AutismKB 2.0

Annotation Detail for SYNE2


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Basic Information Top
Gene Symbol:SYNE2 ( DKFZp434H2235,DKFZp686E01115,DKFZp686H1931,EDMD5,FLJ11014,FLJ43727,FLJ45710,FLJ46790,KIAA1011,NUA,NUANCE,Nesprin-2,SYNE-2,TROPH )
Gene Full Name: spectrin repeat containing, nuclear envelope 2
Band: 14q23.2
Quick LinksEntrez ID:23224; OMIM: 608442; Uniprot ID:SYNE2_HUMAN; ENSEMBL ID: ENSG00000054654; HGNC ID: 17084
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
841Phosphoserine.
955N6-acetyllysine.
2655Phosphoserine.
4108Phosphoserine.
4110Phosphoserine.
4111Phosphotyrosine.
6361Phosphoserine.
Location(AA) Modifications Resource
2655Phosphoserine.Swiss-Prot 53.0
2655PhosphoserinePhospho.ELM 6.0
6361Phosphoserine.Swiss-Prot 53.0
6361PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
50Phosphoserine(PKB)HMM predict
148Phosphotyrosine(Syk)HMM predict
162Phosphoserine(CDK)HMM predict
166Phosphoserine(CDC2)HMM predict
166Phosphoserine(CDK)HMM predict
166Phosphoserine(ATM)HMM predict
202N-linkedHMM predict
322N-linkedHMM predict
411Phosphoserine(CK1)HMM predict
413Phosphoserine(ATM)HMM predict
417Phosphoserine(ATM)HMM predict
417Phosphoserine(IKK)HMM predict
486Phosphotyrosine(Jak)HMM predict
697Phosphothreonine(PKC)HMM predict
705Phosphoserine(IKK)HMM predict
797N-linkedHMM predict
800Phosphoserine(ATM)HMM predict
836N-linkedHMM predict
853Phosphoserine(ATM)HMM predict
906N-linkedHMM predict
934Phosphoserine(CK1)HMM predict
1008Phosphoserine(CK1)HMM predict
1008Phosphoserine(ATM)HMM predict
1011Phosphoserine(IKK)HMM predict
1121Phosphothreonine(PKC)HMM predict
1142Phosphoserine(CK1)HMM predict
1142Phosphoserine(CK2)HMM predict
1143PhosphoserineHMM predict
1149Phosphoserine(CK1)HMM predict
1149Phosphoserine(CK2)HMM predict
1149Phosphoserine(IKK)HMM predict
1164N-linkedHMM predict
1198Phosphothreonine(PKC)HMM predict
1216Phosphoserine(PKG)HMM predict
1338Phosphoserine(PKG)HMM predict
1350PhosphothreonineHMM predict
1389MethyllysineHMM predict
1416Phosphotyrosine(INSR)HMM predict
1423Phosphothreonine(CK2)HMM predict
1469Phosphoserine(PKG)HMM predict
1637SulfotyrosineHMM predict
1638Phosphotyrosine(Syk)HMM predict
1693Phosphothreonine(PKC)HMM predict
1818Phosphotyrosine(Syk)HMM predict
1867Phosphothreonine(PKC)HMM predict
1889Phosphoserine(PKG)HMM predict
1941Phosphoserine(CK1)HMM predict
2006Phosphothreonine(CK2)HMM predict
2024Phosphothreonine(PKC)HMM predict
2030Phosphoserine(CAMK2)HMM predict
2030Phosphoserine(CK2)HMM predict
2106Phosphoserine(CK2)HMM predict
2215N-linkedHMM predict
2217Phosphoserine(PKA)HMM predict
2217Phosphoserine(PKC)HMM predict
2219PhosphoserineHMM predict
2254Phosphotyrosine(Jak)HMM predict
2262N-linkedHMM predict
2267N-linkedHMM predict
2319N-linkedHMM predict
2367Phosphothreonine(PKC)HMM predict
2430Phosphothreonine(CK2)HMM predict
2482N-linkedHMM predict
2484PhosphothreonineHMM predict
2583N-linkedHMM predict
2586N-linkedHMM predict
2700MethyllysineHMM predict
2781Phosphoserine(CAMK2)HMM predict
2781Phosphoserine(IKK)HMM predict
2805N-linkedHMM predict
2806N-linkedHMM predict
2826Phosphoserine(PKA)HMM predict
2866Phosphothreonine(CK2)HMM predict
2880Phosphoserine(ATM)HMM predict
2961Phosphoserine(CK1)HMM predict
2994S-palmitoylHMM predict
3040Phosphothreonine(CK2)HMM predict
3066Phosphothreonine(PKA)HMM predict
3075Phosphoserine(CK2)HMM predict
3075Phosphoserine(IKK)HMM predict
3088Phosphoserine(ATM)HMM predict
3108N-linkedHMM predict
3219N-linkedHMM predict
3220Phosphoserine(CK1)HMM predict
3221Phosphoserine(CK2)HMM predict
3255Phosphotyrosine(Syk)HMM predict
3257N-linkedHMM predict
3274Phosphoserine(CK1)HMM predict
3322Phosphoserine(ATM)HMM predict
3372Phosphotyrosine(EGFR)HMM predict
3372Phosphotyrosine(INSR)HMM predict
3372Phosphotyrosine(Jak)HMM predict
3372Phosphotyrosine(Syk)HMM predict
3372SulfotyrosineHMM predict
3374N-linkedHMM predict
3412Phosphoserine(CK2)HMM predict
3503Phosphothreonine(CK2)HMM predict
3659Phosphoserine(ATM)HMM predict
3683Phosphoserine(CDC2)HMM predict
3766Phosphotyrosine(Syk)HMM predict
3922Phosphoserine(ATM)HMM predict
3982N-linkedHMM predict
3988N-linkedHMM predict
4123Phosphoserine(CK1)HMM predict
4139Phosphoserine(IKK)HMM predict
4156Phosphoserine(CK1)HMM predict
4156Phosphoserine(CK2)HMM predict
4157Phosphoserine(CK1)HMM predict
4157Phosphoserine(CDC2)HMM predict
4159Phosphoserine(CK1)HMM predict
4161O-linkedHMM predict
4199N-linkedHMM predict
4217Phosphoserine(ATM)HMM predict
4338Phosphoserine(CK1)HMM predict
4350Phosphoserine(CK2)HMM predict
4418N-linkedHMM predict
4427O-linkedHMM predict
4427Phosphoserine(CK2)HMM predict
4427Phosphoserine(IKK)HMM predict
4432Phosphoserine(CK2)HMM predict
4432Phosphoserine(CDC2)HMM predict
4440Phosphoserine(IKK)HMM predict
4443Phosphoserine(CDC2)HMM predict
4443Phosphoserine(MAPK)HMM predict
4443Phosphoserine(CDK)HMM predict
4494Phosphothreonine(PKC)HMM predict
4513Phosphoserine(IKK)HMM predict
4520N-linkedHMM predict
4526Phosphotyrosine(INSR)HMM predict
4526SulfotyrosineHMM predict
4541Phosphoserine(IKK)HMM predict
4579Phosphotyrosine(Jak)HMM predict
4635N-linkedHMM predict
4640N-linkedHMM predict
4738Phosphoserine(ATM)HMM predict
4847Phosphotyrosine(EGFR)HMM predict
4847Phosphotyrosine(INSR)HMM predict
4978Phosphoserine(ATM)HMM predict
5003Phosphoserine(CK1)HMM predict
5079Phosphothreonine(CK2)HMM predict
5080Phosphoserine(CK1)HMM predict
5080Phosphoserine(CK2)HMM predict
5084Phosphoserine(CK1)HMM predict
5084Phosphoserine(IKK)HMM predict
5087Phosphoserine(CDC2)HMM predict
5087Phosphoserine(MAPK)HMM predict
5087Phosphoserine(CDK)HMM predict
5090O-linkedHMM predict
5135Phosphotyrosine(EGFR)HMM predict
5195Phosphothreonine(PKC)HMM predict
5233Phosphotyrosine(Jak)HMM predict
5260Phosphoserine(CK1)HMM predict
5286Phosphotyrosine(Syk)HMM predict
5329Phosphoserine(CK1)HMM predict
5329Phosphoserine(CK2)HMM predict
5330Phosphoserine(CK1)HMM predict
5367Phosphothreonine(PKA)HMM predict
5449N-linkedHMM predict
5601S-palmitoylHMM predict
5602S-palmitoylHMM predict
5642Phosphoserine(IKK)HMM predict
5644N-linkedHMM predict
5733Phosphoserine(CK1)HMM predict
5756Phosphothreonine(PKA)HMM predict
5757Phosphothreonine(PKA)HMM predict
5785Phosphoserine(PKG)HMM predict
5785Phosphoserine(CAMK2)HMM predict
5785Phosphoserine(ATM)HMM predict
5807Phosphoserine(IKK)HMM predict
5985N-linkedHMM predict
6046Phosphoserine(CK1)HMM predict
6099N-linkedHMM predict
6109Phosphothreonine(PKC)HMM predict
6145Phosphotyrosine(EGFR)HMM predict
6146Phosphoserine(CK2)HMM predict
6163N-linkedHMM predict
6207N-linkedHMM predict
6234Phosphothreonine(PKA)HMM predict
6277Phosphoserine(CK2)HMM predict
6348Phosphothreonine(PKA)HMM predict
6349Phosphoserine(PKB)HMM predict
6361Phosphoserine(CK2)HMM predict
6363N-linkedHMM predict
6384Phosphoserine(CK2)HMM predict
6388O-linkedHMM predict
6388Phosphoserine(CK1)HMM predict
6389Phosphoserine(CDC2)HMM predict
6389Phosphoserine(MAPK)HMM predict
6389Phosphoserine(ATM)HMM predict
6392Phosphoserine(IKK)HMM predict
6411Phosphoserine(CK2)HMM predict
6430Phosphoserine(CK2)HMM predict
6449Phosphoserine(ATM)HMM predict
6461Phosphoserine(IKK)HMM predict
6467Phosphotyrosine(SRC)HMM predict
6467Phosphotyrosine(Syk)HMM predict
6483O-linkedHMM predict
6484O-linkedHMM predict
6485O-linkedHMM predict
6485Phosphothreonine(CDC2)HMM predict
6485Phosphothreonine(CDK)HMM predict
6487Phosphotyrosine(INSR)HMM predict
6487Phosphotyrosine(SRC)HMM predict
6487Phosphotyrosine(Jak)HMM predict
6487Phosphotyrosine(Syk)HMM predict
6625Phosphoserine(IKK)HMM predict
6761Phosphoserine(IKK)HMM predict
6775Phosphoserine(CDC2)HMM predict
6775Phosphoserine(MAPK)HMM predict
6792O-linkedHMM predict
6851S-palmitoylHMM predict
6856Phosphoserine(CK2)HMM predict
6860Phosphotyrosine(INSR)HMM predict
6860Phosphotyrosine(Jak)HMM predict
6878TyrosineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015180
  • Location:chr14 63389453-63762902
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 63377576 63377744 168 11794
CTCF CD4SISSRdata 63377576 63377744 168 11794
PHF8 293TGSE20725 63389040 63389735 695 66
hScc1 BcellGSE12603 63388977 63389924 947 3
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
ER E2-MCF7GSE14664 63409150 63409186 36 0
ER E2-MCF7GSE14664 63486632 63486720 88 0
ER E2-MCF7GSE14664 63492943 63492980 37 0
ER E2-MCF7GSE14664 63587327 63587442 115 0
ER Fulvestrant-MCF7GSE14664 63486637 63486686 49 0
FOXA1 MCF7GSE15244 63459494 63460031 537 0
FoxA1 MCF7MACSdata 63400811 63401093 282 0
FoxA1 MCF7MACSdata 63459582 63459967 385 0
NRSF JurkatSISSRdata 63575773 63575937 164 0
Nanog ESGSE20650 63500586 63500968 382 0
Nanog hESGSE18292 63427443 63428232 789 0
Oct1 H2O2-HelaGSE14283 63409151 63409209 58 0
Oct1 H2O2-HelaGSE14283 63415905 63415942 37 0
Oct1 H2O2-HelaGSE14283 63542632 63542662 30 0
Oct1 H2O2-HelaGSE14283 63599737 63599764 27 0
Oct1 H2O2-HelaGSE14283 63600882 63600908 26 0
Oct1 HelaGSE14283 63415879 63415938 59 0
Oct1 HelaGSE14283 63425906 63425936 30 0
Oct1 HelaGSE14283 63428701 63428728 27 0
Oct1 HelaGSE14283 63435137 63435183 46 0
Oct1 HelaGSE14283 63466538 63466576 38 0
Oct1 HelaGSE14283 63598317 63598343 26 0
Oct4 hESGSE21916 63487565 63487783 218 0
P300 T30-glioblastomaGSE21026 63400653 63401421 768 0
P300 T30-glioblastomaGSE21026 63611444 63611811 367 0
RARA MCF7GSE15244 63401644 63401934 290 0
RARG MCF7GSE15244 63401365 63401934 569 0
RARG MCF7GSE15244 63406218 63406979 761 0
RARG MCF7GSE15244 63611662 63611844 182 0
RNAII Tamoxifen-MCF7GSE14664 63435140 63435187 47 0
Rb QuiescentGSE19898 63390004 63390124 120 0
STAT1 HeLaGSE12782 63400071 63401553 1482 0
STAT1 HeLaGSE12782 63432382 63433680 1298 0
STAT1 HeLaGSE12783 63400147 63401519 1372 0
STAT1 HeLaGSE12783 63432457 63433580 1123 0
STAT1 IFNSISSRdata 63400305 63401386 1081 0
Stat6 IL-4-hr4GSE17850 63546525 63547048 523 0
TFAP2C MCF7GSE21234 63459555 63460152 597 0
TFAP2C MCF7GSE21234 63597074 63597630 556 0
hScc1 BcellGSE12603 63406561 63406933 372 0
hScc1 CdLSGSE12603 63389161 63390655 1494 0
hScc1 CdLSGSE12603 63401033 63401900 867 0
p130 QuiescentGSE19898 63389987 63390134 147 0
p130 SenescentGSE19898 63389954 63390146 192 0
p130 shRbSenescentGSE19898 63389815 63390153 338 0
p63 keratinocytesGSE17611 63390093 63391093 1000 0
p63 keratinocytesGSE17611 63400590 63401386 796 0
p63 keratinocytesGSE17611 63459353 63460100 747 0
p63 keratinocytesGSE17611 63596337 63597607 1270 0
Validated miRNA targets Top
Micro RNA Name Stem Loop Name The chromosome that miRNA located Publication
hsa-let-7b hsa-let-7b 22 18668040
hsa-let-7b* hsa-let-7b 22 18668040
hsa-miR-1 hsa-mir-1-2 18 18668040
hsa-miR-1 hsa-mir-1-1 20 18668040
hsa-miR-155 hsa-mir-155 21 18668040
hsa-miR-155* hsa-mir-155 21 18668040
hsa-miR-16 hsa-mir-16-1 13 18668040
hsa-miR-16 hsa-mir-16-2 3 18668040
hsa-miR-30a hsa-mir-30a 6 18668040
hsa-miR-30a* hsa-mir-30a 6 18668040
hsa-miR-30b hsa-mir-30b 8 18668040
hsa-miR-30b* hsa-mir-30b 8 18668040
hsa-miR-30c hsa-mir-30c-2 6 18668040
hsa-miR-30c hsa-mir-30c-1 1 18668040
hsa-miR-30c-1* hsa-mir-30c-1 1 18668040
hsa-miR-30c-2* hsa-mir-30c-2 6 18668040
hsa-miR-30d hsa-mir-30d 8 18668040
hsa-miR-30d* hsa-mir-30d 8 18668040
hsa-miR-30e hsa-mir-30e 1 18668040
hsa-miR-30e* hsa-mir-30e 1 18668040
ID in Tarbase Data Type Support Type miRNA Gene Direct Support Publication
1008 Unknown pSILAC miR-155 SYNE2 down 50-25% 18668040
Ensembl Protein Type Differentially expressed in Pathology or Event Mis Regulation Gene Expression Tumour Involvement
ENSG00000054654 n_a n_a n_a "epithelium, lymphocyte, muscle cell, squamous cell" "malignant tumour, carcinoma, leukaemia, sarcoma"
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
8018 mRNA SYNE2 chr14 63389453 63762903 142201 mRNA ESR2 chr14 63620702 63830881 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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