613 11841918 11843614 1696 0
CTCF G2GSE9613 11846310 11846794 484 0
CTCF G2GSE9613 11854131 11854389 258 0
CTCF G2GSE9613 11871521 11871787 266 0
CTCF G2GSE9613 11872037 11872565 528 0
ER MCF7GSE19013 11845655 11846994 1339 0
FOXA1 MCF7GSE15244 11880316 11880997 681 0
FoxA1 MCF7MACSdata 11818853 11819151 298 0
FoxA1 MCF7MACSdata 11880407 11880609 202 0
H3K4me2 HCT116GSE10453 11804919 11805429 510 0
H3ac HepG2E 11804883 11806725 1842 0
KLF4 hESGSE17917 11804117 11804410 293 0
Myc K562GSE19551 11836617 11837155 538 0
NRSF JurkatGSE13047 11867462 11867955 493 0
NRSF-mono JurkatQuESTdata 11867476 11867883 407 0
NRSF-poly JurkatQuESTdata 11867411 11868009 598 0
Rb SenescentGSE19898 11836669 11837117 448 0
TAF HelaGSE8489 11804883 11805391 508 0
TAF k562GSE8489 11804682 11805391 709 0
TFAP2C MCF7GSE21234 11821778 11822531 753 0
TFAP2C MCF7GSE21234 11865088 11865543 455 0
TFAP2C MCF7GSE21234 11880340 11880876 536 0
hScc1 BcellGSE12603 11804019 11804682 663 0
hScc1 BcellGSE12603 11836473 11837212 739 0
hScc1 BcellGSE12603 11842275 11842894 619 0
hScc1 CdLSGSE12603 11836589 11837428 839 0
hScc1 G2GSE9613 11836552 11837248 696 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-miR-143 hsa-mir-143 5 20064147
hsa-miR-143* hsa-mir-143 5 20064147
No data
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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