AutismKB 2.0

Annotation Detail for LPHN2


View Evidences View Variants View Annotations
Basic Information Top
Gene Symbol:LPHN2 ( CIRL2,CL2,LEC1,LPHH1 )
Gene Full Name: latrophilin 2
Band: 1p31.1
Quick LinksEntrez ID:23266; OMIM: 607018; Uniprot ID:LPHN2_HUMAN; ENSEMBL ID: ENSG00000117114; HGNC ID:
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
99N-linked (GlcNAc...) (Potential).
331N-linked (GlcNAc...) (Potential).
520N-linked (GlcNAc...) (Potential).
629N-linked (GlcNAc...).
731N-linked (GlcNAc...) (Potential).
744N-linked (GlcNAc...) (Potential).
787N-linked (GlcNAc...) (Potential).
792N-linked (GlcNAc...) (Potential).
813N-linked (GlcNAc...) (Potential).
1381Phosphoserine (By similarity).
1387Phosphoserine (By similarity).
Location(AA) Modifications Resource
99N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
331N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
520N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
629N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
731N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
744N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
787N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
792N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
813N-linked (GlcNAc...) (Potential).Swiss-Prot 53.0
1381Phosphoserine (By similarity).Swiss-Prot 53.0
1387Phosphoserine (By similarity).Swiss-Prot 53.0
Location(AA) Modification Resource
94Phosphothreonine(PKC)HMM predict
99N-linkedHMM predict
150Phosphotyrosine(Syk)HMM predict
312Phosphoserine(PKG)HMM predict
331N-linkedHMM predict
333Phosphoserine(CK1)HMM predict
402O-linkedHMM predict
406O-linkedHMM predict
406O-linkedHMM predict
408O-linkedHMM predict
419O-linkedHMM predict
420O-linkedHMM predict
421O-linkedHMM predict
422Phosphoserine(IKK)HMM predict
425Phosphoserine(IKK)HMM predict
425Phosphoserine(ATM)HMM predict
425O-linkedHMM predict
437Phosphoserine(ATM)HMM predict
451O-linkedHMM predict
499Phosphothreonine(PKA)HMM predict
520N-linkedHMM predict
629N-linkedHMM predict
744N-linkedHMM predict
745Phosphoserine(PKG)HMM predict
750N-linkedHMM predict
783Phosphotyrosine(INSR)HMM predict
787N-linkedHMM predict
792N-linkedHMM predict
804Phosphothreonine(PKC)HMM predict
813N-linkedHMM predict
818Phosphothreonine(PKA)HMM predict
861S-palmitoylHMM predict
1116Phosphoserine(ATM)HMM predict
1116O-linkedHMM predict
1120O-linkedHMM predict
1121Phosphothreonine(PKC)HMM predict
1130O-linkedHMM predict
1141N-linkedHMM predict
1148PhosphoserineHMM predict
1148Phosphoserine(PKG)HMM predict
1148Phosphoserine(CAMK2)HMM predict
1158N-linkedHMM predict
1164N-linkedHMM predict
1207Phosphoserine(CDK)HMM predict
1207Phosphoserine(CDC2)HMM predict
1218Phosphothreonine(PKA)HMM predict
1219Phosphoserine(PKA)HMM predict
1231N-linkedHMM predict
1232N-linkedHMM predict
1241Phosphotyrosine(EGFR)HMM predict
1255N-linkedHMM predict
1295Phosphoserine(CK2)HMM predict
1296Phosphoserine(CK2)HMM predict
1307Phosphoserine(CK1)HMM predict
1311Phosphoserine(ATM)HMM predict
1372Phosphotyrosine(INSR)HMM predict
1381Phosphoserine(CDC2)HMM predict
1395PhosphoserineHMM predict
1400Phosphoserine(CK1)HMM predict
1406SulfotyrosineHMM predict
1407Phosphotyrosine(Syk)HMM predict
1433Phosphotyrosine(INSR)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_012302
  • Location:chr1 82038669-82230693
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Nanog ESGSE20650 82019005 82019471 466 19432
Nanog hESGSE18292 82018850 82019631 781 19429
Oct1 HelaGSE14283 82038544 82038576 32 110
No data
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 82040263 82040527 264 0
CTCF G2GSE9613 82041072 82041376 304 0
FOXA1 MCF7GSE15244 82150643 82151033 390 0
FoxA1 MCF7MACSdata 82150708 82150926 218 0
Oct1 H2O2-HelaGSE14283 82102062 82102095 33 0
Oct1 H2O2-HelaGSE14283 82208380 82208428 48 0
Oct1 HelaGSE14283 82102058 82102096 38 0
Oct1 HelaGSE14283 82143400 82143431 31 0
Oct1 HelaGSE14283 82155921 82155954 33 0
Oct1 HelaGSE14283 82175348 82175386 38 0
Oct1 HelaGSE14283 82208380 82208443 63 0
PHF8 293TGSE20725 82039473 82040100 627 0
SRF GMOGSE8489 82119752 82120038 286 0
TAF k562GSE8489 82155847 82156100 253 0
TFAP2C MCF7GSE21234 82047104 82047445 341 0
TFAP2C MCF7GSE21234 82066296 82066566 270 0
USF2 HepG2E 82081734 82081925 191 0
hScc1 BcellGSE12603 82039052 82039410 358 0
hScc1 BcellGSE12603 82039866 82040489 623 0
p63 keratinocytesGSE17611 82112506 82113268 762 0
Validated miRNA targets Top
Cis-Nats regulation Top
Cluster ID Plue Type Plus Gene Name Plus Chromosome Plus Start Plus End Overlap Length Minus Type Minus Gene Name Minus Chromosome Minus Star Minus End Type
1018 mRNA LPHN2 chr1 81483904 82170127 43823 EST chr1 81691585 81735408 Non-exonic Bidirectional (NOB) pairs

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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