AutismKB 2.0

Annotation Detail for LARS2


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Basic Information Top
Gene Symbol:LARS2 ( KIAA0028,LEURS,MGC26121 )
Gene Full Name: leucyl-tRNA synthetase 2, mitochondrial
Band: 3p21.31
Quick LinksEntrez ID:23395; OMIM: 604544; Uniprot ID:SYLM_HUMAN; ENSEMBL ID: ENSG00000011376; HGNC ID: 17095
Relate to Another Database: SFARIGene; denovo-db
Post Translation Modification Top
Location(AA) Modification
102"HIGH" region.
236N6-acetyllysine.
643"KMSKS" region.
Location(AA) Modifications Resource
Location(AA) Modification Resource
148Phosphoserine(IKK)HMM predict
381Phosphoserine(CK1)HMM predict
384O-linkedHMM predict
409Phosphoserine(CK2)HMM predict
503N-linkedHMM predict
509S-palmitoylHMM predict
517Phosphothreonine(PKA)HMM predict
708Phosphoserine(PKG)HMM predict
711Phosphoserine(CDC2)HMM predict
764Phosphoserine(ATM)HMM predict
891Phosphoserine(CDC2)HMM predict
Validated transcription factor binding site by ChIP-Chip and ChIP-Seq
  • RefSeq ID: NM_015340
  • Location:chr3 45405078-45565331
  • strand:+
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45404845 45405150 305 81
Myc K562GSE19551 45404543 45405438 895 88
P300 T0-glioblastomaGSE21026 45404567 45405568 1001 11
PHF8 293TGSE20725 45404573 45405577 1004 4
TAFII hESGSE17917 45404742 45405249 507 83
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF G2GSE9613 45567962 45568369 407 2834
Fos K562GSE19551 45567842 45568804 962 2992
P300 T30-glioblastomaGSE21026 45567447 45568784 1337 2784
TFAP2C MCF7GSE21234 45567984 45568569 585 2945
TFAP2C MCF7GSE21234 45571601 45572204 603 6571
VDR GM10855-stimGSE22484 45569232 45571575 2343 5072
VDR GM10861-stimGSE22484 45569146 45571887 2741 5185
hScc1 BcellGSE12603 45568759 45568938 179 3517
hScc1 BcellGSE12603 45584547 45584699 152 19292
p130 shRbSenescentGSE19898 45584360 45584537 177 19117
Transcrip Factors Experimental Cell Database TF Binding Start TF Binding End TF Binding Length The Distance to Gene
CTCF CD4GSE12889 45527981 45528265 284 0
CTCF CD4SISSRdata 45527981 45528265 284 0
CTCF HelaGSE12889 45515996 45516288 292 0
CTCF G2GSE9613 45480687 45480944 257 0
CTCF G2GSE9613 45507905 45508224 319 0
CTCF G2GSE9613 45561203 45561474 271 0
CTCF G2GSE9613 45562753 45563889 1136 0
CTCF G2GSE9613 45564281 45564738 457 0
ER E2-MCF7GSE14664 45478055 45478134 79 0
ER Fulvestrant-MCF7GSE14664 45515859 45515990 131 0
FOXA1 MCF7GSE15244 45414467 45415526 1059 0
H3K4me2 HCT116GSE10453 45406064 45406360 296 0
H3ac HepG2E 45405030 45406360 1330 0
Oct1 H2O2-HelaGSE14283 45406077 45406107 30 0
Oct1 H2O2-HelaGSE14283 45420454 45420498 44 0
Oct1 H2O2-HelaGSE14283 45472212 45472243 31 0
Oct1 H2O2-HelaGSE14283 45490595 45490623 28 0
Oct1 HelaGSE14283 45420454 45420498 44 0
Oct1 HelaGSE14283 45461154 45461182 28 0
Oct1 HelaGSE14283 45472215 45472243 28 0
Oct4 hESGSE21916 45404815 45405428 613 0
P300 T30-glioblastomaGSE21026 45404540 45405629 1089 0
P300 T30-glioblastomaGSE21026 45495919 45496772 853 0
Rb GrowingGSE19898 45525598 45525737 139 0
Rb GrowingGSE19898 45526050 45526338 288 0
Rb SenescentGSE19898 45525541 45525875 334 0
Rb shRbSenescenceGSE19898 45525493 45525804 311 0
Sox2 hESGSE18292 45563159 45563399 240 0
TFAP2C MCF7GSE21234 45429085 45429587 502 0
TFAP2C MCF7GSE21234 45496806 45497064 258 0
hScc1 BcellGSE12603 45481992 45482126 134 0
hScc1 BcellGSE12603 45511118 45511256 138 0
hScc1 G2GSE9613 45516173 45516388 215 0
p130 QuiescentGSE19898 45525602 45525725 123 0
p130 SenescentGSE19898 45525540 45526505 965 0
p130 shRbSenescentGSE19898 45525280 45526094 814 0
p130 shRbSenescentGSE19898 45526156 45526467 311 0
Validated miRNA targets Top
Cis-Nats regulation Top

Simple Query:


  (e.g. CHD8)

Syndromic Genes

Non-syndromic Genes

AutismKB Statistics

  • Studies: 1,036
  • Genes: 1,379
  • CNVs/SVs: 5,420
  • SNVs/Indels: 11,669
  • de novo Mutations: 5,669
  • Mosaics: 789
  • Linkage Regions: 172
  • Paper Collected: 6/30/2018
  • Last Update: 8/26/2018


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