AutismKB 2.0

Annotation Detail for PHLDB1


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Basic Information Top
Gene Symbol:PHLDB1 ( DKFZp686H039,DKFZp686O24210,FLJ00141,FLJ90266,KIAA0638,LL5A,MGC111531 )
Gene Full Name: pleckstrin homology-like domain, family B, member 1
Band: 11q23.3
Quick LinksEntrez ID:23187; OMIM: 612834; Uniprot ID:PHLB1_HUMAN; ENSEMBL ID: ENSG00000019144; HGNC ID: 23697
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
220Phosphoserine.
223Phosphoserine.
324Phosphoserine.
430Phosphoserine.
443Phosphoserine.
501Phosphoserine.
516Phosphothreonine.
518Phosphoserine.
520Phosphoserine.
539Phosphoserine.
551Phosphoserine.
555Phosphoserine.
563Phosphoserine (By similarity).
583Phosphoserine.
Location(AA) Modifications Resource
324Phosphoserine.Swiss-Prot 53.0
518Phosphoserine (By similarity).Swiss-Prot 53.0
583Phosphoserine.Swiss-Prot 53.0
Location(AA) Modification Resource
114Phosphothreonine(PKA)HMM predict
123S-palmitoylHMM predict
156Phosphotyrosine(SRC)HMM predict
156Phosphotyrosine(Abl)HMM predict
157O-linkedHMM predict
165Phosphoserine(CK1)HMM predict
170N-linkedHMM predict
181O-linkedHMM predict
181Phosphoserine(PKB)HMM predict
215O-linkedHMM predict
220Phosphoserine(CDC2)HMM predict
220Phosphoserine(MAPK)HMM predict
220Phosphoserine(CDK)HMM predict
220Phosphoserine(IKK)HMM predict
234O-linkedHMM predict
234Phosphoserine(CDC2)HMM predict
234Phosphoserine(MAPK)HMM predict
234Phosphoserine(ATM)HMM predict
238Phosphoserine(CDC2)HMM predict
238Phosphoserine(MAPK)HMM predict
238Phosphoserine(ATM)HMM predict
238PhosphoserineHMM predict
250N-linkedHMM predict
251O-linkedHMM predict
252O-linkedHMM predict
252Phosphoserine(CDC2)HMM predict
256O-linkedHMM predict
256Phosphoserine(CDC2)HMM predict
259O-linkedHMM predict
260Phosphoserine(CDC2)HMM predict
260Phosphoserine(CDK)HMM predict
264O-linkedHMM predict
266Phosphoserine(IKK)HMM predict
269O-linkedHMM predict
271Phosphoserine(IKK)HMM predict
273O-linkedHMM predict
280O-linkedHMM predict
291Phosphoserine(PKB)HMM predict
304O-linkedHMM predict
310Phosphoserine(IKK)HMM predict
324Phosphoserine(CDC2)HMM predict
324Phosphoserine(CDK)HMM predict
324PhosphoserineHMM predict
334Phosphoserine(CDC2)HMM predict
334Phosphoserine(IKK)HMM predict
338O-linkedHMM predict
347Phosphothreonine(PKA)HMM predict
347Phosphothreonine(PKC)HMM predict
362Phosphoserine(PKG)HMM predict
369O-linkedHMM predict
373Phosphoserine(ATM)HMM predict
373Phosphoserine(IKK)HMM predict
376O-linkedHMM predict
377Phosphoserine(IKK)HMM predict
381O-linkedHMM predict
381Phosphoserine(CDC2)HMM predict
404Phosphoserine(CDC2)HMM predict
417Phosphothreonine(PKC)HMM predict
419Phosphoserine(CDC2)HMM predict
419Phosphoserine(CDK)HMM predict
461Phosphoserine(MAPK)HMM predict
461Phosphoserine(CDK)HMM predict
470Phosphoserine(PKG)HMM predict
470Phosphoserine(CDC2)HMM predict
474O-linkedHMM predict
477Phosphothreonine(CDC2)HMM predict
489Phosphoserine(CDC2)HMM predict
489Phosphoserine(CDK)HMM predict
489PhosphoserineHMM predict
518Phosphoserine(CDC2)HMM predict
518Phosphoserine(CDK)HMM predict
518Phosphoserine(IKK)HMM predict
518Phosphoserine(PKB)HMM predict
522Phosphothreonine(PKC)HMM predict
539Phosphoserine(CDC2)HMM predict
563Phosphoserine(PKG)HMM predict
578Phosphoserine(PKG)HMM predict
578Phosphoserine(CK1)HMM predict
583Phosphoserine(CK2)HMM predict
665Phosphoserine(PKG)HMM predict
665PhosphoserineHMM predict
682Phosphoserine(CK1)HMM predict
692Phosphoserine(CK1)HMM predict
693Phosphoserine(CK1)HMM predict
693Phosphoserine(IKK)HMM predict
697PhosphothreonineHMM predict
706Phosphoserine(CK1)HMM predict
942Phosphoserine(CDK)HMM predict
942Phosphoserine(IKK)HMM predict
945O-linkedHMM predict
945Phosphoserine(IKK)HMM predict
946O-linkedHMM predict
946Phosphoserine(ATM)HMM predict
971Phosphoserine(CDC2)HMM predict
971Phosphoserine(CDK)HMM predict
978Phosphoserine(IKK)HMM predict
992Phosphoserine(CK1)HMM predict
992Phosphoserine(IKK)HMM predict
1002Phosphoserine(CDC2)HMM predict
1002Phosphoserine(CDK)HMM predict
1004Phosphoserine(CDC2)HMM predict
1007Phosphoserine(IKK)HMM predict
1013N-linkedHMM predict
1109Phosphotyrosine(INSR)HMM predict
1109Phosphotyrosine(Syk)HMM predict
1119Phosphoserine(CK1)HMM predict
1119Phosphoserine(IKK)HMM predict
1136N-linkedHMM predict
1141Phosphoserine(IKK)HMM predict
1196Phosphoserine(CAMK2)HMM predict
1312SulfotyrosineHMM predict
1327Phosphothreonine(PKA)HMM predict
1372Phosphotyrosine(Abl)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015157
  • Location:chr11 117982422-118033950
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
p130 shRbQuiescentGSE19898 117981183 117981944 761 859
p130 shRbSenescentGSE19898 117981416 117981776 360 827
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 117983431 117985401 1970 0
CTCF CD4GSE12889 117986972 117987284 312 0
CTCF CD4SISSRdata 117986972 117987284 312 0
FOXA1 MCF7GSE15244 117999352 117999725 373 0
H3K27me3 colorectalcancer 117982466 117983229 763 0
H3ac HepG2E 117984677 117985509 832 0
H3ac HepG2E 117997592 117999725 2133 0
KLF4 hESGSE17917 118010748 118011140 392 0
Myc K562GSE19551 118005122 118005331 209 0
NRSF pAbJurkat 117984607 117985875 1268 0
NRSF pAbJurkat 117996809 117997451 642 0
NRSF pAbJurkat 118006506 118006819 313 0
NRSF pAbJurkat 118010474 118011217 743 0
NRSF pAbJurkat 118016704 118017280 576 0
NRSF pAbJurkat 118017565 118018211 646 0
NRSF pAbJurkat 118019428 118019680 252 0
P300 T30-glioblastomaGSE21026 117983437 117985318 1881 0
RARA MCF7GSE15244 117996462 117996869 407 0
RARA MCF7GSE15244 117998490 117999770 1280 0
RARG MCF7GSE15244 117998864 117999725 861 0
Rb GrowingGSE19898 117986965 117987147 182 0
TFAP2C MCF7GSE21234 117983465 117984066 601 0
TFAP2C MCF7GSE21234 117998765 117999697 932 0
TFAP2C MCF7GSE21234 118017495 118017999 504 0
hScc1 BcellGSE12603 117984569 117987097 2528 0
hScc1 BcellGSE12603 118003705 118004087 382 0
hScc1 BcellGSE12603 118015779 118016145 366 0
hScc1 BcellGSE12603 118016593 118016863 270 0
hScc1 G2GSE9613 117983615 117984129 514 0
p130 SenescentGSE19898 117984442 117984897 455 0
p130 SenescentGSE19898 117985689 117985831 142 0
p130 shRbQuiescentGSE19898 117984507 117984908 401 0
p130 shRbSenescentGSE19898 117984453 117984856 403 0
p63 keratinocytesGSE17611 117998627 117999937 1310 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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