AutismKB 2.0

Annotation Detail for PLCB1


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Basic Information Top
Gene Symbol:PLCB1 ( FLJ45792,PI-PLC,PLC-154,PLC-I,PLC154 )
Gene Full Name: phospholipase C, beta 1 (phosphoinositide-specific)
Band: 20p12.3
Quick LinksEntrez ID:23236; OMIM: 607120; Uniprot ID:PLCB1_HUMAN; ENSEMBL ID: ENSG00000182621; HGNC ID: 15917
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
333Phosphothreonine (By similarity).
334Phosphotyrosine (By similarity).
336Phosphothreonine (By similarity).
569Phosphoserine.
573Phosphothreonine.
887Phosphoserine; by PKC (By similarity).
972N6-acetyllysine.
976N6-acetyllysine.
Location(AA) Modifications Resource
333Phosphothreonine (By similarity).Swiss-Prot 53.0
334Phosphotyrosine (By similarity).Swiss-Prot 53.0
336Phosphothreonine (By similarity).Swiss-Prot 53.0
887Phosphoserine (by PKC) (By similarity).Swiss-Prot 53.0
887Phosphoserine (PKC
972N6-acetyllysine.Swiss-Prot 53.0
976N6-acetyllysine.Swiss-Prot 53.0
982Phosphoserine (MAP2K1)Phospho.ELM 6.0
Location(AA) Modification Resource
199N-linkedHMM predict
201Phosphoserine(CK1)HMM predict
239Phosphotyrosine(Jak)HMM predict
239Phosphotyrosine(Syk)HMM predict
308Phosphoserine(CDC2)HMM predict
328N-linkedHMM predict
332N-linkedHMM predict
334Phosphotyrosine(Syk)HMM predict
403Phosphoserine(CDC2)HMM predict
483Phosphoserine(PKA)HMM predict
483Phosphoserine(CK2)HMM predict
491Phosphoserine(CK1)HMM predict
501Phosphoserine(ATM)HMM predict
501O-linkedHMM predict
501Phosphoserine(MAPK)HMM predict
501Phosphoserine(CDC2)HMM predict
509Phosphothreonine(CK2)HMM predict
511Phosphoserine(CK2)HMM predict
511PhosphoserineHMM predict
582Phosphoserine(CDC2)HMM predict
589Phosphotyrosine(INSR)HMM predict
589Phosphotyrosine(Syk)HMM predict
609Phosphotyrosine(Syk)HMM predict
609Phosphotyrosine(INSR)HMM predict
803Phosphotyrosine(EGFR)HMM predict
847Phosphothreonine(MAPK)HMM predict
847Phosphothreonine(CDK)HMM predict
849O-linkedHMM predict
853O-linkedHMM predict
853O-linkedHMM predict
865N-linkedHMM predict
871O-linkedHMM predict
881Phosphoserine(ATM)HMM predict
887Phosphoserine(IKK)HMM predict
887Phosphoserine(PKC)HMM predict
894Phosphothreonine(CK2)HMM predict
909Phosphothreonine(PKC)HMM predict
978Phosphoserine(IKK)HMM predict
981Phosphoserine(CK1)HMM predict
982Phosphoserine(ATM)HMM predict
982Phosphoserine(CDC2)HMM predict
982Phosphoserine(CDK)HMM predict
1024Phosphotyrosine(Syk)HMM predict
1025Phosphotyrosine(EGFR)HMM predict
1025SulfotyrosineHMM predict
1029Phosphotyrosine(Syk)HMM predict
1089Phosphoserine(CK2)HMM predict
1150Phosphotyrosine(EGFR)HMM predict
1150Phosphotyrosine(Syk)HMM predict
1185Phosphoserine(IKK)HMM predict
1197Phosphothreonine(CDK)HMM predict
1197Phosphothreonine(MAPK)HMM predict
1199Phosphoserine(CK1)HMM predict
1199PhosphoserineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_182734
  • Location:chr20 8061295-8813544
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 8060596 8060955 359 520
CTCF CD4SISSRdata 8060596 8060955 359 520
FoxA1 MCF7MACSdata 8054918 8055119 201 6277
USF1 HepG2E 8057585 8059050 1465 2978
hScc1 BcellGSE12603 8060367 8061187 820 519
hScc1 CdLSGSE12603 8060161 8061425 1264 503
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 8234151 8234414 263 0
CTCF CD4GSE12889 8688393 8688519 126 0
CTCF CD4GSE12889 8782428 8782680 252 0
CTCF CD4SISSRdata 8234151 8234414 263 0
CTCF CD4SISSRdata 8688393 8688519 126 0
CTCF CD4SISSRdata 8782428 8782680 252 0
CTCF HelaGSE12889 8719100 8719388 288 0
CTCF G2GSE9613 8650958 8651372 414 0
CTCF G2GSE9613 8782423 8782853 430 0
ER MCF7GSE19013 8070646 8071185 539 0
ER MCF7GSE19013 8289665 8290359 694 0
FOXA1 MCF7GSE15244 8154167 8155090 923 0
FOXA1 MCF7GSE15244 8179038 8179565 527 0
FOXA1 MCF7GSE15244 8343630 8344046 416 0
FOXA1 eGFPGSE10845 8085251 8085633 382 0
FOXA1 eGFPGSE10845 8154167 8155090 923 0
FOXA1 eGFPGSE10845 8178325 8179565 1240 0
FOXA1 eGFPGSE10845 8343630 8344046 416 0
Fos K562GSE19551 8685169 8685521 352 0
FoxA1 MCF7MACSdata 8159742 8159974 232 0
FoxA1 MCF7MACSdata 8179282 8179535 253 0
FoxA1 MCF7MACSdata 8485199 8485356 157 0
H3ac HepG2E 8061468 8063016 1548 0
Nanog hESGSE18292 8318206 8318412 206 0
Nanog hESGSE18292 8688410 8688554 144 0
Nanog hESGSE18292 8782412 8782712 300 0
Oct4 hESGSE17917 8791670 8791886 216 0
P300 T30-glioblastomaGSE21026 8788382 8789557 1175 0
Pol3 GM12878GSE19551 8686579 8686883 304 0
RARA MCF7GSE15244 8178289 8179565 1276 0
RARA MCF7GSE15244 8343630 8344046 416 0
Rb GrowingGSE19898 8267363 8267494 131 0
STAT1 HeLaGSE12783 8343083 8343999 916 0
Sox2 hESGSE18292 8318155 8318467 312 0
Stat6 IL-4-hr4GSE17850 8594738 8595279 541 0
TFAP2C MCF7GSE21234 8343305 8343977 672 0
USF2 HepG2E 8179074 8179565 491 0
USF2 HepG2E 8260367 8260797 430 0
hScc1 BcellGSE12603 8382877 8383544 667 0
hScc1 BcellGSE12603 8649677 8650017 340 0
hScc1 BcellGSE12603 8650885 8651426 541 0
hScc1 BcellGSE12603 8782351 8782958 607 0
hScc1 CdLSGSE12603 8382848 8383376 528 0
hScc1 CdLSGSE12603 8649604 8650233 629 0
hScc1 CdLSGSE12603 8650775 8651426 651 0
hScc1 CdLSGSE12603 8782316 8782888 572 0
hScc1 G2GSE9613 8649756 8650100 344 0
hScc1 G2GSE9613 8650810 8651426 616 0
hScc1 G2GSE9613 8782351 8782782 431 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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