AutismKB 2.0

Annotation Detail for AFF2


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Basic Information Top
Gene Symbol:AFF2 ( FMR2,FRAXE,MRX2,OX19 )
Gene Full Name: AF4/FMR2 family, member 2
Band: Xq28
Quick LinksEntrez ID:2334; OMIM: 300806; Uniprot ID:AFF2_HUMAN; ENSEMBL ID: ENSG00000155966; HGNC ID: 3776
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
517Phosphothreonine.
Location(AA) Modifications Resource
Location(AA) Modification Resource
18SulfotyrosineHMM predict
78Phosphotyrosine(INSR)HMM predict
87N-linkedHMM predict
90N-linkedHMM predict
92N-linkedHMM predict
133O-linkedHMM predict
145N-linkedHMM predict
155Phosphoserine(CK1)HMM predict
168O-linkedHMM predict
172O-linkedHMM predict
172Phosphoserine(ATM)HMM predict
189Phosphoserine(ATM)HMM predict
220Phosphoserine(IKK)HMM predict
223N-linkedHMM predict
224Phosphoserine(CK2)HMM predict
238Phosphoserine(CDK)HMM predict
238Phosphoserine(IKK)HMM predict
238PhosphoserineHMM predict
238Phosphoserine(CDC2)HMM predict
251Phosphoserine(CDC2)HMM predict
332Phosphoserine(CK2)HMM predict
367Phosphoserine(IKK)HMM predict
370O-linkedHMM predict
387Phosphoserine(CK1)HMM predict
397Phosphothreonine(MAPK)HMM predict
430Phosphoserine(CK2)HMM predict
431Phosphoserine(CK2)HMM predict
481O-linkedHMM predict
481O-linkedHMM predict
484Phosphoserine(IKK)HMM predict
493Phosphoserine(CK1)HMM predict
496Phosphoserine(ATM)HMM predict
498Phosphoserine(ATM)HMM predict
498Phosphoserine(CK1)HMM predict
502Phosphoserine(CK1)HMM predict
504O-linkedHMM predict
507O-linkedHMM predict
509Phosphoserine(IKK)HMM predict
517O-linkedHMM predict
517Phosphothreonine(MAPK)HMM predict
549N-linkedHMM predict
551Phosphothreonine(MAPK)HMM predict
557O-linkedHMM predict
575N-linkedHMM predict
601Phosphothreonine(PKC)HMM predict
616Phosphothreonine(PKC)HMM predict
622Phosphoserine(ATM)HMM predict
637N-linkedHMM predict
639Phosphoserine(CK2)HMM predict
649N-linkedHMM predict
654Phosphothreonine(CDK)HMM predict
654Phosphothreonine(CDC2)HMM predict
718Phosphoserine(CK2)HMM predict
718Phosphoserine(CK1)HMM predict
720Phosphoserine(IKK)HMM predict
722Phosphothreonine(CK2)HMM predict
765Phosphoserine(IKK)HMM predict
779Phosphoserine(CDC2)HMM predict
779O-linkedHMM predict
839Phosphothreonine(PKA)HMM predict
883S-palmitoylHMM predict
885Phosphoserine(CDC2)HMM predict
885O-linkedHMM predict
898N-linkedHMM predict
899N-linkedHMM predict
905N-linkedHMM predict
918Phosphoserine(MAPK)HMM predict
918PhosphoserineHMM predict
918Phosphoserine(CDC2)HMM predict
931Phosphoserine(PKB)HMM predict
975Phosphothreonine(CDC2)HMM predict
983O-linkedHMM predict
985O-linkedHMM predict
987O-linkedHMM predict
989O-linkedHMM predict
995O-linkedHMM predict
997O-linkedHMM predict
1003O-linkedHMM predict
1004O-linkedHMM predict
1005O-linkedHMM predict
1007O-linkedHMM predict
1009O-linkedHMM predict
1018O-linkedHMM predict
1020O-linkedHMM predict
1024O-linkedHMM predict
1024O-linkedHMM predict
1025O-linkedHMM predict
1027O-linkedHMM predict
1028O-linkedHMM predict
1054Phosphoserine(CK1)HMM predict
1074SulfotyrosineHMM predict
1075SulfotyrosineHMM predict
1145Phosphoserine(CDC2)HMM predict
1210Phosphothreonine(MAPK)HMM predict
1212Phosphoserine(CDC2)HMM predict
1248N-linkedHMM predict
1252N-linkedHMM predict
1305ArginineHMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_002025
  • Location:chrX 147389830-147889897
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
Oct1 HelaGSE14283 147373478 147373512 34 16336
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
FOXA1 MCF7GSE15244 147899320 147900016 696 9771
FoxA1 MCF7MACSdata 147899394 147899644 250 9622
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CBP T0-glioblastomaGSE21026 147874353 147874776 423 0
CTCF JurkatGSE12889 147738537 147738657 120 0
CTCF G2GSE9613 147389466 147390253 787 0
CTCF G2GSE9613 147695015 147695253 238 0
ER E2-MCF7GSE14664 147465066 147465100 34 0
ER E2-MCF7GSE14664 147474244 147474287 43 0
ER E2-MCF7GSE14664 147518557 147518593 36 0
ER E2-MCF7GSE14664 147560246 147560283 37 0
ER E2-MCF7GSE14664 147568875 147568911 36 0
ER E2-MCF7GSE14664 147595348 147595380 32 0
ER E2-MCF7GSE14664 147641294 147641333 39 0
ER Fulvestrant-MCF7GSE14664 147445781 147445828 47 0
ER Fulvestrant-MCF7GSE14664 147474245 147474285 40 0
ER Fulvestrant-MCF7GSE14664 147475799 147475836 37 0
ER Fulvestrant-MCF7GSE14664 147481659 147481694 35 0
ER Fulvestrant-MCF7GSE14664 147521214 147521259 45 0
ER Fulvestrant-MCF7GSE14664 147560248 147560281 33 0
ER Fulvestrant-MCF7GSE14664 147595898 147595937 39 0
ER Fulvestrant-MCF7GSE14664 147614599 147614637 38 0
ER Fulvestrant-MCF7GSE14664 147641296 147641333 37 0
FOXA1 MCF7GSE15244 147521664 147521924 260 0
FOXA1 MCF7GSE15244 147743365 147744034 669 0
FOXA1 MCF7GSE15244 147751609 147751916 307 0
Myc K562GSE19551 147508264 147508658 394 0
NRSF-mono JurkatQuESTdata 147713214 147713571 357 0
NRSF-poly JurkatQuESTdata 147713247 147713490 243 0
Nanog hESGSE18292 147695789 147696270 481 0
Oct1 H2O2-HelaGSE14283 147414563 147414591 28 0
Oct1 H2O2-HelaGSE14283 147429941 147429977 36 0
Oct1 H2O2-HelaGSE14283 147451283 147451326 43 0
Oct1 H2O2-HelaGSE14283 147560247 147560281 34 0
Oct1 H2O2-HelaGSE14283 147576637 147576670 33 0
Oct1 H2O2-HelaGSE14283 147595904 147595941 37 0
Oct1 H2O2-HelaGSE14283 147606107 147606139 32 0
Oct1 H2O2-HelaGSE14283 147628521 147628549 28 0
Oct1 H2O2-HelaGSE14283 147641251 147641321 70 0
Oct1 H2O2-HelaGSE14283 147658723 147658752 29 0
Oct1 H2O2-HelaGSE14283 147714190 147714246 56 0
Oct1 HelaGSE14283 147391012 147391077 65 0
Oct1 HelaGSE14283 147394059 147394093 34 0
Oct1 HelaGSE14283 147395219 147395270 51 0
Oct1 HelaGSE14283 147414529 147414599 70 0
Oct1 HelaGSE14283 147429937 147429990 53 0
Oct1 HelaGSE14283 147438523 147438647 124 0
Oct1 HelaGSE14283 147438935 147438971 36 0
Oct1 HelaGSE14283 147443308 147443344 36 0
Oct1 HelaGSE14283 147445784 147445818 34 0
Oct1 HelaGSE14283 147446512 147446549 37 0
Oct1 HelaGSE14283 147451283 147451327 44 0
Oct1 HelaGSE14283 147460326 147460384 58 0
Oct1 HelaGSE14283 147460422 147460454 32 0
Oct1 HelaGSE14283 147465068 147465104 36 0
Oct1 HelaGSE14283 147466630 147466718 88 0
Oct1 HelaGSE14283 147474249 147474282 33 0
Oct1 HelaGSE14283 147475802 147475830 28 0
Oct1 HelaGSE14283 147481653 147481693 40 0
Oct1 HelaGSE14283 147497230 147497294 64 0
Oct1 HelaGSE14283 147518556 147518593 37 0
Oct1 HelaGSE14283 147526138 147526173 35 0
Oct1 HelaGSE14283 147560233 147560281 48 0
Oct1 HelaGSE14283 147568879 147568919 40 0
Oct1 HelaGSE14283 147568967 147569004 37 0
Oct1 HelaGSE14283 147573033 147573065 32 0
Oct1 HelaGSE14283 147579863 147579902 39 0
Oct1 HelaGSE14283 147591224 147591262 38 0
Oct1 HelaGSE14283 147593907 147593951 44 0
Oct1 HelaGSE14283 147595899 147595940 41 0
Oct1 HelaGSE14283 147606106 147606141 35 0
Oct1 HelaGSE14283 147615093 147615123 30 0
Oct1 HelaGSE14283 147615210 147615249 39 0
Oct1 HelaGSE14283 147641254 147641327 73 0
Oct1 HelaGSE14283 147658081 147658122 41 0
Oct1 HelaGSE14283 147658689 147658790 101 0
Oct1 HelaGSE14283 147700478 147700509 31 0
Oct1 HelaGSE14283 147714191 147714246 55 0
Oct1 HelaGSE14283 147719882 147719920 38 0
Oct4 hESGSE17917 147738568 147738718 150 0
RARA MCF7GSE15244 147743111 147744068 957 0
RARG MCF7GSE15244 147441469 147441694 225 0
RARG MCF7GSE15244 147743111 147744068 957 0
RNAII Tamoxifen-MCF7GSE14664 147612181 147612268 87 0
Rb GrowingGSE19898 147849067 147849333 266 0
Stat6 IL-4-hr4GSE17850 147736284 147736801 517 0
TFAP2C MCF7GSE21234 147757009 147757575 566 0
hScc1 BcellGSE12603 147389526 147390301 775 0
hScc1 CdLSGSE12603 147774318 147774741 423 0
hScc1 G2GSE9613 147389564 147390253 689 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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