AutismKB 2.0

Annotation Detail for NEDD4L


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Basic Information Top
Gene Symbol:NEDD4L ( FLJ33870,KIAA0439,NEDD4-2,RSP5,hNedd4-2 )
Gene Full Name: neural precursor cell expressed, developmentally down-regulated 4-like
Band: 18q21.31
Quick LinksEntrez ID:23327; OMIM: 606384; Uniprot ID:NED4L_HUMAN; ENSEMBL ID: ENSG00000049759; HGNC ID: 7728
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
2N-acetylalanine.
302Phosphothreonine (By similarity).
303Phosphoserine.
318Phosphothreonine.
342Phosphoserine.
367Phosphothreonine; by SGK (Probable).
446Phosphoserine.
448Phosphoserine; by PKA and SGK.
449Phosphoserine.
464Phosphoserine.
479Phosphoserine.
483Phosphoserine.
487Phosphoserine.
Location(AA) Modifications Resource
302Phosphothreonine (By similarity).Swiss-Prot 53.0
342Phosphoserine (by PKA) (Probable).Swiss-Prot 53.0
342Phosphoserine (SGK
367Phosphothreonine (by SGK) (Probable).Swiss-Prot 53.0
367Phosphothreonine (SGK
446Phosphoserine (By similarity).Swiss-Prot 53.0
448Phosphoserine (by PKA and SGK).Swiss-Prot 53.0
448Phosphoserine (SGK
449PhosphoserinePhospho.ELM 6.0
479PhosphoserinePhospho.ELM 6.0
479Phosphoserine.Swiss-Prot 53.0
483PhosphoserinePhospho.ELM 6.0
483Phosphoserine.Swiss-Prot 53.0
487Phosphoserine.Swiss-Prot 53.0
487PhosphoserinePhospho.ELM 6.0
Location(AA) Modification Resource
10Phosphotyrosine(SRC)HMM predict
44Phosphotyrosine(Jak)HMM predict
44Phosphotyrosine(Jak)HMM predict
83N-linkedHMM predict
86N-linkedHMM predict
164Phosphoserine(CK1)HMM predict
180N-linkedHMM predict
182Phosphoserine(CK1)HMM predict
184Phosphoserine(ATM)HMM predict
216N-linkedHMM predict
251Phosphoserine(PKA)HMM predict
256PhosphoserineHMM predict
264Phosphoserine(CK1)HMM predict
297Phosphoserine(CDC2)HMM predict
297Phosphoserine(MAPK)HMM predict
300Phosphoserine(IKK)HMM predict
300O-linkedHMM predict
300O-linkedHMM predict
308Phosphoserine(CK2)HMM predict
308Phosphoserine(CK1)HMM predict
340Phosphoserine(PKB)HMM predict
366Phosphoserine(PKG)HMM predict
377O-linkedHMM predict
380Phosphotyrosine(Jak)HMM predict
408N-linkedHMM predict
426Phosphoserine(IKK)HMM predict
428Phosphoserine(IKK)HMM predict
446Phosphoserine(IKK)HMM predict
448Phosphoserine(CK1)HMM predict
449Phosphoserine(CDC2)HMM predict
453O-linkedHMM predict
464Phosphoserine(CDC2)HMM predict
475Phosphoserine(IKK)HMM predict
479Phosphoserine(ATM)HMM predict
479Phosphoserine(CDC2)HMM predict
479Phosphoserine(CDK)HMM predict
483O-linkedHMM predict
485Phosphotyrosine(Abl)HMM predict
487Phosphoserine(CDC2)HMM predict
487Phosphoserine(CDK)HMM predict
495Phosphothreonine(PKA)HMM predict
495O-linkedHMM predict
497Phosphoserine(IKK)HMM predict
632Phosphotyrosine(EGFR)HMM predict
660Phosphotyrosine(INSR)HMM predict
680SulfotyrosineHMM predict
690N-linkedHMM predict
696N-linkedHMM predict
756Phosphotyrosine(Jak)HMM predict
757Phosphotyrosine(Syk)HMM predict
757Phosphotyrosine(Jak)HMM predict
793N-linkedHMM predict
807Phosphotyrosine(INSR)HMM predict
807Phosphotyrosine(EGFR)HMM predict
932Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015277
  • Location:chr18 53862777-54216368
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 53861723 53862062 339 885
CTCF CD4SISSRdata 53861723 53862062 339 885
CTCF G2GSE9613 53861687 53861982 295 943
CTCF G2GSE9613 53862223 53862757 534 288
H3K4me3 colorectalcancer 53861195 53861726 531 1317
H3ac HepG2E 53861082 53861838 756 1318
Rb SenescentGSE19898 53861634 53861991 357 965
hScc1 BcellGSE12603 53861580 53862676 1096 650
hScc1 CdLSGSE12603 53861471 53862757 1286 664
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 54218306 54218486 180 2028
CTCF CD4SISSRdata 54218306 54218486 180 2028
CTCF G2GSE9613 54218085 54218494 409 1921
ER MCF7GSE19013 54223620 54224129 509 7506
H3ac HepG2E 54217421 54217668 247 1176
H3ac HepG2E 54224144 54224703 559 8055
H3ac HepG2E 54227456 54228586 1130 11653
H3ac HepG2E 54229341 54229744 403 13174
H3ac HepG2E 54231300 54231945 645 15254
H3ac HepG2E 54234328 54235505 1177 18548
Oct4 hESGSE17917 54218157 54218480 323 1950
USF1 HepG2E 54225874 54226797 923 9967
USF2 HepG2E 54225874 54228682 2808 10910
USF2 HepG2E 54230886 54233335 2449 15742
USF2 HepG2E 54234550 54235178 628 18496
hScc1 BcellGSE12603 54218013 54218458 445 1867
hScc1 BcellGSE12603 54222523 54222846 323 6316
hScc1 BcellGSE12603 54231336 54231647 311 15123
hScc1 CdLSGSE12603 54218013 54218680 667 1978
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T30-glioblastomaGSE21026 54048653 54049661 1008 0
CTCF CD4GSE12889 53940144 53940434 290 0
CTCF CD4GSE12889 53953997 53954262 265 0
CTCF CD4GSE12889 53999049 53999402 353 0
CTCF CD4GSE12889 54140390 54140671 281 0
CTCF CD4SISSRdata 53940144 53940434 290 0
CTCF CD4SISSRdata 53953997 53954262 265 0
CTCF CD4SISSRdata 53999049 53999402 353 0
CTCF CD4SISSRdata 54140390 54140671 281 0
CTCF HelaGSE12889 53954075 53954427 352 0
CTCF JurkatGSE12889 53953996 53954259 263 0
CTCF G2GSE9613 53954062 53954474 412 0
CTCF G2GSE9613 54109271 54109441 170 0
CTCF G2GSE9613 54140762 54141413 651 0
ER Breast-CancerGSE22609 54133092 54133663 571 0
ER E2-MCF7GSE14664 53871576 53871648 72 0
ER E2-MCF7GSE14664 53872981 53873076 95 0
ER E2-MCF7GSE14664 53987667 53987699 32 0
ER E2-MCF7GSE14664 54087141 54087180 39 0
Fos K562GSE19551 53876830 53877400 570 0
Fos K562GSE19551 53882948 53883314 366 0
Fos K562GSE19551 53906224 53906700 476 0
Fos K562GSE19551 54020502 54020979 477 0
FoxA1 MCF7MACSdata 53864741 53865010 269 0
FoxA1 MCF7MACSdata 54088090 54088453 363 0
Gata2 K562GSE18868 53896975 53897624 649 0
H3ac HepG2E 53863247 53867885 4638 0
H3ac HepG2E 54041225 54042919 1694 0
KLF4 hESGSE17917 54073239 54073402 163 0
KLF4 hESGSE17917 54155228 54155387 159 0
KLF4 hESGSE17917 54165412 54165568 156 0
Myc K562GSE19551 53897049 53897584 535 0
Myc K562GSE19551 53936128 53936659 531 0
Myc K562GSE19551 54020608 54020947 339 0
Myc K562GSE19551 54050144 54050497 353 0
NFkBII GM12878GSE19485 53917892 53919219 1327 0
NFkBII GM12892GSE19485 53918230 53919281 1051 0
NFkBII GM18526GSE19485 53917934 53919253 1319 0
Nanog ESGSE20650 53888055 53888582 527 0
Nanog hESGSE18292 53888229 53888496 267 0
Nanog hESGSE18292 53911534 53912069 535 0
Nanog hESGSE18292 53954181 53954447 266 0
Nanog hESGSE18292 54134937 54135448 511 0
Oct1 H2O2-HelaGSE14283 53871574 53871601 27 0
Oct1 H2O2-HelaGSE14283 53919911 53919947 36 0
Oct1 H2O2-HelaGSE14283 53927234 53927262 28 0
Oct1 H2O2-HelaGSE14283 54015322 54015352 30 0
Oct1 HelaGSE14283 53919918 53919947 29 0
Oct1 HelaGSE14283 53927233 53927264 31 0
Oct1 HelaGSE14283 53982204 53982247 43 0
Oct1 HelaGSE14283 53993047 53993085 38 0
Oct1 HelaGSE14283 54008575 54008607 32 0
Oct1 HelaGSE14283 54019171 54019198 27 0
Oct1 HelaGSE14283 54066912 54066954 42 0
Oct1 HelaGSE14283 54087107 54087173 66 0
Oct1 HelaGSE14283 54087246 54087277 31 0
Oct1 HelaGSE14283 54110664 54110701 37 0
Oct1 HelaGSE14283 54173483 54173560 77 0
Oct4 hESGSE17917 54165409 54165757 348 0
Oct4 hESGSE21916 53911486 53912006 520 0
Oct4 hESGSE21916 54073151 54073613 462 0
P300 T0-glioblastomaGSE21026 53995264 53995811 547 0
P300 T30-glioblastomaGSE21026 54041607 54043049 1442 0
P300 T30-glioblastomaGSE21026 54048685 54049687 1002 0
PAX3-FKHR Rh4GSE19063 54108215 54109706 1491 0
RNAII Tamoxifen-MCF7GSE14664 54027585 54027629 44 0
Rb GrowingGSE19898 53954068 53954296 228 0
Rb shRbQuiescentGSE19898 53907845 53907996 151 0
STAT1 HeLaGSE12783 54004542 54005614 1072 0
STAT1 HeLaGSE12783 54041731 54043181 1450 0
STAT1 IFNSISSRdata 54004684 54005352 668 0
Sox2 hESGSE18292 53888230 53888492 262 0
Stat6 IL-4-hr4GSE17850 53885586 53886096 510 0
Stat6 IL-4-hr4GSE17850 54072967 54073518 551 0
TFAP2C MCF7GSE21234 53898672 53899273 601 0
TFAP2C MCF7GSE21234 53905977 53906530 553 0
TFAP2C MCF7GSE21234 54001528 54001894 366 0
TFAP2C MCF7GSE21234 54041883 54042260 377 0
TFAP2C MCF7GSE21234 54042290 54042700 410 0
TFAP2C MCF7GSE21234 54049044 54049447 403 0
TFAP2C MCF7GSE21234 54081180 54081628 448 0
USF1 HepG2E 53953306 53954404 1098 0
USF2 HepG2E 53947905 53949793 1888 0
VDR GM10861-stimGSE22484 54047914 54050850 2936 0
c MYCMCF7 53947832 53949943 2111 0
hScc1 BcellGSE12603 53870072 53870540 468 0
hScc1 BcellGSE12603 53940155 53940405 250 0
hScc1 BcellGSE12603 53953950 53954656 706 0
hScc1 BcellGSE12603 53987882 53989789 1907 0
hScc1 BcellGSE12603 53998479 53999186 707 0
hScc1 BcellGSE12603 54050091 54050460 369 0
hScc1 BcellGSE12603 54073473 54074629 1156 0
hScc1 BcellGSE12603 54109081 54109686 605 0
hScc1 BcellGSE12603 54140264 54141301 1037 0
hScc1 BcellGSE12603 54187990 54188355 365 0
hScc1 BcellGSE12603 54192975 54193630 655 0
hScc1 CdLSGSE12603 53939954 53940405 451 0
hScc1 CdLSGSE12603 53953914 53954474 560 0
hScc1 CdLSGSE12603 53998761 53999424 663 0
hScc1 CdLSGSE12603 54140193 54140684 491 0
p130 QuiescentGSE19898 53863131 53863301 170 0
p130 QuiescentGSE19898 53953473 53953718 245 0
p130 shRbSenescentGSE19898 54039647 54039877 230 0
p63 keratinocytesGSE17611 54095105 54095879 774 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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