AutismKB 2.0

Annotation Detail for FLT1


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Basic Information Top
Gene Symbol:FLT1 ( FLT,VEGFR1 )
Gene Full Name: fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
Band: 13q12.3
Quick LinksEntrez ID:2321; OMIM: 165070; Uniprot ID:VGFR1_HUMAN; ENSEMBL ID: ENSG00000102755; HGNC ID: 3763
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
100N-linked (GlcNAc...) (Potential).
164N-linked (GlcNAc...) (Potential).
196N-linked (GlcNAc...) (Potential).
251N-linked (GlcNAc...) (Potential).
323N-linked (GlcNAc...) (Potential).
402N-linked (GlcNAc...) (Potential).
417N-linked (GlcNAc...) (Potential).
474N-linked (GlcNAc...) (Potential).
547N-linked (GlcNAc...) (Potential).
597N-linked (GlcNAc...) (Potential).
620N-linked (GlcNAc...) (Potential).
625N-linked (GlcNAc...) (Potential).
666N-linked (GlcNAc...) (Potential).
1048Phosphotyrosine.
1053Phosphotyrosine; by autocatalysis (By
1169Phosphotyrosine; by autocatalysis (By
1213Phosphotyrosine; by autocatalysis.
1242Phosphotyrosine; by autocatalysis.
1327Phosphotyrosine; by autocatalysis.
1333Phosphotyrosine; by autocatalysis.
Location(AA) Modifications Resource
100N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
164N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
196N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
251N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
323N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
402N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
417N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
474N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
547N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
597N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
620N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
625N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
666N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
794PhosphotyrosinePhospho.ELM 6.0
1053Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1169Phosphotyrosine (by autocatalysis) (Bysimilarity).Swiss-Prot 53.0
1169PhosphotyrosinePhospho.ELM 6.0
1213Phosphotyrosine (FLT1)Phospho.ELM 6.0
1213Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1242Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1242Phosphotyrosine (FLT1)Phospho.ELM 6.0
1327Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1327Phosphotyrosine (FLT1)Phospho.ELM 6.0
1333Phosphotyrosine (by autocatalysis).Swiss-Prot 53.0
1333Phosphotyrosine (FLT1)Phospho.ELM 6.0
Location(AA) Modification Resource
35Phosphoserine(CK1)HMM predict
62Phosphoserine(IKK)HMM predict
75Phosphoserine(CK1)HMM predict
100N-linkedHMM predict
109Phosphotyrosine(Syk)HMM predict
125SulfotyrosineHMM predict
164N-linkedHMM predict
196N-linkedHMM predict
199Phosphotyrosine(SRC)HMM predict
216Phosphotyrosine(INSR)HMM predict
236Phosphothreonine(MAPK)HMM predict
251N-linkedHMM predict
256Phosphothreonine(MAPK)HMM predict
256Phosphothreonine(CDK)HMM predict
321Phosphoserine(IKK)HMM predict
402N-linkedHMM predict
417N-linkedHMM predict
431Phosphotyrosine(EGFR)HMM predict
474N-linkedHMM predict
533Phosphotyrosine(INSR)HMM predict
597N-linkedHMM predict
620N-linkedHMM predict
625N-linkedHMM predict
634Phosphotyrosine(INSR)HMM predict
666N-linkedHMM predict
678O-linkedHMM predict
745Phosphotyrosine(Syk)HMM predict
786Phosphoserine(PKA)HMM predict
786Phosphoserine(PKG)HMM predict
959Phosphoserine(IKK)HMM predict
959Phosphoserine(PKA)HMM predict
965Phosphoserine(IKK)HMM predict
976Phosphoserine(CK1)HMM predict
978Phosphoserine(CK1)HMM predict
978Phosphoserine(CK2)HMM predict
1048Phosphotyrosine(Syk)HMM predict
1048Phosphotyrosine(INSR)HMM predict
1098Phosphoserine(CDC2)HMM predict
1098Phosphoserine(ATM)HMM predict
1124Phosphotyrosine(SRC)HMM predict
1125Phosphoserine(CK1)HMM predict
1125Phosphoserine(CK2)HMM predict
1169Phosphotyrosine(INSR)HMM predict
1234N-linkedHMM predict
1242SulfotyrosineHMM predict
1263O-linkedHMM predict
1276Phosphothreonine(PKC)HMM predict
1282Phosphoserine(CK2)HMM predict
1308Phosphothreonine(PKC)HMM predict
1308Phosphothreonine(PKA)HMM predict
1309Phosphotyrosine(PKA)HMM predict
1321S-farnesylHMM predict
1325ProlineHMM predict
1333Phosphotyrosine(Abl)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002019
  • Location:chr13 27773790-27967231
  • strand:-
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 27972702 27973049 347 5644
CTCF G2GSE9613 27973837 27974178 341 6776
H3K27me3 colorectalcancer 27967988 27970214 2226 1870
TFAP2C MCF7GSE21234 27967125 27967644 519 153
hScc1 BcellGSE12603 27968342 27969033 691 1456
hScc1 G2GSE9613 27972633 27973049 416 5610
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 27796408 27796633 225 0
CTCF CD4SISSRdata 27796408 27796633 225 0
CTCF G2GSE9613 27788238 27788736 498 0
CTCF G2GSE9613 27796315 27796804 489 0
CTCF G2GSE9613 27965974 27967953 1979 0
ER Fulvestrant-MCF7GSE14664 27866400 27866434 34 0
ER MCF7GSE19013 27914993 27915593 600 0
FOXA1 MCF7GSE15244 27812928 27813459 531 0
FOXA1 MCF7GSE15244 27829288 27830147 859 0
Fos K562GSE19551 27948211 27948806 595 0
FoxA1 MCF7MACSdata 27829488 27829750 262 0
Gata1 K562GSE18868 27880619 27881215 596 0
Gata2 K562GSE18868 27880587 27881109 522 0
H3ac HepG2E 27929795 27930016 221 0
Jun K562GSE19551 27948220 27948719 499 0
Nanog hESGSE18292 27910683 27911465 782 0
Nanog hESGSE18292 27927743 27928198 455 0
Oct1 H2O2-HelaGSE14283 27866401 27866429 28 0
Oct1 H2O2-HelaGSE14283 27910124 27910169 45 0
Oct1 HelaGSE14283 27866278 27866307 29 0
Oct1 HelaGSE14283 27866399 27866433 34 0
Oct1 HelaGSE14283 27878799 27878830 31 0
Oct1 HelaGSE14283 27910125 27910169 44 0
Oct1 HelaGSE14283 27959176 27959247 71 0
RARG MCF7GSE15244 27813002 27813459 457 0
RARG MCF7GSE15244 27829332 27830147 815 0
RARG MCF7GSE15244 27915170 27915522 352 0
RARG MCF7GSE15244 27949440 27950012 572 0
Rb QuiescentGSE19898 27961594 27961872 278 0
Rb SenescentGSE19898 27966256 27966431 175 0
Rb shRbQuiescentGSE19898 27788309 27788454 145 0
Sox2 hESGSE18292 27780654 27780893 239 0
Sox2 hESGSE18292 27927857 27928204 347 0
hScc1 BcellGSE12603 27788383 27788736 353 0
hScc1 BcellGSE12603 27796315 27796924 609 0
hScc1 BcellGSE12603 27800442 27800587 145 0
hScc1 BcellGSE12603 27965974 27967917 1943 0
hScc1 CdLSGSE12603 27796209 27796877 668 0
hScc1 CdLSGSE12603 27873786 27874130 344 0
hScc1 CdLSGSE12603 27966791 27967362 571 0
hScc1 G2GSE9613 27788420 27788736 316 0
hScc1 G2GSE9613 27796278 27796877 599 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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