AutismKB 2.0

Annotation Detail for PSME4


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Basic Information Top
Gene Symbol:PSME4 ( FLJ21864,KIAA0077,MGC138374,MGC142228,PA200 )
Gene Full Name: proteasome (prosome, macropain) activator subunit 4
Band: 2p16.2
Quick LinksEntrez ID:23198; OMIM: 607705; Uniprot ID:PSME4_HUMAN; ENSEMBL ID: ENSG00000068878; HGNC ID: 20635
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
1121Phosphoserine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
18MethylarginineHMM predict
24MethylarginineHMM predict
82Phosphotyrosine(INSR)HMM predict
91Phosphoserine(PKA)HMM predict
221Phosphoserine(MAPK)HMM predict
269SulfotyrosineHMM predict
373Phosphotyrosine(Syk)HMM predict
377Phosphoserine(PKC)HMM predict
377PhosphoserineHMM predict
521Phosphoserine(CK1)HMM predict
561Phosphoserine(CK2)HMM predict
592O-linkedHMM predict
611N-linkedHMM predict
732SulfotyrosineHMM predict
738Phosphoserine(ATM)HMM predict
857Phosphotyrosine(Jak)HMM predict
979Phosphotyrosine(SRC)HMM predict
1034N-linkedHMM predict
1062Phosphoserine(ATM)HMM predict
1121Phosphoserine(CDC2)HMM predict
1206Phosphoserine(PKG)HMM predict
1415N-linkedHMM predict
1521N-linkedHMM predict
1525O-linkedHMM predict
1527Phosphoserine(ATM)HMM predict
1590Phosphoserine(PKB)HMM predict
1590O-linkedHMM predict
1614Phosphoserine(CK2)HMM predict
1652Phosphoserine(CK1)HMM predict
1654Phosphoserine(PKB)HMM predict
1667Phosphothreonine(PKC)HMM predict
1746Phosphoserine(IKK)HMM predict
1775Phosphotyrosine(Jak)HMM predict
1775Phosphotyrosine(Syk)HMM predict
1825Phosphothreonine(CK2)HMM predict
1841TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_014614
  • Location:chr2 53945074-54051353
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 54050827 54051949 1122 35
FOXA1 MCF7GSE15244 54069778 54070582 804 18827
FoxA1 MCF7MACSdata 54070077 54070493 416 18932
H3K4me3 colorectalcancer 54052016 54052482 466 896
H3ac HepG2E 54051984 54052643 659 960
H3ac HepG2E 54053260 54053950 690 2252
KLF4 hESGSE17917 54051431 54051620 189 172
Oct4 hESGSE21916 54051657 54052097 440 524
PHF8 HeLaGSE20725 54050766 54052368 1602 214
PHF8 Hs68minusFBSGSE20725 54051528 54052445 917 633
PHF8 Hs68plusFBSGSE20725 54050541 54052440 1899 137
RARA MCF7GSE15244 54069705 54070582 877 18790
TAF k562GSE8489 54053260 54053682 422 2118
TFAP2C MCF7GSE21234 54070014 54070704 690 19006
hScc1 BcellGSE12603 54051027 54051984 957 152
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 54049914 54050925 1011 0
FoxA1 MCF7MACSdata 54050012 54050300 288 0
H3K4me2 HCT116GSE10453 54049045 54049514 469 0
H3K4me2 HCT116GSE10453 54050166 54050794 628 0
H3K4me3 colorectalcancer 54050059 54050704 645 0
H3ac HepG2E 54049045 54051249 2204 0
Oct1 HelaGSE14283 54047741 54047773 32 0
TAF k562GSE8489 54049045 54050955 1910 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018